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Query: UMLS:C0019158 (hepatitis)
 30,205 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The efficacy of paravariceal sclerotherapy for bleeding oesophageal varices was evaluated. Alcoholic and post-hepatitis liver cirrhosis were the main causes of portal hypertension. A total of 28 patients between June 1982 and December 1983 were treated by this method using a flexible endoscope. Bleeding was initially controlled in 90% of patients. However 30% of patients developed recurrent bleeding within 12 months. One year survival of the patients was 70% indicating this treatment has no effect on the long term survival of the underlying disease. The technique is discussed and its complications analysed.
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PMID:Sclerotherapy for bleeding varices. 387 83

Eighteen patients with protal hypertension were studied. Portal hypertension was due to schistosomiasis (N = 9), cirrhosis (N = 7) and congenital hepatic fibrosis (N = 2) diagnosed by surgical biopsy during the decompressive surgery (selective splenorenal shunt). All the patients have had at least one episode of digestive hemorrhage due to rupture of esophageal varices and received blood transfusion before or during surgery. The incidence of post-transfusion hepatitis was 44% (eight cases). The short and medium-term follow-up was good regardless the etiology of portal hypertension. The authors attributed these results mainly to good hepatic function at the time of surgery, younger patient population and good surgical technical conditions.
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PMID:[Selective splenorenal shunt and post-transfusional hepatitis. Short and medium-term follow-up]. 393 82

A patient presented with recurrent upper gastrointestinal bleeding. Celiac and superior mesenteric angiography showed a superior mesenteric venous aneurysm, a normal-sized liver, an enlarged spleen, and esophageal varices. The patient gave no history of hepatitis or alcoholism. It is concluded that the portal hypertension was secondary to aneurysm of the superior mesenteric vein. Aneurysms of the portal venous system can cause chronic portal hypertension due to alteration of blood flow. We believe this to be the second case reported in the English literature of a superior mesenteric venous aneurysm.
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PMID:Superior mesenteric venous aneurysm. 402 79

One hundred twenty-eight records of patients with multiple myeloma were reviewed to assess the incidence and manifestations of liver involvement. Histologic study of the liver was available in 21 patients. Diffuse infiltration of the liver by plasma cells was observed in 10 patients, myeloid metaplasia in four, amyloidosis in two, toxic hepatitis in two, and extrahepatic cholestasis secondary to infiltration of the peripancreatic tissue by plasma cells in one. The clinical signs of plasma cell infiltration of the liver consisted of hepatomegaly in seven patients, mild elevation of liver enzymes in five, and portal hypertension in two. Jaundice was only observed in patients with hepatitis or extrahepatic cholestasis. Liver infiltration by plasma cells did not appear to have a major prognostic significance.
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PMID:Liver involvement in multiple myeloma. 402 19

The majority of infants with cytomegalovirus hepatitis have resolution of the disease with little evidence of fibrosis; there are only rare instances of cirrhosis. We report an infant with cytomegalovirus hepatitis who developed portal hypertension and hematemesis at 3 months of age. Liver biopsy showed resolution of the hepatitis but the presence of noncirrhotic sinusoidal fibrosis. Because of recurrent hematemesis in spite of sclerosing therapy on two occasions, the beta antagonist propranolol was begun. Hepatic wedge pressures before and after treatment with propranolol were 13 and 7 mm Hg, respectively. The findings emphasize: (i) that cytomegalovirus hepatitis may result in noncirrhotic sinusoidal fibrosis and (ii) that propranolol may be beneficial in the management of portal hypertension secondary to noncirrhotic sinusoidal fibrosis.
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PMID:Noncirrhotic portal hypertension in congenital cytomegalovirus infection. 608 85

