Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0019158 (hepatitis)
 30,205 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Clostridium septicum infection causing 5.0 to 5.2% mortality is reported for the first time in the literature from six-week-old growing geese in three flocks comprising 5,200, 5,500 and 5,900 geese, respectively. The affected birds exhibited weakness, uncoordinated movement, ataxia and, frequently, oblique position of the head and neck (torticollis) as well as signs indicative of dysequilibrium. The affected birds died within 18-24 h. Gross pathological examination revealed anaemia, hepatitis with map-like necroses of irregular outline (Fig. 1), acute enteritis, pulmonary oedema and cardiac dilatation. Light and electron-microscopic examination showed that the sinusoids of the liver were markedly dilated (Fig. 2) and filled with serous exudate and gas (Figs 2 and 3), and the hepatocytes surrounding them exhibited severe oedema (Fig. 4). Among the hepatocytes, ciliated bacteria 7-10 mu in length and 1-3 mu in width, bounded by a well-defined cell wall and often showing signs of spore formation were observed (Figs 5 and 6). By bacteriological examination the pathogen was isolated, its properties were studied, and the clinical entity of malignant oedema was experimentally reproduced by intramuscular injection of guinea-pigs and rabbits. The applied antibiotic (oxytetracycline) and furazolidone therapy proved effective.
 ...
PMID:Demonstration of Clostridium septicum infection in a goose flock. 147 92

Otitis interna was diagnosed in five 9-to-21-day-old turkey poults with clinical signs of paralysis, opisthotonus, torticollis, blindness, and increased mortality. Gross and microscopic lesions in the poults included omphalitis, typhlitis, hepatitis, meningoencephalitis, ophthalmitis, neuritis and ganglionitis of the vestibulocochlear nerve, and otitis interna. Salmonella enterica arizonae was isolated from the brains, eyes, intestines, yolk sacs, and livers of poults. Birds with otitis interna also had meningoencephalitis. It is most likely that the S. enterica arizonae infection spread from the brain to the internal ears through the vestibulocochlear nerve. This is the first documentation of otitis interna caused by bacteria in an avian species.
 ...
PMID:Otitis interna (labyrinthitis) associated with Salmonella enterica arizonae in turkey poults. 1661 98

The coexistence of autoimmune hepatitis and juvenile idiopathic arthritis is very rare. This is the case of an 18 month old female patient whose first sign of disease was torticollis due to an underlying atlanto-axial subluxation. Three months later, bilateral knee arthritis developed and she was diagnosed with Juvenile Idiopathic Arthritis. Throughout the disease a persistent elevation of liver enzymes was noted, combined with positive antinuclear antibodies and hypergammaglobulinemia, reaching the diagnosis of concomitant autoimmune hepatitis.
...
PMID:[Unusual presentation of juvenile idiopathic arthritis and autoimmune hepatitis]. 2506 96

SummaryThe present report describes an outbreak of Pullorum disease in a young layer parent stock in Austria. The flock, which comprised 14,220 Lohmann brown layer chickens, experienced high mortality from the first week of life reaching a total of 1,905 chickens in the fifth week, when the flock was depopulated. Clinical signs included uneven size of the chicks, pasty vents, apathy, diminished water and feed intake, with some birds presenting central nervous system signs such as tremors and torticollis. The post-mortem investigation of 43 birds, ages one to four weeks, revealed retained yolk sacs filled with caseous exudate, purulent airsacculitis, hepatitis with whitish pinpoint coalescing necrotic foci, splenitis with splenomegaly, hemorrhagic-mucoid enteritis in the small intestine, fibrinous typhlitis, nephromegaly and urate deposits in the ureters and cloaca. Inflammation and/or necrosis were identified in liver, spleen, kidney, small intestine and heart by histopathology. However, no histopathological lesions were observed in the brain. Salmonella spp. were isolated from heart, liver, spleen and brain in pure culture. Group specific serotyping determined the presence of group D, with serovar S. Gallinarum being confirmed based on the Kauffmann-White Scheme. A duplex PCR further identified S. Pullorum as the responsible agent for the outbreak. Subsequently, the grandparent flocks, from which the affected flock originated, were tested and found to be negative for S. Pullorum, with no other progenies from the same GPs developing disease. Although the source of the pathogen could not be identified, such findings highlight the importance of "old" pathogens such as S. Pullorum causing sudden high mortality in chicks, even in a highly controlled environment.
 ...
PMID:An outbreak of Pullorum disease in a young layer parent flock in Austria presented with central nervous system signs. 3327 57

SummaryThe present report describes outbreaks of Streptococcus gallolyticus subsp. pasteurianus in young geese flocks in Austria. The flocks, which comprised 160-1450 goslings of 2 to 3 weeks of age, experienced increased mortalities The clinical signs were characterized by severe central nervous symptoms, namely leg paddling and torticollis. The post-mortem investigation revealed hepatitis, splenitis and low amount of liquid fluid in the coelomic cavity. Livers were of fragile texture, with white necrotic areas. The latter was also found in spleens. No macroscopic lesions were seen in brains. Bacteriological investigation followed by bacterial identification by MALDI-TOF MS and phylogenetic analysis based on partial 16S rRNA region revealed the presence in heart, liver, spleen and brain of Streptococcus gallolyticus subsp. pasteurianus . Histological investigation revealed multifocal necrosis in liver and spleen samples together with infiltration of mononuclear cells and heterophilic granulocytes. Furthermore, in the lesions coccoid bacteria could be identified. No histopathological changes were observed in brain samples from goslings, except in one bird in which accumulation of coccoid bacteria in blood vessels of the brain samples was present.Antibiotic sensitivity tests revealed identical profiles for all strains. The strains were susceptible to penicillins, cephalosporins, chloramphenicol, imipenem and tylosin. However, resistance was found against quinolones, aminoglycosides, tetracycline and trimethoprim-sulfamethoxazole which are commonly used to treat infections with gram-positive bacteria.
 ...
PMID:Outbreaks of Streptococcus gallolyticus subsp. pasteurianus in goslings characterized by central nervous symptoms. 3328 29