Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019079 (hemoptysis)
 6,129 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Twenty nine selective bronchial arteriographies were carried out in 25 children. In 5 cases the findings were normal. In 1 case an aneurysm of the bronchial artery was demonstrated as the source of the bleeding into the bronchus in a case of Rendu-Weber-Osler syndrome. In 1 case a plasmocytoma and in another one a congenital haemangiomatous network with many anastomoses to the pulmonary circulation was demonstrated. In most cases of chronic inflammatory pulmonary disease, the bronchial arteries were dilated and bronchopulmonary anastomoses were visualized. These changes seemed to be a measure of the extent of the disease and of the severity of the functional disturbance in pulmonary tissue, even when only regional. Selective bronchial arteriography is recommended in all cases of haemoptysis, in chronic pulmonary collapse and in chronic inflammatory lung disease in order to determine the source of the bleeding and the extent of involvement of the pulmonary interstitium.
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PMID:Selective bronchial arteriography in children. 122 73

A case is reported of life-threatening haemoptysis as a result of an anomalous communication between a bronchial artery and pulmonary vein, demonstrated by angiography. The patient recovered following bilobectomy of the right lower and middle lobes. When a systemic artery is involved in an arteriovenous malformation of the lung, haemodynamics are different compared with those present in malformations fed by the pulmonary artery. This implicates other clinical features, options for surgical intervention and prognosis. In reviewing the literature, a relationship with Rendu-Osler-Weber disease is absent in these specific malformations.
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PMID:Systemic to pulmonary vascular malformation. 148 79

Hereditary familial telangiectasis is a vascular dysplasia characterized by a triple syndrome: hereditary character, telangiectasias and hemorrhages. Its association with systemic and/or pulmonary arterio-venous fistulae is frequent and can condition several complications: cerebral abscess, digestive hemorrhages, epistaxis, hemoptysis, hypoxemia, polyglobulia, and rarely the appearance of hemothorax. We describe a patient who was admitted in hospital with a hypovolemic shock secondary to a massive hemothorax; during emergency surgery, which was necessary to perform, a pulmonary A-V fistula was observed in the middle lobe. The studies afterwards performed demonstrated that it was a Rendu-Osler-Weber disease with duodenal, hepatic, and cerebral involvement.
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PMID:[Massive hemothorax: an exceptional complication of Rendu-Osler-Weber disease]. 178 May 31

Arteriovenous fistulas of the lung occur as a disease limited to the lung, or as a pulmonary manifestation of hereditary Rendu-Osler-Weber's disease. Typical complications are haemoptysis, haemothorax and cerebral embolism. We report on 3 patients in whom arteriovenous fistulas of the lung were removed by wedge excision or lobectomy. One of them had already suffered cerebral infarction. The indication for operative removal of single lesions is always given with respect to the severe complications of this disease. Decrease of the right-to-left shunt volume can usually be achieved.
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PMID:[Lung resection in arteriovenous fistula]. 211 37

A case is reported of Rendu-Osler-Weber syndrome presenting in a 9 year old girl as recurrent haemoptysis. Despite a normal chest X-ray, the patient was found to have multiple areas of angiodysplasia in the major airways of her right lung.
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PMID:Rendu-Osler-Weber syndrome in a 9 year old girl presenting with repeated haemoptysis. 259 Jan 22

Arteriovenous fistula of the lung is a relatively rare lesion with various clinical manifestations. It may be clinically silent and discovered by chance on X-ray films of the chest or during evaluation of Rendu-Osler-Weber disease with which it is associated in about one-half of the cases. It may also have loud manifestations when complicated. The fistula is diagnosed in successive steps, mainly by respiratory function tests and pulmonary angiography. Conservative treatment should be the rule, especially in case with multiple fistulae, but it must begin at an early stage to avoid the dramatic complications of this abnormality, such as acute neurological disorders, haemoptysis, haemothorax, etc. Wide and crippling lung resection must be avoided. Aneurysmorrhaphy or embolization is sufficient to cure most of these multiple angiomas. The results obtained are measured by calculating the blood flow rate in the shunt, as it should theoretically disappear after surgery.
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PMID:[Pulmonary arteriovenous fistula. Apropos of 12 cases]. 263 89

