Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0019087 (hemorrhagic diathesis)
 678 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A followup study of a sample of 160 of the 2500 men, who had vasectomies at the R.G. Kar Medical College and Hospital in Calcutta from 1972-1975, was conducted in order to assess the characteristics of acceptors, the frequency of postoperative complications, and the impact of vasectomy on sexual feelings. 53.1% of the men were between the ages of 35-44. Average marriage duration was 13.1 years and the men had an average of 3.75 children. 96.8% of the men were literate. 60.6% had incomes below Rs.200, 35.6% had incomes between Rs.201-500, and 3.8% had incomes above Rs.501. 159 of the men were Hindu. 50% of the men reported that they experience contraceptive failure prior to vasectomy. Post operative complications were experienced by 70.62% of the men. 32.5% of the 160 men experienced early complications within 10 days after the operation and 83.1% experienced late complications, 10 or more days following the procedure. In reference to early complications, out of the total 160 patients, 11.2% had local pain or swelling; 14.4% had stitch abscess, 4.4% had bleeding or hematoma, 1.9% had fever, and 0.6% had hemorrhagic diathesis. In reference to late complications, out of the total 160 patients, 13.1% had cord related problems, 10.6% had swelling of the epididymis, 10.6% had swelling of the testis, and 3.8% experienced a general deterioration in health. Sexual feelings after the vasectomy remained the same for 62.5% of the patients, decreased for 31.25%, and improved for 6.25%. Among those patients who had decreased sexual feeling, 55.6% were between the ages of 45-54, 31.8% were between the ages of 35-40, and 25.5% were between the ages of 25-34. A decrease in sexual feeling was significantly related to post operative late complications. Among the 123 men who had a semen analysis 90 days following vasectomy, 18 had positive readings and 105 had negative readings. 6 of the 123 men reported that their wives conceived after vasectomy and of these 6, only 4 had positive readings. The study findings were presented in tabular form.
 ...
PMID:A study on postoperative vasectomy cases. 54 87

An outbreak of chronic liver disease was investigated in a kennel of dogs. Anorexia, depression, polyuria, polydipsia, icterus and a terminal hemorrhagic diathesis were noted in clinically affected dogs. Thrombocytopenia, hypofibrinogenemia, elevated fibrinogen degradation products and prolonged activated partial thrombosplastin times (PTT) and one-stage prothrombin times (PT) were associated with the hemorrhagic crisis. Aflatoxicosis was confirmed by the presence of significant levels of aflatoxicosis was confirmed by the presence of significant levels of aflatoxin B in the commercial dog food being fed. A subacute hepatitis was found on necropsy. Disseminated intravascular coagulation was suspected as the cause of the hemorrhage in these cases and treatment was instituted.
 ...
PMID:Disseminated intravascular coagulation complicating aflatoxicosis in dogs. 55 87

The spectrum of progestin therapy has changed and expanded during the last few years. 1. The drug-therapy of choice in endometriosis is the medication of progestins for at least six months, for instance ethinyl-testosterone. If a patient wants additional children the "more gentle" dydrogesterone should be considered. 2. In the treatment of dysmenorrhea combination pills should be given, sequentials should be avoided. In the case of incompatibility of estrogens or in danger of oversuppression syndrome dydrogesterone should be applicated. 3. Dysfunctional bleedings should lead to an intense search for their cause. The treatment consists in an estrogen-progestin combination for 9 days and in cyclic continuation of this therapy for at least a further three months. In the case of hemorrhagic diathesis progestin treatment should be continued. 4. Cyclic adequate progestins have proofed to be successful in handling of hirsutism. The choice of the preparation depends on the patient's wish for children. 5. The progestin test is still the first step in diagnosis of amenorrhea. 6. Progestin therapy is indicated in progressive endometrial carcinoma. Some medical centres treat carcinoma of the mamma successfully with progestins. 7. Nowadays fast and early hormonal pregnancy tests are available. The progestin-pregnancy-test is limited to cases of premenopause. 8. The so-called short luteum phase has received considerable attention as a possible cause of infertility. In these cases a substitutional therapy of progestins should follow. Clomiphene or HCG-therapy is advisable. In short luteum phase and premenstrual spottings potent progestins should be given. 9. High dosage of progestins are in common use in the treatment of abortus imminens. 10. Combination pills and sequentials are widely used, the possible methods of a pure progestin contraception are: minipills, three-month-injections, implanted silastic capsules with progestional compounds, progestin impregnated intrauterine devices, vaginal silastic rings impregnated with progestional compounds. 11. Carcinogenesis of progestins was not detectable. 12. Some progestins are teratogenic.
 ...
PMID:[Current status of gestagen administration. 2. Gestagen therapy in the area of reproduction]. 55 11

Childhood ITP is an acquired hemorrhagic disorder with a heterogeneous clinical course. We measured PAIgG levels in 20 children with ITP (7 acute, 13 chronic). Both groups had significantly greater PAIgG values than age-matched normal subjects and thrombocytopenic controls (P less than 0.001). In addition, PAIgG values in chronic ITP were significantly lower than those in acute ITP (P less than 0.003). Serial PAIgG values were obtained in some patients; most returned to normal in association with clinical recovery. The measurement of PAIgG is useful in the diagnosis and follow-up of childhood ITP. PAIgG values may assist in differentiating acute and chronic disease in children.
 ...
PMID:Platelet-associated immunoglobulin G in childhood idiopathic thrombocytopenic purpura. 57 Feb 18

