Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019079 (hemoptysis)
 6,129 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Sarcoidosis ranges from asymptomatic lymphadenopathy to debilitating cavitary lung disease and involves surgeons in diagnostic and therapeutic procedures. In 89 patients two died of pulmonary insufficiency from Stage III sarcoidosis. Sixty-two patients underwent 74 diagnostic surgical procedures, with mediastinoscopy most frequently used, yielding 100 per cent diagnostic accuracy. Biopsies of other obviously diseased sites, including lung, liver and skin were effectively used. Surgical treatment of sarcoidosis involved both general and thoracic procedures in seven patients. The severity of pulmonary problems in Stage III sarcoidosis is emphasized in two patients with Aspergillus infections, hemoptysis and Aspergillus empyema with bronchopleural fistula. Sarcoidosis becomes a significant surgical problem in both diagnosis and the treatment of its complications.
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PMID:Surgical problems in sarcoidosis. 51 73

Invasive aspergillosis has increasingly been recognised to cause significant morbidity and mortality in immunocompromised patients. Fever unresponsive to broad-spectrum antibiotics is the earliest and most common sign of an invasive fungal infection. As invasive Aspergillus infections are usually acquired by inhalation of Aspergillus conidia, symptoms of a pulmonary infection such as cough, rales and marked pleuritic chest pain can be noted early in the course, whereas hemoptysis typically comes late after neutrophil recovery. Aspergillus infections of the upper respiratory tract may also involve the nasal cavity or sinuses resulting in nasal obstruction, epistaxis, facial pain, periorbital swelling and even palate destruction. Primary cutaneous infections present as non-purulent ulcerations and may be seen in association with implantable intravenous devices. Other sites of infections, such as the central nervous system, originate from dissemination of molds and may be suspected when focal neurological findings or meningism develop. The recognition of symptoms associated with invasive aspergillosis in patients at risk should prompt further diagnostic procedures, as an early diagnosis and immediate institution of antifungal therapy might improve the treatment outcome in this life-threatening condition.
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PMID:Clinical presentation of invasive aspergillosis. 947

While typical pulmonary infections can be cured with antimicrobial agents, three types require surgical lung resection: those in immunocompromised patients; those with acquired resistance to medication; and those caused by microorganisms against which there are no effective drugs. We discuss these three types from the viewpoint of physicians. With the development of chemotherapy for malignant disease, patients with leukemia can be cured with bone marrow transplantation. During the leukopenia accompanying chemotherapy, Aspergillus sp. can infect the lungs. Aspergillus infections are resistant to antimicrobial agents, and thus surgical resection is necessary. Aspergillus infections may occur in previous sites of pulmonary tuberculosis lesions after the tuberculosis is cured producing massive hemoptysis. In this case, surgical resection is also needed. When patients who are immunocompromised due to various underlying diseases become infected with multidrug-resistant tuberculosis, they require surgical resection. Finally, when lesions of nontubercular mycobacterial infection are found, these patients also require surgical lung resection.
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PMID:[Pulmonary infection in immunocompromised hosts]. 1565 72

Aspergillus infections are rare opportunistic infections in the course of AIDS and they mostly present as invasive pulmonary disease. Owing to the prolonged survival of profoundly immunocompromised patients with AIDS, invasive pulmonary aspergillosis is being reported with increased frequency. However, although pulmonary aspergilloma has been well described in immunocompetent patients, it has been rarely reported in AIDS patients. The treatment for pulmonary aspergilloma remains challenging and often needs lifelong treatment to minimize fatal haemoptysis, which can occur in up to 25%, and progression to secondary invasive aspergillosis. We report a case of pulmonary aspergilloma in a severely immunocompromised patient with AIDS who stopped taking systemic antifungal treatment in April 1998 and remained well with little progression of invasive aspergillosis up until March 2002 when he died of acute pancreatitis related to a drug interaction of didanosine and tenofovir.
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PMID:Long-term suppressive therapy for pulmonary aspergilloma in an immunocompromised man with AIDS. Is it always necessary? 1945 35