Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019158 (hepatitis)
 30,205 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Mycotoxicoses involving horses, rabbits and cattle have been studied. Fusarium tricinctum and T-2 toxin were isolated from all incriminated feedstuffs. Other isolated trichothecenes from the feed included HT-2, verrucarins and roridin. The toxins were separated, identified and quantitated using thin-layer chromatography, gas-liquid chromatography and mass spectrometry. T-2 toxin was detected in amounts varying from 0.5-204 ppm. The contaminated feedstuffs in connection with the affected horses and rabbits, included cereal grains (corn, cornstalks, bran and barley), whereas fescue hay was associated with the mucocutaneous findings in the bovine episode. The effects of the toxin(s) seemed to be host specific and varied according to the different animal species. Horses and rabbits developed primarily central nervous disorders with conspicuous pathological findings in the brain. Hepatitis and nephritis were also seen in naturally intoxicated horses and experimentally fed rats. Affected cattle developed mucocutaneous eruptions around the mouth and nostrils. In addition, dermonecrotic findings were observed involving the extremities, ear and tail. Fusariotoxicoses are toxic conditions of farm animals and man caused by the ingestion of cereal grains and forages contaminated by different fungal species of the genus Fusarium. A variety of clinical and pathological findings have been reported (5,6,10,13,15,17,31). This study concerns neuropathic findings in horses and rabbits and mucocutaneous lesions in cattle in association with T-2 toxin contamination.
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PMID:Fusariotoxicoses of farm animals and mycotoxic leucoencephalomalacia of the equine associated with the finding of trichothecenes in feedstuffs. 372 49

A 34-year-old male presented with fulminant hepatitis A associated with acute renal failure. The patient was admitted four days after flu-like symptoms developed. Physical examination was unremarkable except for icteric sclerae. Laboratory studies showed SGOT 10719 U/l, SGPT 5780 U/l, prothrombin time 22%, BUN 25.5 mg/dl, and creatinine 2 mg/dl. Serum complements were within normal ranges, and circulating immune complexes were not detected. Anti-HAV IgM was positive. He developed hepatic coma on the fourth hospital day, and his renal function deteriorated progressively. He was treated with hemodialysis, but there was no improvement in consciousness. Although acute liver failure improved, he died on the 74th hospital day of subendocardial infarction. Autopsy examination showed acute renal tubular necrosis. The liver was enlarged and was in the residual stage of acute hepatitis without submassive necrosis. The development of fulminant hepatitis in hepatitis A has been rare, but in recent years acute renal failure in hepatitis A has been reported. Although the mechanisms responsible for renal failure in liver diseases are uncertain but could be multifactorial, immune complex-mediated nephritis and/or endotoxemia have been considered.
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PMID:Report of a case with fulminant hepatitis A associated with acute renal failure. 407 29

A considerable number of Chinese medical herbs have been found to be anti-inflammatory upon screening for the inhibition of acute inflammation and allergic reaction, and for the suppression of adjuvant arthritis. Most of this research has been published exclusively in Japanese, and consequently is little known internationally. In this review, we will introduce the most recent conclusions drawn from current pharmacological research on the anti-inflammatory action of various Chinese medicinal herbs being undertaken in Japan. Due to limitations of space, we mention only herbs showing anti-inflammatory activity in vivo when administered intra-orally, and having low toxicity. We will also introduce some popular Chinese medical prescriptions used in the treatment of arthritis, hepatitis and nephritis and attempt to explain their anti-inflammatory action resulting from the synergistic action of the herbs contained in these prescriptions. All references cited in this review were either written originally in English or have an English abstract.
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PMID:A pharmacological study of the anti-inflammatory activity of Chinese herbs. A review. 612 73

Report is given on a 68-year-old man who suffered primarily from progressive weight loss and repeated episodes of fever and arthralgia. Later, liver dysfunction and renal insufficiency developed. Liver and kidney biopsies disclosed granulomatous hepatitis and nephritis. Because of the morphologic and clinical findings, the diagnosis of Boeck's disease was made. Shortly before death, diarrhea developed. Autopsy revealed a massive systemic involvement in Whipple's disease proven by light and electron microscopy and immunofluorescence. Tuberculoid and epitheloid cell granulomas and isolated giant cells were found in addition to the biopsy findings in skeleton muscles, the small intestine, lymphnodes and bronchi. At autopsy, the kidney showed chronic interstitial nephritis. The literature of kidney involvement in Whipple's disease is reviewed. This is the first case with granulomatous interstitial nephritis and chronic renal insufficiency in an inadequately treated Whipple's disease.
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PMID:Chronic interstitial nephritis in Whipple's disease. 618 68

