Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0019158 (hepatitis)
 30,205 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

As many as 132 children with verified virus hepatitis were examined. Cortisol content in blood serum was measured and the parameters of cellular-humoral immunity were determined over time in the acute period and in the catamnesis up to 1 year. In the cyclic self-limiting forms of hepatitis B, the children developed immunologic unbalance with progressive hypercortisolemia, being an adequate reaction of the stressor systems and not requiring prednisolone administration. In protracted and chronic persistent hepatitis, the children developed immunosuppression and monotonous hypercortisolemia requiring short-term prednisolone treatment. The children afflicted with the grave and malignant forms of hepatitis B demonstrated, within the early times of the disease, secondary immunodeficiency and a considerable drop of cortisol content, demanding early prednisolone administration.
 ...
PMID:[Cortisol level and immunosuppression in viral hepatitis B in children and the approach to its treatment with glucocorticoids]. 278 67

Reactivation of hepatitis B virus (HBV) replication in hepatitis B surface antigen (HBsAg)-positive patients is associated with immunosuppressive therapy. However, the interactions between endogenous glucocorticoid in Cushing's syndrome and HBV-related hepatitis remain unclear. Here, we describe the management of a 32-year-old male HBV carrier with Cushing's syndrome caused by an adrenal cortical adenoma, who developed severe hepatitis B. Repeated episodes of septicemia resulting from hypercortisolemia-related immunosuppression further compromised his hepatic condition. Adrenalectomy could not be performed due to coagulopathy. Lamivudine was not available at that time in Taiwan, and this patient died of hepatic failure and sepsis. At autopsy, his liver showed submassive necrosis with small regenerative nodules. The hepatocytes were positive for HBsAg (membrane and cytoplasmic) and hepatitis B core antigen (nuclear and cytoplasmic). Screening for HBsAg is of crucial significance for immunocompromised individuals. Once positive HBsAg is detected in immunosuppressed patients, liver function and viral status should be closely monitored to enable earlier diagnosis and prompt treatment with the newer nucleoside analogues that actively fight HBV.
 ...
PMID:Submassive liver necrosis in a hepatitis B carrier with Cushing's syndrome. 1209 9

A 34-year-old female patient complaining of general fatigue and liver dysfunction was diagnosed as acute aggravation of chronic hepatitis B. She showed a complication of Cushing's disease and hepatitis was initially treated with lamivudine administration as well as inhibition and supplementation of cortisol, because hypercortisolemia could induce massive liver necrosis with hepatitis. After inducing remission phase, Hardy's operation for pituitary microadenoma was scheduled. Induction and maintenance of anesthesia were achieved by administration of propofol and analgesia was attained by intermittent administration of fentanyl. Liver function was well maintained during perioperative period and no complication concerning anesthesia was observed.
 ...
PMID:[Anesthesia for a patient with Cushing's disease and hepatitis B]. 1854 7