Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019158 (hepatitis)
 30,205 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

CMV infection is one of the major infection after bone marrow transplantation. CMV viremia was systematically studied in 66 patients with aplastic anemia or leukemia undergoing BMT. 57% patients had CMV viremia with a frequency peak between 7 and 9 weeks after transplant. Clinical symptoms found during viremia were pancytopenia, fever, cytolytic hepatitis. Interstitial pneumonitis was found only in 4 cases. In 3 cases, viremia was not associated with clinical symptoms. Survival was identical to the group of patients without viremia. Viremia was positively associated with the presence of high anti-CMV antibody titer in donor or recipient before transplant, or to a lymphocyte proliferative response against CMV antigens in donor or recipient before BMT. Granulocyte transfusions increased the frequency of CMV viremia. CMV infection was significantly associated with acute and chronic graft versus host disease. The relation showed between these parameters and viremia provides a basis for an accurate diagnosis of CMV infection and a better background for the study of prophylactic or curative treatment of CMV infection.
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PMID:[Clinical aspects of cytomegalovirus infection after allogenic bone marrow grafts]. 609 Dec 25

The incidence of haematological abnormalities has been evaluated in 1170 patients affected by acute viral hepatitis. Of these patients, 665 were HBsAg+, 427 HBsAg-, 31 with IgM anti-HAV, 26 non A and non B hepatitis. 21 patients were not classified due to lack of data relating to markers for HAV or HBV. Anemia, leucopenia, thrombocytopenia and pancytopenia were found with some frequency at the haemochromocytometric examination. It is emphasized that these haematological abnormalities are often of minor relevance whereas the rarer and more serious complications such as persistent bone marrow hypoplasia or pure aplastic anemia can present difficult clinical problems regarding prognosis and therapy: in 4 cases of bone marrow hypoplasia a recovery was obtained in 1 case only, whereas the remaining cases had a fatal outcome after a period varying from 20 days to 15 months from the appearance of pancytopenia. We suggest the advisability of a closer study of the haematological and immunological aspects in patients with viral hepatitis in order to discover those elements which are useful towards a better understanding of the etiopathogenesis of the haematological abnormalities studied above. Such a detailed study would also enable further improvement in existing therapeutic measures.
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PMID:[Hematological complications of viral hepatitis. Case-list contribution]. 644 May 80

Histiocytic medullary reticulosis (HMR) was originally defined as a neoplastic disorder. Some cases reported as HMR have been characterized by a systemic proliferation of mature histiocytes showing hemophagocytosis, bone marrow necrosis, pancytopenia, hepatitis, and coagulopathy. Clinically, these patients have fever and constitutional symptoms and often have hepatosplenomegaly and lymphadenopathy. Although there is a high mortality rate, this process appears to be reactive and has been associated with active viral infection. Similar cases have been briefly described that were associated with other agents or disease processes, but concomitant viral infections were not excluded. Three characteristic examples of this hemophagocytic syndrome that were associated with bacterial sepsis are described. Active infection by those viruses that have previously been associated with the syndrome was excluded. It appears that the hemophagocytic syndrome may be associated with various types of active disseminated infections.
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PMID:Bacteria-associated hemophagocytic syndrome. 649 70

To illustrate the etiologic role of drugs and chemicals in the development of aplastic anemia, we analyzed 108 cases of aplastic anemia among 3,715 hematologic patients during a ten-year period at the hematology section of Istanbul Medical School. Among these 3,715 patients, 695 had leukemia, a result indicating the relative rarity of aplastic anemia as compared with leukemia. Of the 108 patients, 58.3% were male and 41.7% were female. Their ages ranged from six months to 82 years. Pancytopenia was severe in 42.6% of the patients, and moderate or mild in 57.4%. Bone marrow was hypocellular in 84 patients, normocellular in 16, and hypercellular in eight. In 52 (48.1%) of the patients with aplastic anemia, the following etiologic factors were implicated: benzene (25 patients), antirheumatic drugs (ten), chloramphenicol (four), chloramphenicol plus hepatitis or chromosome anomalies (two), thiamphenicol plus sulfonamide (one), antituberculous drugs (three), daraprim (three), insecticides (two), hepatitis (one), and sulfonamide (one). Data indicate that the degree of bone-marrow cellularity is not always related to functional capacity, and numerous agents may have etiologic roles in the development of aplastic anemia.
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PMID:Aplastic anemia due to chemicals and drugs: a study of 108 patients. 652 15