Dapsone was given for six days to a dog with chronic skin disease. The dog then became weak and anorectic, and it vomited and had purpura caused by severe thrombocytopenic hemorrhagic diathesis. Despite treatment, the dog died a week later. There were clinical and pathologic evidence that the dog's platelets and megakaryocytes had been destroyed during the first few days of dapsone therapy. It was concluded that the syndrome was dapsone-induced and that thrombocytopenia should be considered among the adverse reactions to dapsone in the dog.
 ...
PMID:Fatal thrombocytopenic hemorrhagic diathesis associated with dapsone administration to a dog. 57 35

Two cases of microangiopathic hemolytic anemia in disseminated carcinoma are reported. Both showed the classical features of this illness, namely acute generalized hemorrhagic diathesis, severe hemolytic anemia, thrombocytopenia, fragmentation of erythrocytes in the peripheral blood smear, increased erythropoiesis and megakaryopoiesis or tumor cell invasion in the bone marrow, tumor cell emboli in venules and disseminated intravascular coagulation. In both cases the microangiopathic hemolytic anemia was the first sign of the disseminated carcinoma. Differential diagnosis, pathogenesis and therapy are discussed.
 ...
PMID:[Microangiopathic hemolytic anemia in malignant tumors. 2 cases]. 62 35

The authors examine the main clinical, cytologic and nosographic aspects of conditions and syndromes associated with SBH on the basis of the literature data (about 40 cases) and 23 personal ones. It is necessary to distinguish between three nosological conditions of SBH: hereditary disease, hereditary asymptomatic, acquired per se asymptomatic. From the clinical viewpoint less a half of all SBH cases are hereditary and present a syndrome based on splenomegaly, periodic hemorrhagic diathesis (due to variable thrombocytopenia), not rarely associated with hepatomegaly and lung or nervous system changes (often eyes are involved). There is also a second SBH hereditary form, vary rare and clinically different from the former, determined by deficiency of plasma-lecitin-cholesterol acyltransferase. The peculiar features of SBH are discussed by means of optical, cytochemical, electron microscopical investigations which point out the polymorphous aspect of these "famished" macrophages. The material stored by SBH is heterogeneous and the enzymatic defect of the most frequent form still remains obscure. The presence of SBH in different haemopathies has an analogous significance as Gaucher's cells found outside Gaucher's disease. It is impossible today to deny the existence of two well-identified SBHS.
 ...
PMID:Sea blue histiocytosis. A clinical cytologic and nosographic study on 23 cases. 62 90

Haemorrhagic diathesis was a leading symptom in diagnosing celiac disease in 4 patients. In all 4 patients, a duodenal biopsy showed total villous atrophy. Although 3 of the children were typically dystrophic, the weight of the 4th child, an 8 month old boy, was within the normal range. In this patient, who suffered from neither diarrhea nor vomiting, heavy cutaneous and mucous membrane bleeding were the only symptoms of the disease. In all 4 cases the haemorrhagic diathesis could be explained by a low prothrombin complex, whereas the rest of the coagulation tests were normal. After the administration of Vitamin K1 there was an immediate rise in the prothrombin complex and bleeding was quickly stopped. Noteworthy is that due to infections, 3 of the 4 patients, received antibiotics just before the onset of the bleeding. In celiac disease, the conversion from a K-hypovitaminosis into a K-avitaminosis by the administration of antibiotics is discussed.
 ...
PMID:[Vitamin K deficiency bleeding as a leading symptom in celiac disease (author's transl)]. 64 95

The structure and functions of platelets from a patient in whom albinism and hemorrhagic diathesis were associated have been investigated. Electron microscope studies showed a large reduction in the number of dense bodies and this was confirmed by an examination of fluorescent platelets loaded with mepacrine. The rare dense bodies were much bigger than normally observed; their density was diminished and was localized in a peripheral ring. Other platelet constituents were found to be normal. Platelet peroxidase activity was normal in the canaliculi of the dense tubular system; catalase-positive granules were also present. Serotonin uptake by the patient's platelets was much decreased and reserpine, a potent inhibitor of serotonin accumulation by normal human platelets, did not further decrease this incorporation. The uptake of free 14 C-arachidonic acid by the platelets was greatly diminished, as was its thrombin-induced liberation from phosphatidyl-choline and phosphatidyl inositol. Moreover, platelet phospholipase A1 activity was much reduced and phospholipase A2 activity was undetectable.
 ...
PMID:Studies on a new variant of the Hermansky-Pudlak syndrome: qualitative, ultrastructural, and functional abnormalities of the platelet-dense bodies associated with a phospholipase A defect. 71 98

Whole-body X-ray treatment was experimentally applied (380 median-line dosage) to eight Merino mutton sheep aged approximately one year. Five of the test animals were lost between 16 and 25 days after irradiation. A great diversity of pathomorphological changes was recorded from organs and tissues, and the most important pathological processes which occurred concomitantly with acute to subacute radiation syndrome of sheep were defective haematopoiesis, septico-toxic processes, haemorrhagic diathesis, and partial epilation. Severe damage to the organs involved in haematopoiesis was one of the primary pathological processes and reflected mainly in lymphopenia, agranulocytosis, and thrombocytopenia, in other words, with lymphopoieses, granulopoiesis, and thrombocytopoiesis particularly involved. Insufficiency of cellular (and humoral) defence would obviously cause germ flooding of the organism, starting from the intestine, and eventually lead to septic intoxication. Haemorrhagic diathesis was found to occur only short of death and is thought to result from thrombocytopenia due to damage to thrombopoiesis as well as from septico-toxic effects upon the blood coagulation and partitioning vascular system. Loss of wool (epilation) was recordable only from neck and shoulder regions, and even there it was on the decline.
 ...
PMID:[Pathomorphology of radiation sickness in sheep following whole body roentgen irradiation]. 72 69


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>