Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0019045 (hemoglobinopathies)
 2,704 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
hemoglobin 1061
erythroid 198
beta-globin 166
Sep 153
Mol 128
methemoglobin 94
HBB 80
ferritin 63
gamma-globin 56
BCL11A 48
HLA 48
erythropoietin 36
CD34 29
She 24
HBA2 23
transferrin 22
beta globin 21
AAG 19
alpha globin 19
gamma globin 17
Rad 17
melanin-concentrating hormone 17
histone deacetylase 16
human leukocyte antigen 16
B12 16
glucose-6-phosphate dehydrogenase 16
Cad 15
albumin 15
B19 15
KLF1 15
haptoglobin 15
histone 14
HBA1 14
P50 13
MYB 13
hematopoietic stem and progenitor cells 13
GTG 12
cytokine 12
MRI 12
SCD 11
HBG1 11
HBG2 11
gamma chain 11
polypeptide 11
HS2 10
cystatin C 10
zinc finger 10
chronic renal failure 10
collagen 9
FAS 9
pseudoxanthoma elasticum 9
alpha-chain 9
hemochromatosis 9
delta-globin 9
MED 9
HBD 8
CAC 8
p50 8
lymphoid 8
Hop 8
ARMS 8
transferrin receptor 8
FAC 8
fused 8
endonuclease 8
GATA-1 8
HBS1L 7
SWI 7
GATA1 7
prothrombin 7
lactate dehydrogenase 7
E11 7
ABO 7
CAR 7
LDH 7
gut 7
ankyrin 6
G6PD 6
Erythropoietin 6
glycophorin A 6
TAT 6
ATP 6
fibrinogen 6
insulin 6
H14 6
I-1 6
membrane protein 6
SMARCB1 6
reserved 6
vascular endothelium 6
LRF 6
CD8 6
EKLF 6
Polymerase 6
SCT 6
kit 6
SOX6 5
superoxide dismutase 5
tissue factor 5
EPO 5
San 5
protein C 5
Dakar 5
beta globin chain 5
interferon 5
factor VIII 5
JAMA 5
ZBTB7A 5
hemophilia A 5
CD4 5
pyruvate kinase 5
CML 5
severe combined immunodeficiency 5
X-linked 5
heme-regulated inhibitor 5
C-reactive protein 5
A-I 5
Poly 4
Mil 4
alkaline phosphatase 4
IDA 4
protein S 4
HS1 4
hemopexin 4
p38 4
AAT 4
Hepcidin 4
MHC 4
Met 4
GAA 4
HDAC1 4
DNMT1 4
IgA 4
ROS 4
GAT 4
SDS 4
A14 4
alpha, beta 4
von Willebrand factor 4
UTR 4
hereditary hemochromatosis 4
BP1 4
TCR 4
glycoprotein 4
serum albumin 4
LSD1 4
thrombin 4
thymus 4
ESI 4
antithrombin III 4
transcriptional repressor 4
methyltransferase 4
P40 4
biotinidase 4
Mal 4
AE1 4
HS3 4
CD45 4
mutant beta-globin 4
Haptoglobin 3
more...
