Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0019158 (hepatitis)
 30,205 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A young women with clinical and histological features of chronic active hepatitis was noted to have extremely high levels of immunoglobulin (14.6 g per dl). This was associated with the hyperviscosity syndrome, diffuse coagulation abnormalities, and renal insufficiency in the absence of severe liver disease. Correction of these features occurred with plasmapheresis before corticosteroid therapy was begun. A similar group of persons with very high gamma-globulin levels, described previously under the heading of "plasma cell hepatitis," may form a distinct and rare subgroup of chronic active hepatitis patients.
 ...
PMID:Hyperviscosity syndrome attributable to hyperglobulinemia in chronic active hepatitis. 7 88

Increased incidence of renal insufficiency is observed in severe damage of liver parenchyma such as fulminant hepatitis, decompensated cirrhosis of the liver, septic cholangitis and the different forms of obstructive jaundice. Functional circulatory disturbances of the kidney, especially of the renal cortex, are of importance in the aetiology of this condition. Dopamine, at a dosage as low as 3 gamma/kg/min leads to an improvement in renal blood flow and also to an increase in hepatic blood flow. These observations are of therapeutic importance. Some important circulatory and functional parameters of both these organs, which influence each other under normal and pathological conditions, were studied in the presence of dopamine and the following results were obtained: 1. An investigation of the intrarenal haemodynamics with 133 Xenon in patients with severe cirrhosis of the liver and in patients with obstructive jaundice resulted in an increase of 91% in the mean renal blood flow. The blood flow in the renal cortex increased by 36.2% and in the renal medulla 18.5%, whereas the renal fat tissue showed no change. Compartment I, which was diminished as compared with the control value, also increased. The percentage contribution of the mean renal blood flow and the blood flow of the renal cortex towards the cardiac output was greater under the influence of dopamine; hence a greater part of the cardiac output flows into the kidney under dopamine. 2. The glomerular filtrate and the renal plasma flow increased under dopamine (13.5% and 43.1%, respectively). The increase was greater in compensated than in decompensated cirrhosis. In patients with obstructive jaundice there was a smaller increase in both these parameters than in patients with cirrhosis in the presence of dopamine. No connection was found between the increase in renal plasma flow with dopamine and the blood levels of bilirubin, cholinesterase, GOT and the Normotest. 3. The urinary output of sodium increased by 191.4% with dopamine. Patients with an initial renal plasma flow value of over 300 ml/min had a higher sodium output. These patients also eliminated more sodium under the influence of dopamine than those with an initial renal plasma flow value of under 300 ml/min. 4. Blood flow determinations in the portal vein and the hepatic artery in man, obtained during operation, showed an increase in portal flow of 28.5% and hepatic artery flow of 6.3% in response to dopamine. The percentage contribution of portal blood flow towards the cardiac output increase on dopamine administration. The functional hepatic blood flow, analyzed with 131-J-BSP, did not change. The wedged hepatic vein pressure, which is a good measure of portal pressure, increased on average by only 7% with dopamine at a dosage of 3 gamma/kg/min, but by 20.3% with twice the dosage. Dopamine did not cause a change in hepatic blood volume; hence, blood sequestration in the liver can be excluded in response to the dopamine-evoked increase in portal blood flow. 5...
 ...
PMID:[Clinical and experimental investigations of the effect of dopamine on haemodynamics and function of kidney and liver (author's transl)]. 27 63

The association in therapeutic doses of gentamicin and furosemide resulted, in a young patient suffering from post-B virus hepatitis cirrhosis, in renal insufficiency which was spontaneously regressive when the drugs were stopped. Gentamicin, used without furosemide, was not associated with any impairment of renal function. A review of the literature indicates a number of pathogenic hypotheses to explain the increased nephrotoxicity of this drug combination.
 ...
PMID:[Renal toxicity of the association: gentamicin/furosemide. One case (author's transl)]. 63 73

Tetracyclines are active in vitro against most urinary tract pathogens, Chlamydia, Mycoplasma pneumoniae, Brucella, rickettsiae, and Nocardia. Chloramphenicol is used primarily for anaerobic infections, Haemophilus influenzae meningitis, and infections due to Salmonella typhi. Erythromycin is active in vitro against M. pneumoniae, Streptococcus pneumoniae, and group A beta-hemolytic streptococci. Erythromycin may be used as prophylactic therapy for subacute bacterial endocarditis and for recurrence of acute rheumatic fever in patients who are allergic to penicillin. Clindamycin should be used only for the treatment of anaerobic infections. Tetracycline may cause gastrointestinal upset; phototoxic dermatitis; hepatitis, especially in pregnant females; discoloration of teeth and bone dysplasia in the human fetus and children; and suprainfections, especially oral and anogenital candidiasis. Tetracycline should be used with caution in patients with renal insufficiency. The most important toxic effect of chloramphenicol is bone marrow suppression, which is dose related and idiosyncratic. The incidence of undesirable side effects associated with the use of erythromycin is low. Gastrointestinal irritation is the most common; cholestatic hepatitis may occur with erythromycin estolate. Pseudomembranous colitis is the most important toxic effect associated with clindamycin.
 ...
PMID:Tetracyclines, chloramphenicol, erythromycin, and clindamycin. 90 15

