Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019158 (hepatitis)
 30,205 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Nineteen patients (14 women, 5 men) received external radiation therapy (ERT) between 1980 and 1988 for gall-bladder carcinoma. Eleven patients had complete resection (cholecystectomy in eight cases), six incomplete gross resection and two only percutaneous transhepatic biliary drainage (PTBD). The modalities of ERT were variable and doses ranged from 30 Gy/10 fractions to 50 Gy/25 fractions. Among 11 patients with complete resection (9/11 with T1 or T2 stages), overall survival was 55% at 48 months and 36% at 60 months, median survival was 48 months and at the time of this report 3/11 patients were alive with no evidence of disease, 54, 65, 76 months after surgery, and eight dead of cancer 8-114 months. Local control was achieved in 66 patients with T1 or T2 stages. All eight patients who had palliative surgery or PTBD died of cancer after 4-20 months with median survival of 6 months. Three complications were noted: one gastric ulcer in the course of ERT (surgical treatment), one duodenal ulcer which occurred 6 months after completion of ERT (medical treatment) and one regressive radiation hepatitis. From this experience it appears that ERT in gall-bladder carcinoma is well tolerated, can obtain local control and prolonged survival after complete resection and good palliation in non-resectable tumors.
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PMID:Primary carcinoma of the gall-bladder: potential for external radiation therapy. 753 33

We report here on two patients with kidney allografts who had hepatitis and duodenal ulcer caused by cytomegalovirus. In one case, hepatosplenomegaly and jaundice appeared after high fever lasting for ten days. Laboratory examinations showed liver dysfunction and lymphocytosis with atypical forms. Virological studies revealed cytomegalovirus infection and we successfully treated the patient with human interferon-beta. In the other case, duodenal bleeding followed by interstitial pneumonia occurred at the 54th day after transplantation. Bleeding from the small duodenal ulcer did not stop in spite of conservative and endoscopic therapies, and gastrectomy was performed. Histologically many epithelial cells with intranuclear inclusions were found around the ulcer. Virological studies showed elevation of antibody titres to cytomegalovirus which was isolated from the urine and oropharyngeal secrete. After gastrectomy and treatment with ganciclovir, the general condition improved and graft function was maintained. Our experience with these cases suggests that aggressive diagnostic investigations for cytomegalovirus infection are essential in patients with organ allografts who present liver and gastrointestinal lesions.
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PMID:Cytomegalovirus-associated hepatitis and duodenal ulcer in kidney allograft recipients. 761 76

The incidence of various forms of stomach ulcer, their combination with liver diseases and pathogenetic relationships of these two pathological types have been studied on the material of 6456 autopsy cases for 1983-1992. High incidence of nonspecific reactive hepatitis in both gastric and duodenal ulcer and that of liver cirrhosis and cirrhosis-carcinoma in the pyloro-duodenal ulcer is established. A role of gastrin as a promoter in the development of liver cirrhosis and carcinoma in pyloroduodenal ulcer is suggested. The role of nonspecific reactive hepatitis in chronization of the hepatic pathological process is not excluded.
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PMID:[Peptic ulcer and liver pathology (an analysis of 6456 autopsy observations during 1983-1992)]. 913 91

This is a summary of the research topics, of current interest, relating to digestive disease in Korea. This review is based on the subjects of the papers that were accepted for presentation at the 34th Annual Meeting of the Korean Society of Gastroenterology and the 39th Semiannual Meeting of the Korean Society of Gastrointestinal Endoscopy held November 22-24, 1995, in Seoul. The most popular topics were on Helicobacter pylori infection. These included experimental papers on the pathogenesis of bacteria-associated gastritis and the duodenal ulcer. Recently, the increase in the number of papers published on the motility of the gastrointestinal and pancreaticobiliary tracts is quite remarkable. Molecular genetic works on oncogenesis using cultured tumour cell lines, on the enzyme expression in the biopsied mucosal cells of the small intestine, and on the various expressions of viral genomes in the hepatocytes are among these recent topics of research. Clinical works, such as therapeutic endoscopy in malignant diseases and therapeutic trials in the hepatitis virus-associated chronic liver diseases are also popular topics.
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PMID:Current topics on digestive disease in Korea. 919 93

A total of 92 patients with duodenal ulcer (DU) who took part in the elimination of aftereffects of Chernobyl accident in 1986 were examined. Of these, 46 patients (group I) developed DU against the background of persisting hepatitis. The above patients demonstrated significant increase in the peripheral blood levels of hemoglobin and red cell count as well as immunoglobulins of all classes and circulating immune complexes in blood serum. By far the commonest among group I patients (compared to group II) were such events as allergization of the organism and duodenogastric reflux. Based on the studies made a conclusion is drawn to the effect that it is necessary that specific agents capable of improving hemodynamics, endowed with immunocorrective and antiallergic activity should be included into a complex of therapeutic measures designed to treat those patients with hepatitis having been exposed to ionizing radiation, together with those means capable of normalizing the pyloroduodenal portion motor-and-evacuatory function to prevent the DU development.
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PMID:[The mechanisms of ulcerogenesis in liver pathology in persons exposed to the action of ionizing radiation]. 947 70

