Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019079 (hemoptysis)
 6,129 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Over a period of four years, 23 patients had the diagnosis of chronic pulmonary hypertension made on the basis of elevated resting pulmonary arterial pressures above 30 mmHg mean. Clinical features included dyspnea (100%), previous thromboembolism (43%), congestive failure (39%), venous thrombosis (35%), syncope (30%), lung disease (22%), recent trauma (22%), hemoptysis (17%) and precordial pain (17%). Pulmonary angiograms showed embolic occlusion in all but four patients, who were considered to have primary pulmonary hypertension. KimRay-Greenfield((R)) vena caval filters were inserted in 18 patients. Three of them were in refractory shock at the time, and only the one who had successful intraluminal catheter embolectomy survived. These patients have been followed an average of 23 months with two embolic deaths, one from the right atrium and one bypassing a filter misplaced in the right iliac vein (overall mortality 22%). There has been no other known recurrent embolism, but one patient developed hematuria from the filter. The five patients who did not receive a filter have all died after intervals up to 18 months. Recurrent thromboembolism was documented in three and suspected in one patient with known embolic disease who died suddenly. Regardless of etiologic factors, pulmonary hypertension with cor pulmonale is associated with a high incidence of fatal thromboembolism. In our experience, maximal protection is afforded by long-term anticoagulation therapy and the placement of a venacaval filter.
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PMID:KMA-Greenfield filter placement for chronic pulmonary hypertension. 44 9

A 24-year-old man admitted to our hospital because of hemoptysis and left precordial pain. Chest X-ray and chest CT scan showed a mass in the left anterosuperior mediastinum. Laboratory examination revealed elevated levels of AFP (550 ng/ml), which were highly indicative of malignant germ cell tumor. Imaging examination indicated that the mass was resectable, so surgery was performed prior to chemotherapy. Histological examination revealed an admixture of seminoma, immature teratoma, embryonal carcinoma and yolk sac tumor. Because the resection performed was incomplete, the patient received three courses of combination chemotherapy consisting of CDDP, VP-16 and BLM and 40 Gy irradiation. The serum level of AFP was normal after one course of combination chemotherapy. The patient has shown no sign of recurrence for 3 years since surgery.
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PMID:[A case of malignant mediastinal germ cell tumor benefited by multidisciplinary therapy]. 874 63