Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019079 (hemoptysis)
 6,129 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In a series of 2150 patients subjected to bronchoscopy 94 (4.5%) were found to have tracheobronchomalacia. Tracheomalacia alone was diagnosed in 21 patients (22%), tracheobronchomalacia in 59 (63%) and bronchomalacia alone in 14 (15%). Mild malacic changes were noted in 44 patients (47%), moderate in 38 (40.5%) and severe in 12 (12.5%). The main symptoms were dyspnoea (63%), chronic cough with expectoration (49%) and haemoptysis (33%), and the most frequent concurrent diseases chronic bronchitis (53%), bronchial cancer (27.5%) and pulmonary tuberculosis (19%). Bronchoscopy performed under local anaesthesia enabled the dynamics of the tracea and bronchi to be observed during spontaneous breathing and during coughing, and it is the best available diagnostic procedure. Histologically the number of longitudinal elastic fibres in the pars membranacea was clearly reduced throughout the whole tracheal area in one patient with tracheomalacia but no differences were found in the amount of collagen, mucopolysaccharides and elastin in the cartilages of trachea and bronchi. This disease seems to be associated with chronic obstructive pulmonary diseases such as chronic bronchitis, and it apparently shares the same aetiological factors.
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PMID:Acquired tracheobronchomalacia. 88 58

Indications for using expandable metal stents (EMS) for airway disease have expanded considerably during the past decade. Complications have been infrequent but can be potentially life threatening. There are four reported instances of vascular bronchial fistula after Gianturco EMS insertion for managing airway disease in adults. The authors report a case of an aortobronchial fistula in a pediatric patient after Palmaz EMS insertion for treatment of bronchomalacia. A 14-year-old boy with severe scoliosis underwent left mainstem bronchus insertion of two Palmaz stents in tandem for correction of complete bronchial obstruction caused by vascular compression. Three weeks later fatal hemoptysis from an aortobronchial fistula developed. Elective EMS insertion for treatment of airway obstruction secondary to compression by vascular structures should be approached with caution. EMS placement should be reserved for situations in which there is no other reasonable surgical alternative.
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PMID:Aortobronchial fistula after expandable metal stent insertion for pediatric bronchomalacia. 972 11

The common indications for therapeutic bronchoscopy include relief of benign and malignant airway stenosis, in the intensive care unit, foreign body removal and management of hemoptysis. Debulking of airway tumors may be undertaken using techniques such as laser photoresection, electrocautery, cryotherapy, argon plasma coagulation or mechanically using rigid bronchoscopy. These techniques are often used in combination. Balloon dilatation and insertion of silicone or metallic airway stents can be undertaken to treat benign and malignant strictures or bronchomalacia. Airway stents maintain luminal patency by opposing extrinsic compressive forces or by providing internal support. Certain stent types may also physically prevent (Silicone and covered metallic stents) the encroachment of tumor tissue into the airways. Covered metallic airway stents are safe and effective in the management of malignant tracheoesophageal fistulae, reduce the risk of recurrent aspiration and provide enhanced quality of life by allowing resumption of oral nutrition. In this article, we present an overview of application and the current methods available to perform therapeutic bronchoscopy.
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PMID:Advances in bronchoscopy--therapeutic bronchoscopy. 1590 44