Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0019079 (hemoptysis)
 6,129 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Hepatoid adenocarcinoma of the lung (HAL) is an extremely rare cancer without clear treatment guidance and with a poor prognosis. This report discusses a 64-year-old man who presented with complaints of hemoptysis and was found to have a right upper lobe (RUL) lung mass on chest CT with presence of a right hilar mass and retrocaval lymphadenopathy, and metastasis to the vertebral spine and rib. The patient was diagnosed with T2N2M1 (stage IV) unresectable disease. A biopsy of the RUL mass revealed hepatoid variant adenocarcinoma. Immunohistochemical stains showed tumor cells positive for CK7, AFP, Hep Par 1, napsin A, and cytoplasmic TTF-1 staining. In contrast, CK5, CK6, and CK20 were negative, and EGFR was wild-type. Serum alpha fetoprotein (AFP) level was elevated at 181 ng/mL. The patient was treated with platinum-based doublet chemotherapy and sorafenib, and his AFP level decreased to 25 ng/mL. This case report presents the novel use of sorafenib in combination with platinum-based doublet chemotherapy in EGFR wild-type HAL, which led to a partial response. Single-agent sorafenib led to stable disease overall, achieving a survival among the longest reported for unresectable stage IV, all while maintaining an ECOG performance status of 0 to 1.
 ...
PMID:A novel approach using sorafenib in alpha fetoprotein-producing hepatoid adenocarcinoma of the lung. 2587 Mar 75

Epithelioid angiosarcoma is a rare soft-tissue sarcoma, which originates from endothelial cells. Herein, we report a case of an uncommon morphology of epithelioid angiosarcoma in the chest wall with diffuse hemorrhage and necrosis. The 52-years-old man suffered from severe chest pain, hemoptysis, and fever. Contrast-enhanced chest CT scans showed a large space-occupying lesion in the right chest cavity. A right thoracotomy was performed for definite diagnosis and surgical resection. Microscopically, the specimen demonstrated extensive hemorrhage and necrosis, while few visible tumor cells were noted. These cells were round to polygonal and even had an epithelioid appearance, with abundant eosinophilic cytoplasm. Vesicular nuclei and prominent nucleoli were observed. Immunohistochemistry indicated that these abnormal cells were positive for cytokeratin, vimentin, CD31, ERG, and FLI-1. They were negative for D2-40, CK5/6, calretinin, WT-1, CK7, TTF-1, napsin A, and CEA. Moreover, Ki-67 with MIB-1 was about 40%. On the whole, histology and immunohistochemistry supported the diagnosis of epithelioid angiosarcoma.
 ...
PMID:Epithelioid angiosarcoma of the chest wall with atypical morphology: report of one case. 3193 87