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Query: UMLS:C0019045 (hemoglobinopathies)
 2,704 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Hemoglobinopathies and specially drepanocytosis SS and its heterozygotic form SC are responsible of important pathological changes of retina. These changes caused by ischaemia due to vascular thrombosis are generally silent at their beginning, because of their first development in a peripheral area. They have a tendency to progress towards the posterior pole and to get complicated by hemorrhages and detachment of retina. Their study is still to be completed but these disorders already appear as being an important cause of blindness in the populations concerned by this hemoglobinopathy. Treatment is unsatisfactory.
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PMID:[Drepanocytic retinopathy (author's transl)]. 72 66

Hemoglobinopathies are a group of hereditary diseases that cause quantitative or qualitative changes in the shape, function or synthesis of hemoglobin. One of the most common is sickle cell anemia, which, due to sickling of erythrocytes, causes vaso-occlusive phenomena. Among the possible ocular manifestations, the most representative is retinopathy, which can lead to blindness if left untreated. Therefore, periodic ophthalmologic monitoring of these patients is important for early diagnosis and adequate therapeutic management, which can be done localy by treating the lesions in the eyes, or systemically.
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PMID:Sickle cell retinopathy: A literature review. 2948 76