Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0019158 (hepatitis)
 30,205 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Twenty-one of 30 patients with essential mixed cryoglobulinemia (EMC) had evidence of liver involvement. The liver disease was characterized by the absence of clinical symptoms, hepatosplenomegaly, mild elevation of enzymes, abnormal BSP retention and low albumin levels. Histology, available in 12 patients, showed either chronic persistent or chronic active hepatitis or liver cirrhosis; 44% of the patients had HBsAg or HBsAb in sera and/or cryoglobulins, confirming the high frequency of exposure to hepatitis B virus (HBV) infection in EMC. However, liver lesions were similar in all patients, regardless of HBV exposure. Since other factors usually associated with chronic liver diseases were absent or apparently irrelevant, it is temptative to speculate that a 'cryoglobulinemic hepatitis' may exist as a distinct syndrome. The characteristic complement profile of the patients with EMC (low CH50 and C4, normal C3PA), not related to albumin levels, can help to differentiate this disease from chronic liver disease without cryoglobulins.
 ...
PMID:Liver involvement in essential mixed cryoglobulinemia. 54 44

All previous experiences have shown that the application of blood, blood components and intravenous solutions presents an unreplaceable therapeutical measure in modern surgical-resuscitative management of war injuries. Together with the broad application of the whole blood, there have been also used other blood components (even such as cryoprecipitate and platelet rich plasma). Among intravenous solutions the most frequently mentioned were isotonic saline, Ringer's lactate solution, glucosaline, 5% dextrose solution, dextran solutions and, recently, human albumin solutions. Due to a high risk of transmission of hepatitis virus, the dried pooled human plasma is less frequently used. There is the generally accepted agreement that availability of the sufficient quantity of blood, blood components and intravenous solutions resulted in the decreased mortality of the wounded. The role of intravenous solutions is of particular importance in the initial phase of management of the wounded and in the situations when it is necessary to wait for blood.
 ...
PMID:[Transfusion-infusion therapy in modern wars]. 75 89

Amino acid imbalance ratio was determined in apparently healthy Pakistanis and patients with hepatitis and cirrhosis of the liver. The ratio was normal in 75% of the patients with actue viral hepatitis but in only 5% with cirrhosis of the liver. The ratio was abnormal in 25% cases of acute viral hepatitis possibly due to aminoaciduria. The abnormal ratio in cirrhosis of the liver indicated the functional capacity for albumin synthesis and correlated well with serum albumin concentration.
 ...
PMID:Aminoacid imbalance ratio in liver disease. 82 73

Amino acid imbalance ratio was determined in apparently healthy Pakistanis and patients with hepatitis and cirrhosis of the liver. The ratio was normal in 75% of the patients with acute viral hepatitis but in only 5% with cirrhosis of the liver. The ratio was abnormal in 25% cases of acute viral hepatitis possibly due to aminoaciduria. The abnormal ratio in cirrhosis of the liver indicated the functional capacity for albumin synthesis and correlated well with serum albumin concentration.
 ...
PMID:Aminoacid imbalance ratio in liver disease. 82 59

The turnover of 125I-labelled fibrinogen and 131I-labelled albumin was studied in the course of galactosamine-induced hepatitis in rabbits. In addition to galactosamine, some animals were treated with epsilon-aminocaproic acid (EACA) to inhibit the activation of the fibrinolytic system. The infusion of galactosamine and EACA caused generation of fibrin-rich microclots in the renal glomerular capillaries in seven out of 12 rabbits. Correspondingly, the incorporation of 125I-radioactivity into liver, spleen, and kidneys was pronounced in galactosamine- and EACA-treated rabbits compared with control animals treated with EACA. An acceleration of the 125I-fibrinogen elimination from the plasma was observed between eight and 12 hours after the start of the galactosamine infusion. The administration of heparin in addition to galactosamine and EACA prevented the occurrence of intravascular coagulation, but shortened the survival times of the animals because of bleeding into visceral organs. The elimination of 131I-albumin in plasma as well as the distribution of 131I-radioactivity in organs were similar in all the rabbits independent of the treatment with galactosamine, EACA, or heparin. The experiments indicate that, in addition to diminished synthesis of coagulation factors, disseminated intravascular coagulation is involved in galactosamine-induced hepatitis and contributes to the haemostatic disorder.
 ...
PMID:Behaviour of 125I-fibrinogen and 131I-albumin in experimental galactosamine-induced hepatitis. 87 36