Five cases of the phenytoin syndrome are reviewed here. This hypersensitivity reaction is characterized by fever, eruption, lymphadenopathy, and hepatitis. Anemia, pharyngitis, diarrhea, and nephritis may also be associated. The skin eruption is pleomorphic, presenting as morbilliform eruptions, follicular papules and pustules, erythroderma, or toxic epidermal necrolysis. The management of these patients is made more difficult by the tendency for multiple relapses even after the use of phenytoin has been discontinued.
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PMID:The phenytoin syndrome. 622 59

Rabbits were injected by subcutaneous, intraperitoneal and intravenous routes with suspensions of motile zoospores of a Pythium sp. isolated from a subcutaneous lesion of a horse in north Queensland. Some animals injected by the subcutaneous route were also treated by cortisone injections. Animals in each group were found to be highly susceptible to infection. Injection by the subcutaneous route resulted in progressive granulomatous eosinophilic abscesses in all normal and cortisone-treated animals. Preferential hepatic invasion developing into severe necrotizing hepatitis was the most common lesion in the intraperitoneally injected group. In intravenously injected animals severe embolic mycotic nephritis was the principal lesion. A significant progressive leukocytosis with moderate neutrophilia and mild monocytosis was observed in the subcutaneously and intraperitoneally injected immune competent animals. Cortisone-treated subcutaneously injected animals did not develop a leukocytosis. Many of the cortisone-treated control animals showed increased susceptibility to bacterial infections while the cortisone-treated fungal-injected animals did not.
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PMID:Experimental pythiosis in rabbits. 665 27

The authors present a case of severe poisoning as a result of ingestion of a considerable amount of Carbon Tetrachloride, where toxic hepatitis and hepato-nephritis, neurological occurrences and sexual disturbances appeared. There was a considerable decline of the libido, complete impotence during several months. The accident occurred owing the ignorance of the instructions, unlabelled toxic material as such and not keeping it in a safe place. The Hamsin - a hot and dry wind - played an important part in the quick and severe appearance of the poisoning. The sexual disturbances which did not exist before the poisoning, appeared immediately after the intoxication. They were apparently connected with the injury of the liver cells; they are similar to those induced under the influence of other toxic materials. The general condition, including the sexual disturbances improved, and patient returned to his normal working condition after a period of nine months.
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PMID:[A case of carbon tetrachloride poisoning]. 667 5

Leptospirosis is still endemic in the Po valley. It has an extremely protean clinical picture. In a series of 79 cases diagnosed at Pavia in the period 1970-79 hepatonephritic forms were the most common (29.1%), followed by febrile or pseudo-influenza forms (25.3%), hepatitis (20.2%), nephritis (17.8%), and meningitis (7.6%). Febrile hepatonephritis was always accompanied by the most severe pictures. Timely antibiotic management with penicillin or ampicillin, and above all the early use of peritoneal dialysis (carried in 10 subjects) enable a final cure to be obtained even in these cases. The only death in that series did not appear to be ascribable to the disease itself.
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PMID:[Current clinical aspects of leptospirosis]. 667 98

A 24-year-old woman with systemic lupus erythematosus had, after reduction of corticosteroid therapy, a severe relapse of the disease with hepatitis, nephritis and pleurisy. After admission to the hospital, she was given 60-80 mg/day of prednisone and acute pancreatitis developed on the third day. Plasmapheresis, followed by injection of 1 g of methylprednisolone, was started. This combined therapy induced a prompt and complete recovery in a few days.
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PMID:Therapy of acute pancreatitis in systemic lupus erythematosus with plasmapheresis and corticosteroids. 668 Nov 52

Studied were morphologically the organs of 10 cattle originating from two provinces of Cuba that suddenly succumbed ( muerte subita ). There were hemorrahagic diathesis, and histologically--general activation of the reticulo-endothelial system, nonsuppurative encephalomyocarditis, interstitial nonsuppurative hepatitis, nephritis, and pneumonia as well as catarrhal hemorrhagic gastroenteritis. In all cases there were among the lymphoid proliferations diffusely disseminated eosinophile leukocytes ( hyperergia ). This finding showed that the disease had run a subacute or chronic course which was made acute by the action of some stress factors (continuous running, intoxications oligoelement disturbances, etc.). The finding was also characteristic of reactive processes taking place under the action of some specific virus that probably took part in the etiology of the disease and required an intermediary host that remained unknown at the time.
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PMID:[Pathomorphological changes in the organs of cattle dying in so-called sudden death]. 673 Mar 33


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