Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019158 (hepatitis)
 30,205 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Quadratic multiple discriminant analysis of 25 commonly ordered laboratory tests resulted in correct classification of 100% of nonalcoholics without overt liver disease, 98% of alcoholism treatment program patients with presumed mild liver involvement, 96% of alcoholics with liver disease, and 89% of nonalcoholics with liver disease. Direct comparison of the biopsy-verified alcoholic and nonalcoholic liver disease groups resulted in 100% discrimination, and removal of traditionally evaluated liver tests from the battery of 25 tests did not substantially alter the original classification accuracy. Alcoholic and nonalcoholic liver disease was still 100% differentiable when equated for number of patients with cirrhosis, hepatitis, and hepatitis combined with cirrhosis or fibrosis. Additional utility of the quadratic discriminant approach was demonstrated when 83% alcoholic and 83% nonalcoholic liver disease cases were diagnosed correctly in a prospective manner. In contrast, use of aspartate aminotransferase to alanine aminotransferase ratios (ie, SGOT to SGPT) identified correctly 75% and 33% of patients, respectively.
JAMA 1982 Nov 12
PMID:Biochemical and hematologic correlates of alcoholism and liver disease. 713 77

A 29-year-old man with quiescent multiple sclerosis had hemiparesis during the prodrome of serologically confirmed type A hepatitis. After neurological symptoms and acute hepatitis had abated, hemiparesis again developed when skin tests were applied. While he was receiving prednisone, skin test inflammation and neurological signs cleared. One year later, lymphocyte stimulation, which had been noticeably elevated during his exacerbations, returned to low normal. Both hepatitis A and skin test antigens produced immunostimulation that resulted in exacerbation of multiple sclerosis.
JAMA 1980 Nov 21
PMID:Immunologic mechanisms in multiple sclerosis. Exacerbation by type A hepatitis and skin test antigens. 743 54

A 3 1/4-year study assessed intervention approaches for hemodialysis-associated hepatitis. A 12-month retrospective study was followed by one year of prospective surveillance (during which attention to hygienic techniques was encouraged) and then by a 15-month period during which antigen-positive cases were transferred from study centers to an isolation hemodialysis center (IHL). The incidence of hepatitis B infection (HBI) fell 35.9% in study centers during surveillance; this was followed by a 50.0% drop during the IHC phase. The total 67.9% drop during the entire study period was statistically highly significant; the IHC contributed significantly more to the total drop than did surveillance alone. At comparison units, HBI increased 97.9% during the same period. This study indicates that HBI incidence can be markedly reduced by a combination of surveillance and assignment of antigen-positive patients to a separate dialysis unit.
JAMA 1981 Jan 09
PMID:Control of hepatitis B infection. The role of surveillance and an isolation hemodialysis center. 745 30

Unconventional medical practices, including the use of herbal remedies, are prevalent in the United States. Chaparral is an herbal preparation made from a desert shrub and used for its antioxidant properties. We report the case of a 60-year-old woman who took chaparral for 10 months and developed severe hepatitis for which no other cause could be found. Despite aggressive supportive therapy, the patient deteriorated and required orthotopic liver transplantation. She is now well, more than 1 year after her transplant. This case suggests that chaparral can cause serious liver injury and fulminant hepatic failure. Herbal medications should be considered as potential causes of liver toxicity.
JAMA 1995 Feb 08
PMID:Chaparral ingestion. The broadening spectrum of liver injury caused by herbal medications. 783 70

There is evidence that transmission of serum hepatitis is associated with transmission of virus-like particles, approximately, 20 millimicron in diameter, containing the Australia or serum hepatitis (SH) antigen, which is currently referred to as the hepatitis associated antigen (HAA). Virus-like particles containing HAA were in the following materials, inoculation of which produced serum hepatitis: (1) a pool of human plasma, (2) serum obtained during the acute phase of hepatitis from a recipient of the plasma pool, (3) a preparation of human thrombin, and (4) serum from a proved hepatitis carrier. The HAA appeared in the serum samples of 61 individuals inoculated with these materials; serum hepatitis developed in 38 of them. Inoculation of dilutions of the plasma pool showed that serum hepatitis can be transmitted by materials containing HAA in amounts too low to be detected by current techniques.
JAMA 1996 Sep 11
PMID:Transmission of serum hepatitis. 1970. 876 98

The largest lymphoid organ in the body is the gut and the gut-associated lymphoid tissue. The mucosal immune system faces many challenges in protecting the body from microbial invasion. Its chief function is to maintain a diverse population of mature lymphocytes capable of responding to foreign antigens. This task is accomplished with a variety of unique features that distinguish the mucosal from the systemic immune system. In addition, the mucosal immune system plays a role in inflammatory bowel disease, Whipple disease, autoimmune gastritis, Helicobacter pylori infection, immunoproliferative small intestinal disease, hepatitis A, B, C, D, E, F, and G, autoimmune hepatitis, primary biliary cirrhosis, progressive sclerosing cholangitis, and vanishing bile duct syndrome.
JAMA 1997 Dec 10
PMID:Immunopathogenesis of gastrointestinal and hepatobiliary diseases. 939 57

Treatment of hemorrhagic diathesis after saline-solution-induced abortion is discussed. A 23-year-old woman who had a therapeutic abortion by intraamniotic instillation of 23% saline solution developed uterine bleeding 2 hours after the fetus had passed. Her fibrinogen level was 125 mg% (normal 250-450 mg%) and her partial thromboplastin time was 97 seconds (normal 45 seconds). 2 units of fibrinogen, followed by immune serum globulin, were administered to the patient. Approximately 2 1/2 months later the patient developed hepatitis. The question of whether or not this was proper treatment for her low fibrinogen state was asked. The consultant (author) stated that the fibrinogen could have been kept in reserve for the unlikely emergency of increasing fibrinogenopenia or hemorrhage. The addition of the fibrinogen substrate could (rarely) exacerbate disseminated intravascular coagulation as well as inoculate the patient with hepatitis virus. In a patient such as this, usually needs are met with transient obstetric and medical support since body processes restore the depleted hemostatic and fibrinolytic mechanisms.
JAMA 1972 Jun 26
PMID:Treatment of hemorrhagic diathesis after saline-solution-induced abortion. 1230 85

Faced with explosive growth in its prison population and a legal mandate to improve medical care for incarcerated offenders, the state of Texas implemented a novel correctional managed health care program in 1994. The organizational structure of the program is based on a series of contractual relationships between the state prison system, 2 of the state's academic medical centers, and a separate governing body composed of 9 appointed members, which include 5 physicians. All medical, dental, and psychiatric care for more than 145,000 offenders, incarcerated under the jurisdiction of the Texas Department of Criminal Justice, is provided by the University of Texas Medical Branch and Texas Tech University Health Sciences Center. The health delivery system is composed of several levels of care, including primary ambulatory care clinics in each prison unit, 16 infirmaries at strategic locations throughout the state, several regional medical facilities, and a dedicated prison hospital with a full range of services. Specialized treatment programs have been established at various units for patients with chronic conditions, such as hypertension, diabetes mellitus, major psychiatric disorders, hepatitis, and human immunodeficiency virus infection. Significant improvements in health outcomes have occurred since the managed care program was established.
JAMA 2004 Jul 28
PMID:Health care delivery in the Texas prison system: the role of academic medicine. 1553 4


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