Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0019158 (hepatitis)
 30,205 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Quantitative determination of the abnormal plasma lipoprotein of cholestasis LP-X has been performed in 81 LP-X positive patients with different liver disorders. Great variations in the plasma concentration of LP-X were demonstrated both in the 45 patients with intrahepatic cholestasis (acute hepatitis, toxic hepatitis, primary biliary cirrhosis and cholangitis) and in the 36 patients with extrahepatic cholestasis (extrahepatic biliary obstruction by tumours and choledocholithiasis). The plasma concentratkons of LP-X in the patients with extrahepatic cholestasis (median 158 mg/100 ml) were significantly (psmaller than 0.001) higher than in the patients with intraphepatic cholestasis (median 25 mg/100 ml) was exceeded by 42% of the patients with extrahepatic biliary obstruction, and 33% of the patients with extrahepatic biliary obstruction, had LP-X LEVELS ABOVE 400 MG/100ML. The plasma concentration of LP-X was significantly correlated to the plasma activity of alkaline phosphatases and serum bilirubin, but seemed to be superior to these two parameters in the differentiation between intrahepatic and extrahepatic cholestasis. Plasma levels of LP-X above 400 mg/100 ml are highly indicative of extrahepatic biliary obstruction.
 ...
PMID:Quantitative determination of the abnormal lipoprotein of cholestasis, LP-X, in liver disease. 16 86

Two previously healthy adults with acute granulomatous hepatitis attributable to cytomegalovirus (CMV) monucleosis had prolonged fever, heterophil-negative lymphocytosis with numerous atypical forms, minor alterations in hepatic function, and evidence on biopsy, of a nonspecific acute hepatitis with granulomata. Infection with CMV was corroborated by a rising titer of complement-fixing antibody in case 1 and by a high titer of antibody that later fell in case 2. It is important to exclude CMV ivfection as an etiologic factor in cases of acute granulomatous hepatitis and fever of unknown origin.
 ...
PMID:Acute granulomatous hepatitis. Occurrence in cytomegalovirus mononucleosis. 16 2

Day-old to 4-week-old mice from a breeder colony which had been seromonitored to be free from mouse hepatitis virus infection, were tested for susceptibility to the virus by different routes of inoculation. After intraperitoneal, intravenous and intracerebral inoculation of 10(2) or more plaque-forming units of the virus, mice of all ages died of acute hepatitis. While day-old mice died also after subcutaneous, intranasal and peroral routes of inoculation, those 3 weeks or more of age resisted to infection by these routes. To intranasal inoculation mice 1 and 2 weeks of age were fully susceptible but some of the resisted to peroral inoculation. In the course of non-fatal infection in 4-week-old mice after intranasal inoculation, viremia and production of some hepatic lesions were recognized and infection became fatal in association with cortisone treatment. The results suggested that the intranasal route of infection may be of importance for spreading of infection in mouse breeding colonies in which inapparent infection is prevailing.
 ...
PMID:Pathogenicity of mouse hepatitis virus for mice depending upon host age and route of infection. 17 65

Frequent occurrence of post-transfusion hepatitis continues despite screening for Australia antigen in blood before transfusion and elimination of commercial donor sources. The majority of these cases appears unrelated to hepatitis B virus. Preoperative, acute, and convalescent serra were screened for evidence of hepatitis B, hepatitis A, Epstein-Barr, and cytomegalovirus exposure in 34 cardiac surgery patients developing post-transfusion hepatitis postoperatively. Four patients showed evidence of hepatitis B infection and 3 patients developed significant antibody titer rises to cytomegalovirus. No patient showed evidence for acute hepatitis A infection postoperatively in response to blood transfusions. Epstein-Barr virus was also not responsible for any cases of post-transfusion hepatitis. Presently available laboratory methods failed to implicate hepatitis A, Epstein-Barr, or cytomegalo-virus in the majority of non-B post-transfusion hepatitis cases. This suggests that identification and characterization of additional hepatitis-producing agents will be required to define further the epidemiology of post-transfusion hepatitis and develop measures for its prevention.
 ...
PMID:Etiological spectrum of post-transfusion hepatitis. 17

Seroconversion was observed in 6 patients, indicating an infection with hepatitis virus B. All of these patients had been hospitalized with HBAg-positive persons a few weeks before, 5 of them because of acute hepatitis type A. While seroconversion was followed by acute hepatitis in 4 cases, the infection remained clinically silent in the other two patients. The second periods of illness were no attacks of relapsing hepatitis type A, as was indicated by HBAg. Vice versa superinfection of hepatitis B-patients with hepatitis virus A may occur, as is discussed in another case. Acute hepatitis is often transmitted in hospitals. Infective routes are discussed and means are described, by which is attempted, to reduce the incidence of hospital-acquired hepatitis.
 ...
PMID:[Hospital-acquired hepatitis type B. Report of 6 cases (author's transl)]. 17 49

