Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0019045 (
hemoglobinopathies
)
2,704
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We determined serum levels of laminin and aminoterminal propeptide of
type III procollagen
(PIIINP) in 20 patients with sickle cell
hemoglobinopathies
. Elevated levels of soluble laminin and PIIINP were observed in the patients--1.5 +/- 0.3 U/ml (mean +/- SD) (range 1.1-1.9 U/ml) and 0.90 +/- 0.2 U/ml (range 0.6-1.4 U/ml), respectively, compared to normal controls, 1.3 +/- 0.1 U/ml (range 1.2-1.4 U/ml) for laminin and 0.7 +/- 0.1 U/ml (range 0.6-0.9 U/ml) for PIIINP. The serum laminin and PIIINP were significantly elevated (p < 0.02 and p < 0.001, respectively, in patients with sickle cell
hemoglobinopathies
). There was no correlation between serum laminin and PIIINP levels in the patient group. The study indicates that aminoterminal propeptide of
type III procollagen
and laminin can be utilized as valuable non-invasive markers of possible alterations in extracellular matrix in bone marrow, spleen, kidney or other tissues in sickle cell
hemoglobinopathies
.
...
PMID:Serum concentrations of laminin P1 and aminoterminal propeptide of type III procollagen in sickle cell disease. 970 58