40 patients with infectious hepatitis, 25 with chronic aggressive hepatitis, 25 with compensated liver cirrhosis, and 10 with decompensated liver cirrhosis were submitted to examination. The following abnormalities depending upon the stage and severity of hepatic diseases were found: a) disturbances of total lipids, cholesterol, phospholipids, beta-lipoproteids, glycerin, glycerides and neutral fats concentrations; b) marked disorders of glucose tolerance as indicated by the difference between plasma and erythrocyte glucose levels increasing in proportion to the degree of liver damage; c) a fall in plasma and erythrocyte magnesium reflecting the degree of hepatic parenchyma damage; d) a decrease of the albumin/gamma-globulin ratio in proportion to the degree of the impairment of hepatic cells. The presented fat, carbohydrate, magnesium and protein balance indices yield better criterions for the differential diagnostics of hepatic diseases than the routine investigations, and they also make possible objective prognosis.
 ...
PMID:Disturbances of fat, carbohydrate, magnesium and protein balance in liver diseases. 88 63

In 104 patients with acute virus hepatitis, chronic hepatitides, cirrhoses, fatty livers and biliary diseases with partial and complete obstructive jaundice, respectively, IgG, IgA, IgD, beta1A- and beta1E-globulin, cholinesterase, total protein, and albumin, in 45 of these patients additionally prealbumin, retinol binding protein, thymol turbidity test were determined as well as an electrophoretic separation of the serum was performed. 11 persons with healthy liver served as control group. According to the results of univariate and multivariate variance analyses with following test of redundance (test for indispensability) and analysis of discriminance with calculations of reclassification IgD, beta1E-globulin and retinol binding protein were identified as not evident or redundant. Electrophoresis and thymol turbidity test give sufficient basis informations and can further be recommended for orienting examinations. Immune globulinogrammes from IgB, IgA and IgM are suitable as so-called mesenchyma tests particularly for controls of the course. Prealbumin and cholinesterase prove to be the most sensitive parameter of synthesis, whereas albumin and beta1A-globulin possess a high prognostic evidence.
 ...
PMID:[Discriminatory function of serum proteins in liver and biliary tract diseases]. 91 May 27

Antibodies to hepatitis Bs antigen identified only by radioimmunoassay, which is 8000 times more sensitive than counterelectrophoresis, were found in blood donors in 17%, in the Haemodialysis centre in 44%, in the patients of this centre in 47%. HBsAg and the antibodies have been tested in different series of albumin and gammaglobulin. Immunoglobulin anti HBs was prepared by the Blood transfusion centre in Ljubljana, and the Imunoloski zavod in Zagreb, and the problem of prevention, and production is discussed. Antigen-antibody complexes were prepared in vitro, and the results of the respective tests described.
 ...
PMID:[Antibodies against HBs antigens as identified using the radioimmunologic method]. 92 32

Endogenous or deliberately added hepatitis B antigen was removed and concentrated for assay from albumin, and from coagulation factor II, VII, IX, and X concentrates as model plasma fractions. The concentrates carry considerable risk of causing hepatitis in transfused patients. The amount of antigen remaining in the fraction was estimated to be less than 1/10,000 of that detectable by the Ausria II radioimmunoassay and 1/100 of that found to be infectious when highly contaminated human sera were diluted and injected in chimpanzees. Batch fractionation methods with polyethylene glycol were used. The yield of albumin was 96 per cent and of the coagulation factors about 90 per cent.
 ...
PMID:Removal of hepatitis B surface antigen (HBsAg) from plasma fractions. 93 37

Serum proteins were estimated in two patient groups, namely (i) 20 cases with proven ameobic liver abscess and (ii) 12 cases with hepatic amoebiasis without demonstrable pus, commonly referred to by the misnomer 'ameobic hepatitis'. In amoebic liver abscess a fall in albumin and an increase in alpha 2 and gamma globulin results in a serum protein pattern somewhat different from that in hepatic amoebiasis without demonstrable pus, where an elevation in gamma globulin was infrequent. Post-therapy serum protein estimations revealed that, irrespective of the presence or absence of pus, a rising gamma globulin level in hepatic amoebiasis may be of prognostic significance and post-treatment surveillance would be necessary in patients showing this type of response.
 ...
PMID:Serum proteins in hepatic amoebiasis. 93 32


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>