A combination therapy consisting of daily intrarectal administration of 1,500 mg of FT-207 suppository, daily or every three day bladder instillation of 40 mg adriamycin for a total of 20 applications, and once per week intramuscular administration of 5 KE OK-432 was described. The therapy was performed in 30 cases of advanced bladder cancer. The effectiveness evaluated by Karnofsky's criteria was as follows: 8 cases of 0-0, 2 of 0-A, 1 of 0-B, 2 of 0-C, 7 of 1-A and 10 of 1-B, showing an effective rate of 57%. Local pain was observed in 20 cases (67%), pancytopenia in 1 (3%), hepatitis in 4 (13%), stomatitis in 5 (17%) and anorexia in 6 (20%). From this clinical trial, it is presumed that combination therapy administering FT-207 intrarectally, adriamycin intravesically and OK-432 intramuscularly might be used for the treatment of advanced bladder cancer provided sufficient care is taken of general side effects.
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PMID:Immunochemotherapy for advanced bladder cancer using FT-207, adriamycin and OK-432. 681 68

We describe the clinical course of three cytomegalovirus-antibody-positive allogeneic marrow graft recipients who developed progressive pancytopenia during the third month post-transplant. Bone marrow biopsy cores were hypocellular without evidence of disease recurrence. Haemopoietic progenitor assays demonstrated a decrease of all assayable progenitors. Cytomegalovirus was identified from the blood and urine of all three patients. However, none of the patients developed other manifestations of cytomegalovirus infection such as pneumonitis, hepatitis and enteritis. The therapeutic use of ganciclovir and intravenous immunoglobulins resulted in prompt resolution of both viraemia and viruria in all three patients, and of pancytopenia in two patients.
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PMID:Pancytopenia in allogeneic marrow transplant recipients: role of cytomegalovirus. 794 79

A 37-yr-old woman with RF-positive RA developed cholestatic hepatitis after 10 days of D-penicillamine therapy. This was discontinued immediately. The cholestasis persisted for the remaining 14 months of her life. Severe hypercholesterolemia developed with xanthelasmata and eventually pancytopenia, which was caused by a massive infiltration of the bone marrow by lipid-containing foam cells. The patient died of sepsis. Review of the literature shows intrahepatic cholestasis to be a rare and idiosyncratic complication of D-penicillamine therapy. To our knowledge, ours is the first documented case of persistent cholestatic icterus.
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PMID:Fatal cholestatic hepatitis caused by D-penicillamine. 805 7

Systemic lupus erythematosus (SLE) and primary biliary cirrhosis (PBC) are distinct clinical disorders which rarely occur in the same patient. We report on a 65-year-old woman with coexistence of both conditions. Diagnosis of SLE was ascertained by the presence of seven ACR criteria (cutaneous lesions, photosensitivity, antinuclear and anti-double-stranded-DNA antibodies, pancytopenia, arthritis, oral lesions). PBC was disclosed by clinical investigation, liver histology and highly positive antimitochondrial M2 antibodies. The most important differential diagnoses of lupus hepatitis are PBC and autoimmune hepatitis. Diagnostic criteria for these conditions are discussed, and previous reports on overlap between SLE and PBC are reviewed.
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PMID:Unusual coexistence of systemic lupus erythematosus and primary biliary cirrhosis. 819 7

A 29-year-old male patient presented with acute liver failure from non-A, non-B and non-C hepatitis, necessitating orthotopic liver transplantation. After operation he developed progressive pancytopenia on the basis of aplastic anemia, which was probably hepatitis associated. After therapy with GM-CSF had failed, he underwent allogeneic BMT from his HLA genotypically identical brother following a conditioning regimen of CY 50 mg/kg x 4 and 500 cGy total lymphoid irradiation. He engrafted promptly but transfusion dependency did not resolve until CMV viremia was treated with ganciclovir. The patient is alive and well 2 years after BMT.
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PMID:Successful allogeneic bone marrow transplantation in an adult with aplastic anemia following orthotopic liver transplantation for non-A, non-B, non-C hepatitis. 827 44

Azathioprine can cause severe myelosuppression. The inherited activity of the enzyme thiopurine methyltransferase has been recently recognised as a major factor in the susceptibility to myelosuppression. Thiopurine methyltransferase deficiency occurs at a frequency of one in 300 and is associated with profound myelosuppression after a short course of azathioprine. Very low thiopurine methyltransferase activity represents the TPMTL/TPMTL genotype, and can be detected before therapy with azathioprine is started. We describe the first documented case of azathioprine-induced severe myelosuppression due to thiopurine methyltransferase deficiency in autoimmune liver disease. The azathioprine dose was low (1 mg/kg) and pancytopenia occurred after 56 days therapy. It would be advisable to measure thiopurine methyltransferase activity before patients with autoimmune hepatitis are exposed to azathioprine.
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PMID:Azathioprine-induced myelosuppression due to thiopurine methyltransferase deficiency in a patient with autoimmune hepatitis. 855 Oct 1


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