Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019079 (hemoptysis)
 6,129 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

HIV-associated tuberculosis (TB) poses an immediate and serious threat to public health, especially in the developing world. Moreover, atypical clinical presentation and unfavorable outcome have been observed in HIV-infected patients with TB. The authors report their findings from an investigation of the impact of HIV infection upon the clinical presentation, response to treatment, and outcome of pulmonary TB. The symptoms, radiographic pattern, sputum direct smear, drug susceptibility, treatment outcome, and adverse reactions of 88 HIV-infected patients seen during January-October 1993 at the Central Chest Hospital, Nonthaburi, Thailand, with newly-diagnosed, culture-proven, untreated pulmonary TB were compared with those of age- and gender-matched HIV-seronegative patients. There were 82 men and six women in each group of mean age 35.6 years, with the majority being aged 16-40. Heterosexual contact was the most common risk factor for HIV infection, with homosexuality implicated in only 1% of all cases of infection. No difference was observed between the two groups in the frequency of pyrexia, dyspnoea, cough, or hemoptysis, although cavitary lesions and upper zone infiltrates were observed significantly less often in the HIV-infected group. Direct smear positivity was comparable in the two groups. Resistance rates to anti-TB drugs were not different except for Streptomycin which was higher among the HIV-infected patients. Cutaneous hypersensitivity reactions and drug-induced hepatitis occurred more often in the HIV-seropositive group, but the difference was not statistically significant. Default was much higher among the HIV-infected, although the culture conversion rate was satisfactory among those who completed treatment. Twelve HIV-infected patients died during the course of treatment, four due to TB. The authors that their findings lead physicians to suspect TB among HIV-seropositive patients and provide them with the appropriate and timely short-course chemotherapy.
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PMID:Clinical aspects and treatment outcome in HIV-associated pulmonary tuberculosis: an experience from a Thai referral centre. 774 73