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Query: UMLS:C0019158 (hepatitis)
 30,205 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Reports of cases of primary and secondary syphilis are increasing in the United States, particularly in urban areas and among homosexual men. While primary syphilis poses little diagnostic difficulty, many physicians are unfamiliar with the multisystem nature of secondary lues. Patients who have secondary syphilis commonly present with systemic signs, skin rash, mucous membrane lesions and generalized adenopathy. Less commonly, secondary syphilis may occur as acute meningitis, sensorineural hearing loss, iritis, anterior uveitis, optic neuritis, Bell's palsy, gastropathy, proctitis, hepatitis, pulmonary infiltration, nephrotic syndrome, glomerulonephritis, periostitis, tenosynovitis and polyarthritis. The diagnosis of secondary syphilis is easily confirmed. Its various manifestations are readily treated with penicillin and, if treated early, are entirely reversible. Two recent cases of secondary syphilis, one presenting as nephrotic syndrome and one as chorioretinitis and ptosis, illustrate the usual and unusual features of this common infection.
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PMID:Secondary syphilis: uncommon manifestations of a common disease. 670 90

100 patients with acute viral hepatitis were examined. In 10 of these the infection was found to be associated with homosexual activity and in 7 with promiscuity. Sexual intercourse was a likely cause of infection in 61% of all men aged from 20-40 years who had contracted hepatitis B by a non-parenteral route. Of these patients, 8 had acute syphilis and 2 had acute gonorrhea along with their hepatitis. The clinical course of the hepatitis was more severe in the group of syphilitic patients than in the controls. These observations indicate that simultaneous venereal disease influences the incidence and course of acute viral hepatitis.
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PMID:[Acute virus hepatitis and venereal infection (author's transl)]. 679 27

Most studies of sexually transmitted diseases in homosexual men have examined prevalence in clinic populations; for comparative purposes, we analyzed data from a survey of 4,329 gay men conducted in 1977. Among 4,212 respondents to the self-administered questionnaire, 66.8 per cent reported previous infection with pediculosis; 38.4 per cent, gonorrhea; 24.1 per cent, nonspecific urethritis; 18.1 per cent, venereal warts; 13.5 per cent, syphilis; 9.7 per cent, hepatitis; and 9.4 per cent, herpes. Number of different lifetime sexual partners best predicted histories of symphilis (r = .249), gonorrhea (r = .402), and the other diseases; frequency of checkups, years as a practicing homosexual, and furtive sexual activities were among the many other significant correlates of venereal infections. Respondents most often sought examinations from private physicians (39.4 per cent); those who visited gay clinics were examined most often and felt most positive about their medical care. Gay men who participated in the survey reported frequent infections with many of the same sexually transmitted diseases often seen in private medical practices, public VD clinics, and gay health centers. Since high rates of disease are related to large numbers of different partners, frequent exposures with anonymous contacts, and anal intercourse, we recommend frequent examinations for those whose life-styles include these characteristics.
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PMID:The gay report on sexually transmitted diseases. 689 4

The antenatal diagnosis of fetal ascites by ultrasonography is possible by the typical finding of a zone free of echos in the fetal abdomen. Among 7,833 newborns 2 live born infants with fetal ascites were observed. The fetal prognosis can be improved by early diagnosis and differential diagnostic tests during the pregnancy. The antenatal diagnosis includes a search for hydrops, congenital anomalies of the heart, anomalies of the lower urinary tract, intra-abdominal calcifications and diagnosis of the sex. Infectious causes such as syphilis, toxoplasmosis, cytomegaly and hepatitis must be excluded. Delivery may have to be by cesarean section paracentesis of the fetal ascites through the maternal abdominal wall may be necessary. A neonatalogist must be present at birth. The neonatal diagnosis of the ascites starts with a flat plate of the abdomen in search of calcifications, bowel distensions, and pneumoperitoneum. Intravenous pyelogram and cystography show urine-ascites which has the best therapeutic prognosis. The investigation should be finished within 12 hours after birth. Acute respiratory distress may require neonatal paracentesis.
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PMID:[The antenatal ultra-sonic diagnosis of ascites in the newborn (author's transl)]. 691 Apr 52

The author examines and rejects the claims of researchers involved in two well-known studies, the Tuskegee study of untreated syphilis in poor blacks and the Willowbrook experiments with hepatitis in institutionalized retarded children, that these were "studies in nature" in which the researchers were only passive observers of a natural phenomenon. He further argues that the research designs were unethical and that, in attempting to take advantage of conditions of overwhelming social deprivation, the researchers incurred an obligation to attempt to relieve the sufferings of their subjects.
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PMID:Were Tuskegee & Willowbrook 'studies in nature'? 709 65

Liver involvement is uncommon in secondary syphilis and may resemble liver disease from alcoholism or acute viral hepatitis. Liver biopsy usually indicates nonspecific reactive hepatitis with or without cholestasis. Jaundice may sometimes be absent although liver damage is present. The liver abnormalities can be resolved with antibiotic therapy, but penicillin therapy may cause Jarisch-Herxheimer reaction. Syphilitic hepatitis should be considered in the differential diagnosis of obscure liver disease.
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PMID:The liver in secondary syphilis. 712 42