The elimination of para-aminosalicylic acid (PAS) after the intravenous injection of 20 mg PAS sodium/kg was estimated in patients with liver disease, in uremic patients and in volunteers without damage of the liver or kidneys. The drug was estimated with a colorimetric and fluorometric method. In the volunteers, the half-lives obtained with the fluorometric method were significantly longer than those estimated with the colorimetric method. This is caused by the estimation of more PAS metabolites by the used fluorometric method. In the patients with renal insufficiency (dialysis patients) the elimination rate of unchanged PAS--estimated with the colorimetric method--was not altered, whereas the elimination of PAS and its metabolites extractable by ethyl acetate was markedly slowed in comparison with the results obtained with the volunteers. The clearance of the unchanged PAS was even increased in the uremic patients. The serum protein binding of PAS was lowered significantly in the serum of uremic patients. In patients with liver cirrhosis, acute virus hepatitis and cholangitis the elimination rate of the drug was not altered in comparison with the volunteers. The results show that the dose of PAS in patients with renal insufficiency may not be reduced. The therapeutic level of the drug cannot otherwise be reached in these patients.
 ...
PMID:Elimination of para-aminosalicylic acid in patients with liver disease and renal insufficiency. 92 30

A 38-year old woman receiving phenytoin (diphenylhydantoin) noticed maculopapular erythema as the first manifestation of a syndrome that included acute renal failure and myositis in addition to fever, lymphadenopathy, exfoliative dermatitis, and hepatitis. Prednisolone sodium phosphate therapy resulted in resolution of this hypersensitivity reaction, and she recovered from renal insufficiency. The occurrence of renal failure and myositis in the spectrum of phenytoin hypersensitivity reactions is discussed, and the importance of a morbilliform rash in a patient receiving phenytoin is emphasized.
 ...
PMID:Reversible renal failure and myositis caused by phenytoin hypersensitivity. 103 71

Notes on the literature data concerning renal alterations observed in the course of virus diseases, and on the results of experiments designed to show the nephrotoxic action of viruses and their possible investigation of certain nephropathies, are followed by the presentation of a case of serious renal insufficiency in a young woman with virus hepatitis. The clinical data, the history and the results of blood chemistry and function tests showed this to be attributable to glomerulonephritis, probably caused by the same virus.
 ...
PMID:[Case of severe renal insufficiency appearing during a course of viral hepatitis]. 120 46

In a centre for dialytic treatment of the district Karl-Marx-Stadt during 16 months patients and staff underwent a continuous clinico-epidemiological observation. By means of determinations of serum enzymes and Au-antigen-investigation regularly carried out in these cases the special risk of hepatitis could be confirmed. Hygienic-antiepidemic and organization measures are discussed and recommendations are given concerning the prophylactically more aimed course. Further investigations are necessary in as far as certain basic diseases (i.g., renal insufficiency) have an influence on the Au-antigen-persistence by impairment of the immune system and which epidemiological effects may result from this.
 ...
PMID:[Problems of hepatitis in dialysis patients, technical personnel and their relatives]. 122 32

The most important complications after open heart surgery are neurological, gastrointestinal (GI), and renal complications. New neurological deficits may occur in 1%, and neuropsychiatric alterations may be observed in 40%. In 6% peripheral neurological damage occurs. Endoscopy in all patients whose clinical history suggests signs of gastric ulcer disease, and perioperative H2-blocking therapy are effective in reducing severe GI bleeding to 1%. Small-bowel ischemia is a rare but high risk complication. Hepatitis due to homologous blood transfusion is as low as 2%-3%. Postoperative renal insufficiency occurs in 1% needing hemodialysis. Good hemodynamic condition during and after surgery reduces the frequency of extracardiac complications as well as the reduction of use of homologous blood transfusions for open heart surgery.
 ...
PMID:[Non-cardiac complications after open heart surgery]. 149 16

We describe a patient with rheumatoid arthritis (RA) who developed hypersensitivity after 3 weeks of therapy with azathioprine with fever, jaundice and renal insufficiency. A percutaneous liver biopsy was compatible with hypersensitivity hepatitis. During azathioprine rechallenge, the symptoms recurred within a few days, consistent with the diagnosis of an acute hypersensitivity reaction. This report is the first to describe the association of an azathioprine induced hypersensitivity simultaneously involving the liver and the kidneys, in the same patient with RA, with resurgence after rechallenge.
 ...
PMID:Fever, hepatitis and acute interstitial nephritis in a patient with rheumatoid arthritis. Concurrent manifestations of azathioprine hypersensitivity. 161 15


1 2 3 4 5 6 7 Next >>