Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0019087 (hemorrhagic diathesis)
 678 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The principal advantages of suprapubic drainage of the bladder compared with the transurethral indwelling catheter are to be seen in holding back ascending infection of the urinary tract and avoidance of urethral trauma. In addition to relieving the bladder in subvesical obstructions the most important indication in practise is continuous drainage of urine in patients in intensive care. With strict observation of puncture technique and contraindications (contracted bladder, tumors in the lower abdomen, bladder carcinoma, macrohematuria and hemorrhagic diathesis) the entire complication rate is 4.3% (2.3% macrohematuria, 1.5% local infection, 0.5% peritoneal lesion). With the introduction of the disposable puncture systems the suprapubic bladder fistula has become a superior alternative to the indwelling catheter in many cases.
MMW Munch Med Wochenschr 1979 Dec 07
PMID:[Suprapubic drainage of the bladder (author's transl)]. 11 66

The clinical and laboratory features of nine patients with chronic myelomonocytic leukemia are described. Hepatic or splenic enlargement accompanied by an absolute monocytosis in an older patient with an elevated serum or urine lysozyme and serum vitamin B12 levels were characteristic of the majority of patients in this series. No single clinical or laboratory finding was diagnostic for the disease. Most importantly, seven of nine patients had abnormal coagulation values; in two cases the abnormalities were consistent with disseminated intravascular coagulation and correlated with a hemorrhagic diathesis. It is concluded that patients with chronic myelomonocytic leukemia who have thrombocytopenia or a bleeding tendency should be evaluated for evidence of disseminated intravascular coagulation.
Cancer 1979 Dec
PMID:Disseminated coagulopathy in chronic myelomonocytic leukemia. 29 10

A case of spontaneous hematomyelia was reported with a review of the literature. A 39-year-old woman, with sudden onset of pain in her left neck and arm 13 days previously, presented with a progressive flaccid tetraplegia below C5, dissociated sensory loss from C7 through Th4 dermatome and a minimal deep sensory loss in her right leg. Myelography revealed a symmetrical enlargement of the spinal cord at the leve of C5, C6 and C7. Laminectomy was performed and intramedullary blood clot, which was located in the region of C6 and C7, was evacuated. However, there were no vascular anomalies not only in macroscopic findings but also in histological examination. The postoperative course was uneventful and the patient gradually improved in her motility. At 5 month' follow-up examination she continued to do well with a minimal sensory loss of all modalities below the level of C7. Report of 16 patients with spontaneous hematomyelia including our case have been reviewed. Incidence of spontaneous hematomyelia without vascular anomalies or hemorrhagic diathesis very rare, being found in only 4 cases. In cases with good outcome the intramedullary hematoma was found to be located below the lower cervical region and limited within 2 spinal segments in its extent. Good postoperative results were obtained in 5 out of 7 patients who received surgical intervention, suggesting an essential importance of early diagnosis and surgery.
No Shinkei Geka 1979 Dec
PMID:[A case of spontaneous hematomyelia (author's transl)]. 53 Mar 69

Owren's disease is a rare hemorrhagic diathesis which can occur in infancy as a severe hemorrhagic disorder. It also appears in adult life when clinical manifestations are those of acquired deficiencies of other coagulation factors. A familial survey enables a definite diagnosis to be made as it demonstrates the presence of deficiency in factor V in one or several members of the family. Such a case is reported in a young adult with an associated intestinal malabsorption syndrome due to lambliasis. After administration of vitamin K the deficiency in factor V remained an isolated disorder, and the hemostatic anomaly was found in three other members of the family. The deficiency was a partial one, which explains why the Owren's disease only became evident during the course of the malabsorption syndrome due to lambliasis which caused a reduction in the level of vitamin K dependent factors II, VII, and X.
Ann Med Interne (Paris) 1979 Dec
PMID:[Partial congenital deficiency in factor V associated with an intestinal malabsorption syndrome due to lambliasis. A familial survey (author's transl)]. 53 80

A followup study of a sample of 160 of the 2500 men, who had vasectomies at the R.G. Kar Medical College and Hospital in Calcutta from 1972-1975, was conducted in order to assess the characteristics of acceptors, the frequency of postoperative complications, and the impact of vasectomy on sexual feelings. 53.1% of the men were between the ages of 35-44. Average marriage duration was 13.1 years and the men had an average of 3.75 children. 96.8% of the men were literate. 60.6% had incomes below Rs.200, 35.6% had incomes between Rs.201-500, and 3.8% had incomes above Rs.501. 159 of the men were Hindu. 50% of the men reported that they experience contraceptive failure prior to vasectomy. Post operative complications were experienced by 70.62% of the men. 32.5% of the 160 men experienced early complications within 10 days after the operation and 83.1% experienced late complications, 10 or more days following the procedure. In reference to early complications, out of the total 160 patients, 11.2% had local pain or swelling; 14.4% had stitch abscess, 4.4% had bleeding or hematoma, 1.9% had fever, and 0.6% had hemorrhagic diathesis. In reference to late complications, out of the total 160 patients, 13.1% had cord related problems, 10.6% had swelling of the epididymis, 10.6% had swelling of the testis, and 3.8% experienced a general deterioration in health. Sexual feelings after the vasectomy remained the same for 62.5% of the patients, decreased for 31.25%, and improved for 6.25%. Among those patients who had decreased sexual feeling, 55.6% were between the ages of 45-54, 31.8% were between the ages of 35-40, and 25.5% were between the ages of 25-34. A decrease in sexual feeling was significantly related to post operative late complications. Among the 123 men who had a semen analysis 90 days following vasectomy, 18 had positive readings and 105 had negative readings. 6 of the 123 men reported that their wives conceived after vasectomy and of these 6, only 4 had positive readings. The study findings were presented in tabular form.
J Indian Med Assoc 1979 Dec 16
PMID:A study on postoperative vasectomy cases. 54 87