Virus-like particles, acute hepatitis, hepatitis type C. Intranuclear virus-like particles were found by electron microscopy in liver cells of a woman suffering from mild HBsAG- and IHxAG negative acute hepatitis. The particles encountered were morphologically different from those found in hepatitis B and hepatitis A respectively. Futher studies are required to clarify whether the structures represent an incidental finding of a new human (passenger) virus or they may be related to the aetiological agent of the supposed hepatitis type C.
 ...
PMID:Intranuclear virus-like particles in HBsAG- and IHxAG-negative acute hepatitis (type C?) (Preliminary report). 18 Jul 61

No acute cases of clinical or anicteric hepatitis were in observed in 75% of 161 patients who had been exposed to hepatitis A by an oral surgeon during the contagious period. Three cases of liver dysfunction of indeterminate cause did occur, although at least two could be attributed to multiple abuses of drugs 3-5 and not to exposure to hepatitis. The fact that hepatitis A did not spread in this instance suggests that oral surgeons who are ill with acute hepatitis A do not necessarily transmit the disease to their patients. Epidemiologic investigations of similar situations will undoubtedly augment this preliminary data.
 ...
PMID:Hepatitis type A in an oral surgeon: a prospective study of contacts. 18 49

In 50 patients with acute hepatitis serum lipide and lipoproteins were determined at regular intervals and the results were compared with the usual liver function tests. Australia-antigen was established in 26 patients. During the first three weeks of the disease the most striking finding was a significant increase in the triglycerides, which was most pronounced at the end of the second week. Triglyceride levels usually returned to normal during the fourth week. In the course of the disease, lipoprotein electrophoresis showed marked decrease or absence of alpha- and pre-beta-lipoproteins during the first two weeks. During the third week faint alpha and pre-beta bands recurred in most patients. By the end of the fourth week lipoprotein electrophoretic findings were back to normal. There was general correlation between routine tests of liver function and results of lipid analyses throughout the course of the disease. This typical pattern of serum lipid and lipoprotein changes was found with near-consistency in patients with HAA-positive hepatitis. It was also present in the majority of HAA-negative patients, though in these the characteristic discrepancy between hypertriglyceridemia and simultaneous decrease of the pre-beta-lipoprotein band in eletrophoresis was, on the average, absent.
 ...
PMID:[Changes in serum lipids and lipoproteins in acute hepatitis]. 18 24

A study was performed to establish the value of immune adherence haemagglutination tests for antibody to hepatitis A virus in the diagnosis of non-B hepatitis. Infection with hepatitis A virus was confirmed in 14 out of 16 patients from six families and seven out of nine patients in whom the source of infection was unknown. One additional patient, who had had two episodes of jaundice, was shown to have had an attack of hepatitis A followed by an attack of hepatitis B. In patients with acute hepatitis A antibody detectable by immune adherence haemagglutination becomes detectable three or four weeks after the onset of symptoms and reaches peak levels about five weeks later.
 ...
PMID:Non-B hepatitis in Melbourne: a serological study of hepatitis A virus infection. 18 15

Liver protocallagen proline hydroxylase activity (PPH activity) was determined in patients with various liver diseases, CCl4-induced liver fibrosis rats and cholin deficiency (tcd) fatty liver rats. The following results were obtained: Liver PPH activity in patients with chronic hepatitis was higher than that in patients with acute hepatitis, while the activity in patients with liver cirrhosis was much higher than that in patients with chronic hepatitis. The activity was higher in patients with chronic active hepatitis than in those with chronic inactive hepatitis. Patients with active and progressive liver cirrhosis were found to have an especially high PPH activity, in whom the activity reflected well the degree of liver fibrosis. Even though fibrosis in persistent hepatitis was almost negligible or slight, the degree of liver PPH activity in persistent hepatitis was similar to that in liver cirrhosis. Liver PPH activities in CCl4-induced liver fibrosis rats and CD fatty liver rats elevated proportionally to the lapse of time. Whilst liver PPH activity in rats of CD fatty liver without fibrosis in 23 to 31 weeks after the start of the experiment was slightly lower than that in rats of CD fatty liver with fibrosis. But liver PPH activity of the former was considerably higher than that of control rats.
 ...
PMID:Liver protocollagen proline hydroxylase in human liver diseases and experimental liver fibrosis. 19 57


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>