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Query: UMLS:C0019158 (hepatitis)
 30,205 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The Tyzzer's disease organism was grown in primary monolayer cultures of adult mouse hepatocytes prepared by collagenase perfusion. The organisms produced a plaque-like cytopathic effect involving almost the whole culture around 72 h post-infection when the bacterial growth reached a maximum. The organisms showed specific immunofluorescence, and electron microscopy revealed that intracellular organisms had peritrichous flagella and underwent cell division. After intravenous inoculation of the infected cell culture into mice, necrotic hepatitis was produced and the organisms, recovered from the liver lesion, could be propagated in primary culture of mouse hepatocytes.
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PMID:Growth of Tyzzer's organism in primary monolayer cultures of adult mouse hepatocytes. 634 4

Light and electron microscopic examinations were performed on tissues from 12 young mice which were affected by naturally-occurring Tyzzer's disease. Eight of the 12 mice had cardiac lesions which have not previously been reported in mice and which caused a high mortality. The cardiac lesions were detected in mice which had severe and advanced intestinal lesions which penetrated the deeper mucosa and muscular layer with active regeneration of the mucosal epithelium. Periodical serological tests to monitor the bacterial and viral status of this colony showed that it was free of other agents of murine disease such as mouse hepatitis virus, Corynebacterium kutscheri and Salmonella spp. until the onset of Tyzzer's disease and that no mixed infection occurred at the onset. It is considered that an advanced intestinal lesion is essential for the formation of cardiac lesions in Tyzzer's disease in mice.
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PMID:Naturally occurring Tyzzer's disease in a clean mouse colony: high mortality with coincidental cardiac lesions. 664 51

A naturally occurring case of Tyzzer's disease due to infection with Bacillus piliformis in a wolf-dog hybrid resulted in widely disseminated lesions, including severe myocarditis, hepatitis, enterocolitis, intestinal leiomyositis, and adrenal cortical adenitis. Previously reported lesions for canine Tyzzer's disease have been limited to hepatic necrosis and a necrotizing enterocolitis.
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PMID:Naturally occurring Tyzzer's disease in a puppy. 772 99

Tyzzer's disease, caused by Bacillus piliformis and characterized by a multifocal, necrotizing hepatitis was diagnosed in a 25 days old, male, German warmblood foal. The animal was submitted to the clinic of horses because of colic symptoms and a severe depression. Upon arrival it was comatose, recumbent and showed opisthotonos. Due to a severe, metabolic acidosis and a rapid progression of the disease, the foal was euthanatized. In immediately formalin-fixed tissue samples Bacillus piliformis was detected in the cytoplasma of hepatocytes by different histological techniques (Giemsa stain, silver impregnation technique by Warthin-Starry, immunohistology). This case is discussed within a literature review.
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PMID:[Infection with Bacillus piliformis (Tyzzer's disease) in foals]. 846 78

We noted naturally occurring infection with Clostridium piliforme (Tyzzer's disease) in 2 captive-reared cotton-top tamarins (Saguinus oedipus). Spontaneous Tyzzer's disease has been reported in multiple species of laboratory, domestic, and wild animals but is extremely rare in humans and nonhuman primates. Distinct from idiopathic colitis, which is common in cotton-top tamarins, these 2 tamarins had severe, transmural, necrotizing typhlocolitis accompanied by myocarditis and hepatitis. Abundant bacteria compatible with C. piliforme, the etiologic agent of Tyzzer's disease, were present adjacent to lesions in the cecum-colon, liver, and heart. Therefore, colitis caused by C. piliforme, although rare, should be included as a differential diagnosis in cotton-top tamarins and as a cause of postnatal mortality in this species.
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PMID:Naturally occurring Tyzzer's disease in cotton-top tamarins (Saguinus oedipus). 1734 1