Two patients are presented as cases of secondary syphilitic hepatitis. Clinical and biological signs coincided with usual description of this affection. Syphilitic serological tests were all very positive. These two patients were homosexual men. In one case, we have found treponema in hepatic biopsy, underelectron microscope only, which confirmed the diagnosis. Evolution of both patients was improved by anti-syphilitic penicillin the rapy. Thus, this is an important diagnosis, which should not missed, because of the good prognosis of this affection with specific treatment, and because of the increasing frequency of syphilis for 20 years.
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PMID:[Early syphilitic hepatitis. Two cases]. 717 Nov 82

Hepatitis C virus (HCV) has an etiological role in post-transfusional Non-A Non-B Hepatitis, cirrhosis, and hepatoma. Studies have revealed an high prevalence of anti-HCV antibodies in hemophiliacs, IV drug users, and other groups at risk for parenterally transmitted infections. The authors report findings from their investigation into the sexual transmission of HCV. The prevalences of antibodies to HCV, the hepatitis B core (HBc) antigen, and to Treponema pallidum were assessed among groups of individuals at high and low risk for sexually transmitted diseases (STD). The population at low risk for STDs was comprised of 2494 volunteer blood donors at the Hospital Universitario Clementino Fraga Filho (HUCFF) over the period July-November 1990. The population at high risk for STDs was comprised of 187 adults consecutively enrolled between September 1990 and January 1991 in a cohort study of the natural history of HIV infection. Sera were screened with a first generation HCV ELISA test, with repeat reactive samples further analyzed using a second generation recombinant immunoblot confirmatory test (RIBA-2). Data on the presence of antibodies to HBc, VRDL, and HIV were abstracted from the Blood Bank records. Antibody testing against Treponema pallidum was conducted among HCV-ELISA positive blood donors and their controls using FTA-ABs. 2.08% of blood donors were infected with HCV, 7.96% of the HIV-infected homosexuals, and 8.02% of the whole group with sexually acquired HIV infection. Anti-HBc antibodies were more frequently present in anti-HCV RIBA-2 confirmed positive blood donors than in controls. 33.3% of the HCV-positive blood donors and 11.04% of controls were found to be anti-HBc positive. 17.6% of HCV-positive donors and 4.9% of controls yielded positive FTA-ABs results. 5.9% of samples from blood donors were both anti-HBc and FTA-ABs positive, while none of the controls reacted in both tests. The association between HCV, hepatitis B infection, and syphilis in individuals at low risk for parenterally transmitted diseases suggests that sexual transmission contributes to the maintenance of the endemicity of HCV in the local population.
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PMID:Prevalence of antibodies to hepatitis C virus in populations at low and high risk for sexually transmitted diseases in Rio de Janeiro. 750 22

Since some hepatitis viruses and the human immunodeficiency viruses share common modes of transmission, such as the sexual route, we undertook to investigate the prevalence of antibodies to these and other pathogens among 384 rural pregnant women. Our study was intended to form the basis of infection management policies in pregnancy. Antibodies and other markers of the hepatitis A, B, C, and D viruses (HAV, HBV, HCV, HDV), the human immunodeficiency virus type 1 (HIV-1) and Treponema pallidum were sought. We tested for antibodies to the viruses using the appropriate enzyme-linked immunosorbent assays. HCV and HIV-1 infection were confirmed using standard immunoblotting techniques. Regarding HBV, we tested for the surface antigen (HBsAg), antibody to the surface antigen (anti-HBs) and antibody to the core antigen (anti-HBc). A non-specific test, the rapid plasma reagin test (RPR), was used for estimating Treponema pallidum (syphilis) infection. We found an overall prevalence of antibodies to HAV of 91.4%, to HCV of 6.8%, to HDV of 0%, and to HIV-1 of 3.5%. We found no IgM antibodies to HAV. The incidence of HBV markers was as follows: 5.4% for HBsAg, 61.3% for anti-HBs, and 84.6% for anti-HBc. RPR reactivity was found in 15.8% of the women. These results will be used to establish appropriate management and preventative policies for women attending the antenatal clinic. Prevention and appropriate early treatment of infections in these women will be considered.
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PMID:Seroprevalence of hepatitis and HIV infection among rural pregnant women in Cameroon. 752 47

Implementation of the Safe Motherhood initiative in India calls for the institution of good prenatal care for all women. The first aspect of prenatal care is collecting the patient's history and reviewing the health history of her family. The physical examination should include inspection for reproductive tract diseases, a bimanual examination early in pregnancy to correlate the size of the uterus and the reported last menstrual period, and routine abdominal palpation. Ultrasonography should be performed at least once. Laboratory tests should include analysis of hemoglobin and hematocrit levels, urine analysis, blood grouping and Rh typing, serological tests for syphilis, antibody screening and screening for rubella and hepatitis antigen, and cervical cytology. Additional screening and genetic testing may be necessary in certain cases. Women with no complications should be seen once a month for 28-30 weeks, once every two weeks until 36 weeks, and once a week thereafter. High-risk patients should be seen more frequently. Infections detected during pregnancy must be properly treated with antibiotics, although, in general, women should avoid medications during pregnancy. In India, hematinics and vitamins should be given to all pregnant women. Drugs and substances to be avoided during pregnancy include tetracycline, chloramphenicol, streptomycin, cotrimoxazole, diuretics, alcohol, trimethadone, warfarin, lithium, quinine, sex hormones, anesthetics, tobacco, vitamin D, and all live vaccines except BCG. Common sense should dictate the safe level of activity for a pregnant woman.
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PMID:Role of antenatal care in safe motherhood. 765 37


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