Pulmonary arteriovenous fistulas are rare congenital malformations associated in 40% of cases with Osler-Weber-Rendu disease. PAF acquired in connection with the chest trauma, surgery and some inflammatory or neoplastic lung diseases were also described. In the Institute of Tuberculosis and Chest Diseases we have observed 11 cases of congenital PAF in 4000 resected lungs during the last years. In this report we described one more case with PAF. A 40 years old man was admitted to the Institute of Tuberculosis and Chest Diseases with hemoptysis. History and physical examination was unremarkable. Chest roentgenogram revealed a right upper lobe infiltrate. Tuberculosis or cancer was suspected and during the diagnostic procedures antituberculous drugs were given. After 3 weeks of treatment hemoptysis increased and chest roentgenogram revealed progression of the infiltrate in the right upper lobe and new lesions in the middle lobe. According to the character of X-ray progression which night be characteristic of active bleeding, a possibility of arteriovenous fistulas could not be excluded. As life threatening haemorrhage persisted right upper lobectomy without angiography was done. In the resected lobe arteriovenous fistulas were found. Angiography after operation was proposed but was refused by the patient. He is now well and symptoms free 5 months.
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PMID:[Pulmonary arteriovenous fistulas]. 771 64

Rendu-Osler-Weber disease is an hereditary disorder characterized by cutaneo-mucous telangiectasis and vascular abnormalities in several organs. Bleeding, especially epistaxis, represents the most important clinical feature. Pulmonary arteriovenous fistulae can cause hypoxaemia, haemoptysis, polycythaemia and clubbing. Diagnosis is based on family and personal history, teleangiectasis, laboratory (haemochrome, fibrinogen, PT, PTT) and instrumental findings (endoscopy and/or roentgen). Therapy depends on symptoms. Embolization of pulmonary arteriovenous fistulae and laser treatment of intestinal vascular abnormalities have been successful. Danazol treatment yielded controversial results. We report the case of a patient admitted for arterial hypertension and recurrent epistaxis. Rendu-Osler-Weber disease diagnosis was made based on positivity at family and personal history, clinical examination, laboratory and instrumental findings. In conclusion we underline the pivotal role of anamnesis and clinical examination in the differential diagnosis of hereditary bleeding disorders and emphasize the importance of early diagnosis for the correct therapeutic approach.
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PMID:[Rendu-Osler-Weber disease. Report of a clinical case]. 899 9

Pulmonary arteriovenous fistula (PAVF) is an abnormal connection between pulmonary arteries and veins. Patients with PAVF may have the Rendu-Osler-Weber syndrome, a disease transmitted by autosomal dominant mechanisms. Here we describe a case of PAVF in a 56-year-old woman, who was admitted to our department because of dyspnea, hemoptysis, and a mass in the left lower lung found on chest X-ray. The diagnosis of PAVF was suspected according to clinical and physiological criteria and confirmed by magnetic resonance imaging of the chest. The PAVF was removed by left lower lobectomy. Anamnestic and clinical investigations of the patient's relatives led to the diagnosis of the Rendu-Osler-Weber syndrome.
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PMID:Pulmonary arteriovenous fistula in a patient with Rendu-Osler-Weber syndrome. 931 Oct 54

A 19-year-old woman complaining of exertional dyspnea was admitted to our hospital with an abnormal shadow on the left side of the chest. Laboratory examination revealed polycythemia and hypoxemia. Pulmonary angiogram demonstrated a pulmonary arteriovenous fistula beneath the surface of the left S10. Partial resection of the left S10 was performed. The wall of the arteriovenous fistula was flimsy and seemed to rupture easily. The sister of this patient also had a peripheral pulmonary arteriovenous fistula and suffered from repeating epistaxis. Rendu-Osler-Weber disease was diagnosed in both, and the sister underwent partial resection of the right S7, which contained the fistula. Their postoperative courses were uneventful. Hemothorax and hemoptysis are lethal complications of arteriovenous fistulae. In order to avoid the rupture of fistulae, surgical resection is the most reliable treatment. Pulmonary arteriovenous fistulae beneath the surface of the lung should be resected.
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PMID:[A case of pulmonary arteriovenous fistula beneath the surface of the lung]. 961 53


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