Antibodies (Abs) hydrolyzing proteins, DNA, and RNA are detected in the blood of patients with various autoimmune diseases. In the present work, homogeneous preparations of IgG Abs from the blood of the healthy donors as well as patients with A, B, C, and delta types of viral hepatitis, influenza, pneumonia, tuberculosis, tonsillitis, duodenal ulcer, and some types of cancer were purified. For the first time, the fraction of IgG and its Fab fragments of patients with viral hepatitis were shown to have high DNA- and RNA-hydrolyzing activity. In case of Abs from the healthy donors and patients with other diseases, high activity of Abs was not detected. The data obtained by various methods indicate that the activity of hepatitis Abs is an intrinsic property of the immunoglobulins. The relative rates of hydrolysis of cCMP, poly(U), poly(A), poly(C), and tRNA(Phe) by hepatitis Abs were compared with those of RNase A and other RNases from human blood. Significant differences in activities of Abs and nucleases in hydrolysis of model substrates were demonstrated. Thus, catalytically active Abs can appear in the blood of patients not only with autoimmune disorders, but with viral diseases as well.
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PMID:DNA- and RNA-hydrolyzing antibodies from the blood of patients with various forms of viral hepatitis. 948 69

Oxidative stress appears to play a role in the pathogenesis of a number of gastrointestinal disease states, including pancreatitis; gastric and duodenal ulcer disease; IBD; gastric, esophageal, and colon cancers; and hepatic injury secondary to alcohol, metal storage disorders, hepatitis, and ischemia/reperfusion injury. The nutritional antioxidants are attractive potential therapeutic and chemopreventive agents because they are inexpensive and have a relatively low toxicity profile. A word of caution should be noted: Some antioxidants, such as vitamin C, can be prooxidant under certain conditions, and systemically altering the redox state may have untoward effects on the inflammatory response in certain disease states. Thus, at the current time, antioxidant therapy should be restricted to randomized, controlled clinical trials, in which treatment effects can be closely monitored, and therapeutic efficacy can be determined with scientific accuracy.
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PMID:Nutrient antioxidants in gastrointestinal diseases. 965 24

To assess the reliability of data on medical conditions, and menstrual or reproductive history, a sample of 294 controls interviewed in hospital between 1989 and 1992 for an Italian case-control study on digestive tract neoplasms was re-interviewed at home during 1993. A high agreement between responses at the two interviews (kappa > or = 0.85) was observed for most medical conditions, including diabetes, cholelithiasis, hepatitis, duodenal ulcer, and, among female conditions, uterine fibromas, benign breast disease, hysterectomy and monolateral ovariectomy. For gastric ulcer and parotitis the reliability was less satisfactory (kappa = 0.35 and 0.20, respectively). The agreement was high (kappa > 0.80) also for age at menarche, menopausal status, type and age at menopause, number of children, age at first pregnancy, age at first and last birth, and spontaneous abortions. The agreement was lower for questions on menstrual pattern (kappa = 0.68) and induced abortions (kappa = 0.62). Thus, this study indicates that information on personal medical conditions, and menstrual or reproductive history, provided by hospital controls through an interviewer-administered questionnaire is satisfactory for the purposes of epidemiological inference, and that the interview setting does not substantially influence the recall of this information.
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PMID:Reliability of data on medical conditions, menstrual and reproductive history provided by hospital controls. 1152 Jun 49

The GI endoscopy can be divided into upper GI tract endoscopy (esophago-, gastro-, entero-, fistulo- and cholangioscopy) and lower GI tract endoscopy (recto-, sigmoido-, colonoscopy) from practical point of view and the characteristic of used equipment. A lot of therapeutic methods for GI tract is associated with each of these procedures. GI tract endoscopy doesn't play significant part in diagnosis of acute and chronic C hepatitis. Significance of endoscopy procedures decidedly increases in the case of progressive liver fibrosis and liver cirrhosis associated with HCV infection., where changes in GI tract are observed to 87% patients. These changes can be divided into: 1) not associated with portal hypertension, 2) these ones caused by portal hypertension. The most observed changes not associated with portal hypertension involve: reflux esophagitis, esophageal candidiasis; different variants of gastritis, gastric and duodenal ulcer. To the changes connected with portal hypertension, which are possible for endoscopy assessment, belongs esophageal and gastric varices, portal gastro-, entero-, colopathy, and gastric antral vascular ectasiae (GAVE). However to-day endoscopy has got not only diagnostic significance but also enables: estimation of pharmacotherapy efficiency, the primary and secondary prophylaxis of bleedings from GI varices as well as therapy of GI bleeding in this group of patients.
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PMID:[Endoscopy in the diagnosis of chronic hepatitis C--diagnosis and therapy depending on the phase of diseases progression and liver regeneration]. 1555 69

A 30-year-old man consulted a local hospital because of upper abdominal pain and tarry stool and was admitted because of duodenal ulcer and hepatic dysfunction. On the fifth hospital day, he developed fever and erythema on the upper body. Liver biopsy demonstrated giant cell hepatitis, and interferon alpha was therefore administered. Liver function improved, though total bilirubin increased to 22.3 mg/dl. The eruption and fever improved in the 3rd hospital week, deteriorated again in the 5th hospital week, and then improved again in the 8th hospital week. Thereafter, he was transferred to our hospital for detailed examination of atypical lymphocytosis, lymphopenia, and hypogammaglobulinemia. Many lymph nodes measuring about 1 cm were detected by palpation. After admission to our hospital, lymphoadenopathy and fever improved. We measured the level of HHV-6 antibody since the clinical course was similar to that of drug-induced hypersensitivity syndrome (DIHS). HHV-6 IgG was x2,560, although it had been x160 at the previous hospital. The clinical course appeared similar to that of DIHS, but drugs known to cause DIHS had not been administered.
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PMID:[Hypogammaglobulinemia with a clinical course similar to that of drug-induced hypersensitivity syndrome]. 1922 25


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