Disease
hemoglobinopathies 2704
thalassemia 948
sickle cell disease 809
anemia 350
thalassemia major 121
hemolytic anemia 114
malaria 103
beta thalassemia 95
cancer 95
iron deficiency 91
HBB 80
HBB 80
HBB 80
diabetes 77
iron overload 72
thalassemia trait 66
graft-versus-host disease 47
stroke 42
tumor 41
leukemia 40
infectious diseases 37
G6PD deficiency 36
hypertension 36
hereditary persistence of fetal hemoglobin 34
immunodeficiency 34
alpha thalassemia 33
cystic fibrosis 31
West 31
sepsis 31
iron deficiency anemia 31
microcytic anemia 31
ischemia 30
HIV 30
genetic disorder 30
retinopathy 29
acute chest syndrome 28
erythrocytosis 25
pulmonary hypertension 25
aplastic anemia 24
thalassemia minor 24
osteomyelitis 23
hematologic malignancies 23
hereditary spherocytosis 22
haemophilia 22
parvovirus 22
sepsis 22
erythroleukemia 21
gallstones 21
thrombocytopenia 20
renal disease 20
myelodysplastic syndrome 19
osteoporosis 18
phenylketonuria 18
AIDS 18
systemic lupus erythematosus 18
priapism 18
tuberculosis 18
malnutrition 17
pneumonia 16
polycythemia 16
heart disease 15
hypochromic anemia 15
Bellini duct carcinoma 15
blood disorder 15
hepatitis B 15
renal failure 14
carcinoma 14
retinal detachment 14
chronic renal failure 13
acute myeloid leukemia 12
splenic infarction 12
enzyme deficiency 12
lymphoma 12
Sickle cell trait 12
HPFH 12
multiple myeloma 12
Salmonella osteomyelitis 12
SCD 11
abortion 11
arthritis 11
vascular disease 11
bacteremia 11
asthma 11
hepatitis 11
methemoglobinemia 11
congenital hemolytic anemia 10
chronic myeloid leukemia 10
folate deficiency 10
congenital hypothyroidism 10
pseudoxanthoma elasticum 10
FAS 10
cirrhosis 10
Hb SC disease 10
paroxysmal nocturnal hemoglobinuria 10
CAA 9
CAA 9
renal cell carcinoma 9
hypothyroidism 9
fat embolism 9
moyamoya 9
Down syndrome 9
proteinuria 9
sickle cell crisis 9
cold 9
liver disease 9
rheumatoid arthritis 9
metastases 9
hemochromatosis 9
myeloproliferative disorders 8
angioid streaks 8
leg ulcers 8
Plasmodium falciparum malaria 8
confusion 8
polycythemia vera 8
hyperbilirubinemia 8
galactosemia 8
neutropenia 8
meningitis 8
sarcoidosis 8
Gaucher disease 8
depression 8
hepatitis C 8
von Willebrand disease 8
HBD 8
prematurity 7
Infection 7
autoimmune hemolytic anemia 7
NAME 7
hypoglycemia 7
SCID 7
cytomegalovirus 7
respiratory failure 7
hookworm 7
autoimmune disease 7
renal papillary necrosis 7
alcoholism 7
pyruvate kinase deficiency 7
rash 7
chronic pain 7
glaucoma 7
arthropathy 7
Tay-Sachs disease 7
Haemophilia 7
immune deficiency 7
vitamin B12 deficiency 7
hemosiderosis 7
rare disease 6
cerebral infarction 6
DBA 6
multiple sclerosis 6
infertility 6
Haemophilus 6
toxoplasmosis 6
anemia of chronic disease 6
hyperparathyroidism 6
hyposplenism 6
preeclampsia 6
uterus 6
lupus 6
thrombocytopenic purpura 6
more...