Coagulation factor XIII (fibrin stabilizing factor, FSF) is detectable in plasma, platelets, placenta and various tissues. In the activated form FSF has the enzymatic properties of a transglutaminase and is capable of stabilizing fibrin by inducing covalent bondings between fibrin monomers. In patients with congenital factor XIII deficiency or acquired immune inhibitors of fibrin stabilization a severe bleeding tendency is evident. There is not yet enough information available concerning the significance of reduced FSF-activity as cofactor in hemorrhagic diathesis and wound healing disturbances in various disease states. There are some indications from experimental studies that there might be an influence of FSF on tumor growth and metastasis as well as arteriosclerosis. The quantitation of the enzyme by radiological and immunological techniques yield reproducible results. Fibrin in its stabilized or non stabilized form can be discriminated in polyacrylamide gel electrophoresis after reduction of fibrin clots.
Klin Wochenschr 1975 Dec 15
PMID:[Blood coagulation factor XIII and fibrin stabilization (author's transl)]. 76 11

There is a description of the finding in whole-body irradiated young cattle exposed to 60Co in the doses of 3.7 and 2.0 J kg-1 (370 and 200 rad). The principal picture is a hemorrhagic diathesis localized above all in the permanently mechanically active organs and parts of the skeletal muscles. The degree of the regeneration of lymphoid tissue was dependent on the length of survival and on the amount of absorbed dose.
Vet Med (Praha) 1975 Dec
PMID:[Pathomorphological findings in irradiated cattle]. 81 80

Following a period of prolonged severe vomiting, an intramural esophageal hematoma could be demonstrated by endoscopy and by X-ray in a 21 year old patient with hepatic and renal failure after exposure to carbon tetrachloride. The hematoma resolved spontaneously. The intramural hematoma is thought to have developed from a microdissection of the esophageal wall in the presence of a hemorrhagic diathesis.
Clin Nephrol 1976 Dec
PMID:Intramural hematoma of the esophagus: a complication of carbon tetrachloride intoxication with acute renal failure. 108 96

Coagulation Factor V is an essential component of the prothrombinase complex, which activates the zymogen prothrombin to thrombin. A patient was described who developed a Factor V inhibitor that neutralized the procoagulant activity of Factor V and resulted in a fatal hemorrhagic diathesis (Coots, M. C., A. F. Muhleman, and H. I. Glueck. 1978. Am. J. Hematol. 4:193-206). This inhibitor was shown to be an IgG antibody that bound to the light chain of Factor V. Using a series of light chain deletion mutants, we have found that this antibody binds to the second C-type domain of the light chain. Both inhibitor IgG and Fab fragments rapidly neutralized the procoagulant activity of Factor Va, implying that the neutralization resulted from specific binding to the C2 domain. We have previously demonstrated that deletion of the C2 domain results in loss of procoagulant activity, as well as loss of phosphatidylserine-specific binding. Confirming these results, both inhibitor IgG and Fab fragments interfered with phosphatidylserine-specific binding of Factor V. Conversely, preincubation of Factor Va with procoagulant phospholipids protected the cofactor from inactivation by the inhibitor. Our results suggest that this inhibitor neutralizes the procoagulant activity of Factor Va by interfering with the C2-mediated interaction with phospholipid surfaces, thereby disrupting formation of the prothrombinase complex.
J Clin Invest 1992 Dec
PMID:Characterization of an acquired inhibitor to coagulation factor V. Antibody binding to the second C-type domain of factor V inhibits the binding of factor V to phosphatidylserine and neutralizes procoagulant activity. 128 31

This study characterizes a congenital hemorrhagic disorder caused by a platelet function defect with the following features: (1) severely impaired platelet aggregation and fibrinogen or von Willebrand factor (vWF) binding induced by adenosine diphosphate (ADP); (2) defective aggregation, release reaction, and fibrinogen or vWF binding induced by other agonists; (3) normal aggregation and release reaction induced by high concentrations of thrombin or collagen; (4) no further inhibition by ADP scavengers of aggregation, release reaction, and fibrinogen or vWF binding, comparable with those observed for normal platelets in the presence of ADP scavengers; (5) normal membrane glycoprotein (GP) composition and normal binding of the anti-GP IIb/IIIa monoclonal antibody 10E5; (6) no acceleration by ADP of binding of the anti-GP IIb/IIIa monoclonal antibody 7E3; (7) normal platelet-fibrin clot retraction if induced by thrombin or reptilase plus epinephrine, absent if induced by reptilase plus ADP; (8) no inhibition by ADP of the prostaglandin E1-induced increase in platelet cyclic adenosine monophosphate, but normal inhibition by epinephrine; (9) defective mobilization of cytoplasmic Ca2+ by ADP; (10) normal binding of 14C-ADP to fresh platelets, but defective binding of [2-3H]-ADP to formalin-fixed platelets. This congenital platelet function defect is characterized by selective impairment of platelet responses to ADP, caused by either decreased number of platelet ADP receptors or abnormalities of the signal-transduction pathway of platelet activation by ADP.
Blood 1992 Dec 01
PMID:Identification of a new congenital defect of platelet function characterized by severe impairment of platelet responses to adenosine diphosphate. 133 2


1 2 3 4 Next >>