Clinical, biochemical and histological features of chronic hepatitis type B were studied in 29 children aged 8 months to 13 years. On entry into the study, all were known to have had hepatitis B surface antigen (HBsAg) with elevated serum transaminase levels for at least six months. A possible source of infection was found in 15 children. When they entered the study, all patients were anicteric and all but one asymptomatic. Hepatomegaly was detected in 15 patients and was associated with splenomegaly in two. Hypergammaglobulinemia was present in 4 children. Serological evaluation of hepatitis B virus markers showed evidence of complete viral replication (HBeAg positivity) in 24 cases and incomplete replication (anti-HBeAg positivity) in 5. Liver histology showed chronic persistent hepatitis (CPH) in 18 children, and chronic aggressive hepatitis (CAH) in 10 (3 moderately active and 7 with major signs of aggressivity ) associated with cirrhosis in 5. One patient had only minimal histological changes. Evaluation of clinical, biochemical and virological parameters did not strictly parallel the histological diagnosis in terms of "activity" of the disease. Follow-up for a mean period of 13 months showed good clinical tolerance to the disease in both CPH and CAH patients. Only 2 children with CAH were given corticosteroids and/or azathioprine for a short period. During follow-up no children with active disease developed liver insufficiency or evidence of portal hypertension. No significant difference in the percentage of children who had seroconversion to antiHBe was found between CPH and CAH groups. Only one child with CAH became HBsAg negative.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Chronic HB virus hepatitis in children. A study of 29 cases]. 632 26

Two cases of very probable post-hepatitis cirrhosis are presented. Both were complicated by presinusoidal portal hypertension (P. H. T.), the peroperative portal pressures measured directly being much higher than the wedged hepatic venous pressures. Although post-sinusoidal P. H. T. is the usual complication of most types of cirrhosis, these two cases support recent studies reporting the possibility of pre-sinusoidal P. H. T. in post-hepatitis cirrhosis. The wedged hepatic venous pressure is not a reliable indicator of portal pressure in these cases. The presence of presinusoidal P. H. T. does not exclude the diagnosis of cirrhosis but makes that of alcoholic cirrhosis very unlikely.
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PMID:[Presinusoidal portal hypertension in post-hepatitis cirrhosis]. 641 11

It is currently believed that non-A, non-B hepatitis represents several different viral infections. Although the condition is clearly distinct from common cases of hepatitis A and B, new forms of non-A, non-B hepatitis have recently been found that share some characteristics with these diseases. Reliable serologic assays do not exist, but animal transmission and electron microscopic studies indicate the presence of more than one viral agent. The great risk of chronicity following post-transfusion non-A, non-B hepatitis contrasts with the infrequent chronicity of sporadic non-A, non-B disease. Chronic non-A, non-B hepatitis is usually clinically inapparent with mild biochemical abnormalities; nevertheless, it slowly but relentlessly progresses to cirrhosis and portal hypertension.
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PMID:Non-A, non-B hepatitis: etiology and clinical course. 642 72

The pathology, treatment and progress of 33 children with portal hypertension are reviewed. There were 20 patients with extra-hepatic portal obstruction (EHB) and 13 with intra-hepatic obstruction (IHB). The lesion in all the EHB was a block in the portal vein: in IHB it was a post-hepatitis cirrhosis in two cases and in the others a congenital abnormality. Treatment was surgical in 32 patients. The prognosis in EHB is good and long survival after operation was the rule. In IHB the survival depended upon the type and severity of the hepatic disorder and the incidence of recurrent bleeding. The frequency of recurrent bleeding was found to vary with the operation performed being greatest after splenectomy alone or with devascularisation, and least after lieno-renal anastomosis. The follow-up ranged from one year to more than 28 years.
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PMID:Portal hypertension in children. An experience of 33 cases. 653 77

Porto-azygos disconnection is one of the therapeutic choice of portal hypertension. This technique have been used in a 13 year old boy with bleeding oesophageal varices during the evolution of a cirrhosis caused by active hepatitis. Disconnection was done in emergency using a total ligature of the oesophagus by left thoracotomy upon a clip introduced by oral way. By this technique, the abdomen and the digestive tract keep untouched. One year after the operation no oesophageal varices can be seen at endoscopy and a slight oesophageal stenosis have been easily treated by dilatations.
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PMID:[Azygo-portal disconnection using the thoracic approach in children]. 660 7


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