Symptom
pain 67
splenomegaly 46
cyanosis 18
anesthesia 16
abdominal pain 12
hepatosplenomegaly 11
weakness 9
headache 9
seizures 7
collapse 7
chest pain 7
fatigue 6
dyspnea 6
flank pain 5
pallor 5
back pain 4
shortness of breath 4
diarrhea 4
hypothermia 4
analgesia 4
cough 4
erythema 3
overweight 3
bone pain 3
hypercapnia 3
acute pain 3
ataxia 3
acute abdominal pain 2
hepatomegaly 2
chills 2
knee pain 2
Reticulocytosis 2
arthralgia 2
dizziness 2
low back pain 2
vomiting 2
thinning 2
exhaustion 2
exertional dyspnea 2
lassitude 1
clubbing 1
hemoptysis 1
atypical chest pain 1
sleepiness 1
dysarthria 1
tachypnea 1
limb pain 1
dysuria 1
regurgitation 1
starvation 1
left upper quadrant pain 1
peau d'orange 1
stigma 1
pelvic pain 1
tonic-clonic seizure 1
Ill 1
facial pain 1
fever of unknown origin 1
discomfort 1
bitter taste 1
spasm 1
acute abdomen 1
renal colic 1
clumsiness 1
lightheadedness 1
abdominal discomfort 1
syncope 1
Tenderness 1
acidity 1
respiratory distress 1
myalgia 1
nausea 1
periorbital edema 1
hip pain 1
chorea 1
epigastric pain 1
Neonatal cyanosis 1
paresthesia 1
anorexia 1
ankle pain 1
discomfort 1
nausea and vomiting 1
chronic back pain 1
angina 1
muscle stiffness 1
oliguria 1
Penile pain 1
Roth spots 1
hemiplegia 1
dental pain 1
constipation 1
ophthalmoplegia 1
Drug
Asn 11
VCR 8
lysine 7
Leaf 6
ascorbate 6
TAT 6
Fluorescein 5
Dermatol 5
Deferasirox 5
Dakar 5
Fluorescein 5
Cellulose acetate 4
ROS 4
Heme 4
Nephron 3
FAD 3
Bayer 3
MDS 3
G-CSF 3
Azacytidine 2
ampicillin 2
Benserazide 2
Prednisone 2
MAP 2
Cardiovasc 2
Asthma 2
Nephron 2
Vorinostat 2
IFN-gamma 2
vitamin E 2
Sodium phenylbutyrate 1
AGG 1
Sodium propionate 1
TAC 1
ID2 1
Colombo 1
CSF 1
TTC 1
Kenyan 1
PTC 1
Methylene blue 1
Fludarabine 1
Desferal 1
Fansidar 1
DDAVP 1
AZT 1
CTX 1
G418 1
EPI 1
SMP 1
DNase I 1
CAM 1
Epoetin alfa 1
CTX 1
Fansidar 1
Dial 1
Maraviroc 1
Salbutamol 1
Monit 1
Activin 1
NADH 1
Tenofovir disoproxil fumarate 1
Portal 1
Campath 1
Lenalidomide 1
Campath 1
NAG 1
Lovastatin 1
Desferal 1
Dacogen 1
ROC 1
Gel 1
CTX 1
DDAVP 1
Viagra 1
Methylprednisolone 1
ACT 1
PMPA 1
Ranibizumab 1
Isopaque 1
Fosamax 1
AZT 1
Enzyme
ERK 23
glucose-6-phosphate dehydrogenase 19
endonuclease 8
lactate dehydrogenase 7
TAT 6
mitogen-activated protein kinase 5
aspartate aminotransferase 5
peroxidase 5
superoxide dismutase 5
APC 5
catalase 5
pyruvate kinase 5
thrombin 4
biotinidase 4
aldehyde dehydrogenase 4
arginase 4
alkaline phosphatase 4
RNA polymerase 4
trypsin 4
adenosine deaminase 3
ceruloplasmin 3
adenosine deaminase 3
GCA 3
proteasome 3
methylenetetrahydrofolate reductase 3
methylenetetrahydrofolate reductase 3
RNase 3
luciferase 3
DNA methyltransferase 3
alanine aminotransferase 2
creatine kinase 2
BMT 2
ATPase 2
