Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0019158 (hepatitis)
 30,205 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The authors analyse the possibilities of ultrasonic diagnosis of the diffuse liver diseases. Sixty normal subjects and 114 patients (50 with chronic hepatitis, 30 with hepatosis, 34 liver cirrhosis) were examined. The authors suggest a new method consisting in the measurement of the "compensation power", i. e. of the energy that is consumed during penetration via hepatic tissues with more energy being consumed the denser the tissue. A significant difference in that parameter was recorded between hepatitis, liver cirrhosis and hepatosis, permitting the differentiation between the illnesses under consideration. Study of the other parameters (the length, width, liver log, the diameter of the vena cava inferior, of the splenic vein and spleen) enables expanding the number of indicators used in the diagnosis and differential diagnosis of the liver diseases.
 ...
PMID:[Ultrasonic diagnosis of liver diseases]. 638 4

A total of forty-four biopsies from nine liver transplantation patients, who had developed complications postoperatively, were studied histologically and, in part, electron-microscopically. Morphologic signs of acute rejection were seen in three patients, while there were indications of chronic rejection in one patient. In combined lesions, such as drug-induced hepatosis, cholangitis, hepatitis, and rejections, the interpretation of biopsy findings may be difficult, and special entities cannot in every case be separated unequivocally. Changes of serum bilirubin and of serum enzyme activity do not run entirely parallel to the microscopically detectable structural lesions. For diagnosis of complications after liver transplantation both the morphologic and the clinical findings must be considered.
 ...
PMID:[Value of histopathologic findings following liver transplantation based on biopsy course studies]. 639 61

Clinical differential diagnosis of neonatal icteric diseases not infrequently appears to be difficult. Diagnostic means are limited. The needle biopsy of the liver has become an important aid in the diagnosis of neonatal liver diseases. Authors have analysed 21 biopsies obtained from children with congenital bile duct atresia and 8 biopsies from children with cholestatic hepatosis. Findings are compared with those revealed in neonatal hepatitis and other processes. The early changes (intracanalicular and intraductal cholestasis) are similar both in congenital bile duct atresia and in cholestatic hepatosis. In the later phase of the process in cholestatic hepatosis and in other diseases increasing cholestasis and a secondary damage to the parenchyma, but first of all portal changes came into being and gave a reliable basis for the differential diagnosis. Liver biopsy is indispensable for the diagnosis of mentioned diseases.
 ...
PMID:[Role and significance of needle biopsy of the liver in the diagnosis of congenital bile duct atresia]. 726 45

Cholestasis is a combination of defined clinical, paraclinical and morphological findings of which icterus is the direct symptom. It is the consequence of the delay or detention of the bile flow. By means of light microscopy different changes can be observed in hepatic tissue: formation of biliary thrombi, intracellular deposition of biliary components, ductal cholestasis with dilatation of the bile-duct lumina and applanation of the bile-duct epithelium, ductular proliferates and furthermore inflammatory mesenchymal reactions with cholangiolitis and cholangitis. These changes strengthen in dependence on the intensity and duration of the existing cholestasis. Bile lakes, bile extravasates, and biliary infarctions may occur in the process. The differentiation between intrahepatic non-mechanically and (extra-)hepatic mechanically conditioned cholestasis is of clinical importance. In the former the production and secretion of bile is disturbed (hepatosis, hepatitis and others), in the latter the extrahepatic bile ducts are above all affected: the bile flow is disturbed by stenosis, compression and obturation. The differentiation between the two kinds of cholestasis is impossible in the first three weeks because both of them develop identical lesion patterns. Distinguishable changes occur only after that. Consequently, findings from liver biopsy can only be a statement of probability. Reliable differentiation between the two kinds of cholestasis is however possible by means of modern technical methods for diagnostic purposes.
 ...
PMID:[Histological changes in liver tissue in cholestasis]. 748 20

The lecture is devoted to the important scientific trends in study of chronic liver diseases (CLD): pathomorphosis, the role of slow viruses and immunity in the pathogenesis. Three main genetically closely interlinked forms of CLD--hepatitis, hepatosis, cirrhosis--are considered. Principal methods of treatment in various forms of CLD are also described. The conclusion about necessity of further exploration of the problem is made.
 ...
PMID:[The clinical picture, diagnosis and treatment of chronic liver diseases (a lecture)]. 820 25

In order to explore the specificity of serum bile acid (SBA) chromatograph in the diagnoses of different kinds of hepatosis, we investigated by means of gas chromatography the changes of serum bile acids in workers who exposed to hexogen or chloroethylene and in patients who suffered from hepatosis such as acute jaundice hepatitis, chronic active hepatitis, cirrhosis and liver cancer. The results revealed different disturbances of SBA occurring in the liver injuries induced by the two kinds of hepatotoxicant. Serum lithocholic acid (LCA), deoxycholic acid (DCA) and chenodeoxycholic acid (CDCA) in workers exposed to hexogen and wre significantly different from those of the control group respectively (P < 0.01, P < 0.01, P < 0.05); on the other hand, only serum LCA and DCA went up in workers exposed to chloroethylene (P < 0.0005, P < 0.001). The main changes both concentrated on the secondary bile acids. In acute jaundice hepatitis, chronic active hepatitis, cirrhosis and liver cancer, serum LCA, DCA, CDCA and cholic acids (CA) all went up in different degrees compared with the control group respectively (P < 0.005, P < 0.025, P < 0.005, P < 0.005). But no difference was noted among the 4 kinds of bile acids (P > 0.5), except that between CA and CDCA. These provided the evidence of the diagnosis and identification of clinical hepato-biliary diseases and occupational liver injures.
 ...
PMID:[Application of serum bile acid chromatography to the diagnoses of liver diseases]. 1068 67

An antilipidemic effect of poseidonol was tested in 123 patients with ischemic heart disease, stable angina of effort (II-III functional class), 40 patients with secondary pyelonephritis and 40 patients with chronic hepatosis-hepatitis associated with chronic alcoholism or diabetes mellitus. The patients had also hyperlipidemia. A positive effect of poseidonol was established: cholesterol content fell by 25.4, 20.6 and 18.7%, respectively; triglycerides level decreased by 63, 42 and 21.4%, respectively; B-lipoproteins fell by 55.5, 36.9 and 13.1%, respectively. High density lipoproteins rose by 40.2, 27 and 69.9%, respectively. No adverse effects either on the liver or kidney functions were observed.
 ...
PMID:[Poseidonol in the treatment of patients with hyperlipidemia]. 1122 Aug 93

Analysis of the effects of retinol acetate on LPO processes in vivo revealed antioxidant effects under normal conditions and during experimental free-radical pathology (toxic hepatosis-hepatitis). The concentration inversion of antioxidant effects of retinol acetate into prooxidant effects were observed only under normal conditions.
...
PMID:In vivo analysis of antioxidant and prooxidant properties of retinol acetate. 2431 53


<< Previous 1 2