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Query: UMLS:C0019087 (hemorrhagic diathesis)
 678 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Scurvy, a disease rarely seen in modern times, results from dietary deficiency of vitamin C and is characterized in adults by hemorrhagic diathesis, hair follicle abnormalities, and osteopenia. We present a 59-year-old man with perifollicular petechiae of the extremities, a painful lower extremity hematoma, and sacral osteopenia, who was repeatedly misdiagnosed with leukocytoclastic vasculitis. The patient's dietary history revealed several months of virtually no vitamin C intake. The patient rapidly improved with vitamin C replacement. We review the biochemical basis and pathophysiology of scurvy, clinical scenarios in which it occurs, clinical signs and radiologic features of the condition, and recommendations for its diagnosis and treatment.
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PMID:Scurvy masquerading as leukocytoclastic vasculitis: a case report and review of the literature. 1631 63

In the experiments reported in the present communication it was found that vitamin C, both natural and synthetic preparations, had no effect on the course of experimental poliomyelitis induced by nasal instillation of the virus. The objection cannot be raised that too large an amount of virus was used, since recent studies (3) on the fate of the nasally instilled virus indicated that all but an undetectable amount of it is swallowed and disappears from the nasal mucosa within 3 hours or less, and that none is demonstrable in the central nervous system before the 3rd day. Vitamin C administration was begun immediately after the instillation of virus and if it were capable of exerting any effect on the virus or the tissues it could have done so even before multiplication of virus had begun. Monkeys whose store of vitamin C was depleted reacted in the same way as those receiving an adequate diet. There is no apparent explanation for the difference between these results and those reported earlier by Jungeblut (1,2). During the present investigation it was found that monkeys on a scorbutic diet died of spontaneous acute infections, chiefly pneumonia and enterocolitis, while their mates receiving an adequate diet remained well. The surviving monkeys on the scorbutic diet developed the osseous and other changes of human scurvy, and the vitamin C used in this study was shown to produce healing and calcification in the bones as well as to check the edema and hemorrhagic diathesis.
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PMID:VITAMIN C IN RELATION TO EXPERIMENTAL POLIOMYELITIS : WITH INCIDENTAL OBSERVATIONS ON CERTAIN MANIFESTATIONS IN MACACUS RHESUS MONKEYS ON A SCORBUTIC DIET. 1987 Aug 60

Pediatric scurvy is a rare condition characterized by perifollicular petechiae and bruising, hemorrhagic gingivitis and musculoskeletal symptoms, all assumed to be predominantly related to abnormal collagen structure. We report on a 9-year-old autistic boy with vitamin C deficiency due to a highly limited food range presenting with multiple petechiae, gum bleeding and debilitating bone pain, in whom platelet aggregometry revealed a distinctly reduced thrombocyte aggregation, normalizing after vitamin C supplementation. This observation indicates that platelet dysfunction may additionally contribute to the hemorrhagic diathesis in scurvy, and demonstrates that ascorbic acid deficiency should be considered in children with an otherwise unexplained acquired thrombocytopathy.
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PMID:Reduced platelet aggregation in a boy with scurvy. 2307 Aug 64