protein kinase 2
PHD 2
ACE 2
acyl-CoA dehydrogenase 2
xanthine oxidase 2
NADPH oxidase 2
caspase-3 2
RNase 2
reverse transcriptase 2
phosphoglycerate kinase 2
DNase 2
thromboplastin 2
aldehyde dehydrogenase 1
SOR 1
beta-galactosidase 1
deoxyribonuclease 1
tissue plasminogen activator 1
aldehyde dehydrogenase 1
CDH 1
focal adhesion kinase 1
phosphodiesterase 1
type III procollagen 1
phosphoglyceromutase 1
CDR 1
histone demethylase 1
hexokinase 1
AST 1
calcineurin 1
factor C 1
phosphofructokinase 1
PRPP synthetase 1
peroxiredoxin 1
glutathione reductase 1
glutathione peroxidase 1
NO synthase 1
cdc2 1
HCS 1
AOR 1
ALA synthase 1
argininosuccinate synthetase 1
aldehyde dehydrogenase 1
heme oxygenase 1
ornithine transcarbamylase 1
aldehyde dehydrogenase 1
PKG 1
NADPH oxidase 1
glutathione S-transferase 1
transglutaminase 1
cytidine deaminase 1
MDP 1
HDR 1
prolidase 1
Mg2+-ATPase 1
ACS 1
renin 1
PGM 1
NQO1 1
SNO 1
MEK 1
carbonic anhydrase 1
succinate dehydrogenase 1
citrate synthase 1
SMP 1
deoxyribonuclease 1
chymotrypsin 1
fumarase 1
DNA polymerase 1
argininosuccinate lyase 1
cytochrome oxidase 1
SOR 1
ornithine aminotransferase 1
Compound
Hemoglobin 355
Clin 272
DNA 263
iron 193
Dec 152
oxygen 139
HBB 80
glucose 35
lysine 34
acetate 33
Asp 26
His 25
Hydroxyurea 21
urea 20
arginine 20
zinc 19
MCH 17
alanine 16
sodium 16
leucine 15
nitric oxide 14
tyrosine 14
butyric acid 13
valine 13
creatinine 12
GTP 12
proline 11
water 11
glutamic acid 10
calcium 10
Benin 10
EDTA 10
Gly 10
methionine 10
EDTA 9
CAA 9
threonine 8
isopropanol 8
LCR 8
butyric acid 8
glutamine 7
aspartic acid 7
aspartic acid 7
phosphate 7
butyric acid 7
aspartic acid 7
aspartic acid 7
potassium 6
2,3-diphosphoglycerate 6
copper 6
ATP 6
TEM 6
Cardiol 6
hydrogen 6
Phe 5
DPG 5
Pac 5
CO2 5
DPG 5
Retinal 5
nitrogen 4
cysteine 4
DFO 4
BTT 4
IDA 4
H2O2 4
AAT 4
Heme 4
Ile 4
SDS 4
salt 4
Hemin 3
Hemin 3
silver 3
TAA 3
Adrenal 3
Hemin 3
Hemin 3
barium 3
GSH 3
iodine 3
Bantu 3
aluminum 3
cyanide 3
selenium 3
GSH 3
Hemin 3
nitrate 3
CAM 3
Busulfan 3
ASA 3
Optimal 3
galactose 3
FAD 3
serine 3
Histone 2
TOF 2
retinol 2
Lawson 2
CAT 2
asparagine 2
Diabetol 2
NBS 2
pyrimidine 2
AAA 2
formic acid 2
ammonia 2
Triton X-100 2
formic acid 2
isoleucine 2
PMA 2
pyrimidine 2
Rofecoxib 2
formic acid 2
Progesterone 2
Valproic acid 2
cAMP 2
formic acid 2
formic acid 2
Belt 2
G11 2
Cap 2
Curcumin 2
formic acid 2
ACI 2
ATA 2
formic acid 2
acrylamide 2
ADP 2
acetonitrile 2
phosphorus 2
ADP 2
DAC 2
ADP 2
vitamin D 2
Prednisone 2
GGG 2
SCN 2
CAT 2
TSH 2
CoA 2
formic acid 2
hexose 2
Abbott 2
Isoproterenol 2
DEAE 2
Diabetol 2
formic acid 2
CAT 2
Triton 2
Glucose 6-phosphate 2
GMP 2
bromide 2
Tributyrin 2
CAP 2
Tris 2
ammonium 2
Sildenafil 2
ABA 2
glutamate 2
more...