Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0019045 (hemoglobinopathies)
 2,704 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 12-year-old girl with sickle cell hemoglobinopathy presented with a Salmonella osteomyelitis of her right humerus requiring six weeks of parenteral antibiotic therapy. Home therapy was evaluated. Due to the frequency of the medication administration (every six hours) and the apprehension of the family members, a Pharmacia-Deltec CADD-VT Infusion Pump was chosen for drug administration. Based on the stability of ampicillin, 1.3 g q6h was administered to provide a minimum of 1 g for the last dose of a 24-hour cycle. Ampicillin 6 g contained in 100 mL of sterile water for injection provided a 60 mg/mL solution with an osmolarity of 347 mOsmol. The pump was programmed to deliver 22 mL of solution over one hour, every six hours. A keep-vein-open rate of 0.2 mL/h maintained line patency. A 100 mL cassette of solution prepared daily was replaced on the pump by a home therapy nurse each morning. At the end of six weeks of therapy, the osteomyelitis was eradicated. We found the use of an ambulatory infusion pump an effective, convenient, and cost-saving method of treatment for our patient.
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PMID:Use of an ambulatory infusion pump in a 12-year-old with Salmonella osteomyelitis. 272 25

Salmonella osteomyelitis of the hand unassociated with hemoglobinopathy developed in a 39-year-old woman. After 11 debridement and curettage operations on the affected finger, she was successfully treated with excision of the diseased bone and reconstruction with a silicone prosthesis and extensor indicis transfer. This patient, examined 19 years after the onset of symptoms, illustrates that Salmonella osteomyelitis may persist for an exceedingly long period when limited curettage is the only method of treatment.
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PMID:Chronic osteomyelitis of the hand caused by Salmonella typhimurium. A case report. 327 12

The increased incidence of Salmonella osteomyelitis in patients with sickle cell disease has never been entirely explained. Problems such as cholelithiasis, intestinal infarction, and frequent antibiotic use in this population could possibly result in prolonged or chronic intestinal carriage of Salmonella after acute gastroenteritis. If prolonged carriage were a factor in the pathogenesis of osteomyelitis, attempts to eliminate the Salmonella with antibiotics would be indicated. We did a stool culture survey of 71 patients attending our pediatric sickle cell clinic to determine the incidence of asymptomatic Salmonella carriage. At least two rectal swab cultures were obtained from each patient; 69% of patients also mailed in a stool sample for culture. No Salmonella was isolated. It therefore appears unlikely that prolonged intestinal Salmonella carriage is an important mechanism in the development of Salmonella osteomyelitis in patients with major sickle hemoglobinopathies.
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PMID:Intestinal Salmonella carriage in patients with major sickle cell hemoglobinopathies. 397 46

A case of septicemia owing to Salmonella choleraesuis with localization in the lumbar spine and left knee is described. The spinal lesion is dominated by tuberculoid granulomas with or without central necrosis. The necrotic foci within some granulomas show heavy polymorph infiltration, whereas in others they simulate caseous necrosis and are indistinguishable histologically from tuberculosis, brucellosis, and fungal infections. As Salmonella osteomyelitis has a strong tendency to chronicity if antimicrobial treatment is delayed, inappropriate, or inadequate, this diagnosis should be considered in all cases of granulomatous osteomyelitis, especially when the patient is immunosuppressed or has hemoglobinopathy.
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PMID:Salmonella osteomyelitis. An important differential diagnosis of granulomatous osteomyelitis. 409 Nov 85

Salmonella typhi osteomyelitis is an uncommon disease, usually associated with sickle cell anemia and other hemoglobinopathies, as well as with other disease states. In this case, Salmonella osteomyelitis was apparently caused by hematogenous spread after typhoid or enteric fever. After bone debridement, a segmental defect of the midradius resulted. Normal function was restored after radical debridement, intravenous antibiotics, and delayed tricortical iliac crest bone grafting of the segmental defect.
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PMID:Hematogenous Salmonella typhi osteomyelitis of the radius. A case report. 795 82

Salmonella osteomyelitis is an uncommon disease, usually associated with sickle cell anemia and other hemoglobinopathies, as well as with other disease states. In this case, osteomyelites was apparently caused by hematogenous spread of an enteric infection by Salmonella enteritidis. Bone involvement, in vertebral bodies, was resolved after prolonged clinical treatment with antibiotics. We discuss the pathogeny and compare the findings of four case with others related in literature.
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PMID:[Osteomyelitis by Salmonella enteritidis and sickle cell hemoglobinopathy. Report of a case and review of the literature]. 903 99

Salmonella osteomyelitis is a rare condition that has been associated with patients having hemoglobinopathies or immunosuppression. Healthy patients with no underlying medical history have been known to have Salmonella osteomyelitis develop. Salmonella infection secondary to reptile exposure is an increasing condition in the United States. Several manifestations of salmonellosis have been described in the literature, but no cases of reptile associated bone or joint infections have been reported. The authors present a case of a 7-month-old girl who contracted Salmonella osteomyelitis of her proximal humerus with septic arthritis of the glenohumeral joint secondary to iguana exposure.
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PMID:Salmonella osteomyelitis secondary to iguana exposure. 1073 34

Salmonella species are rare bacterial isolates in osteomyelitis. This article describes a case of an otherwise healthy, active duty male military member with an insidious onset of right knee pain during a deployment to Kuwait. His work-up revealed an infectious process in the distal femur. Operative treatment and intravenous antibiotics resolved the infection. Intraoperative cultures revealed the rare isolate Salmonella enterica serotype C2 (Newport). Postoperative medical management revealed new-onset diabetes mellitus, possibly making this otherwise healthy host susceptible to this rare infection. Salmonella are gram-negative bacteria. Infection with nontyphoidal Salmonella species most commonly manifests as intestinal illness. Although it may be difficult for clinicians to accurately predict this rare entity as the causative organism in osteomyelitis, they may be aided by a history of travel to endemic regions or exposure to animal carriers. Comorbidities that seem to increase susceptibility include diabetes mellitus, human immunodeficiency virus, hemoglobinopathies, and immunosuppression. Blood cultures are reported to be frequently positive in cases of Salmonella osteomyelitis. Identification of Salmonella species from intraoperative cultures should prompt consultation with the infectious disease department for culture-specific antibiotic tailoring. Many common antibiotic agents active against gram-negative organisms seem efficacious. As in this case, following the basic tenets of osteomyelitis management should lead to an acceptable outcome.
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PMID:Salmonella osteomyelitis in new-onset diabetes mellitus. 1975 Sep 96

Salmonella osteomyelitis in children is an uncommon condition, typically associated with hemoglobinopathies or other underlying disorders. Only few cases have been reported in children without predisposing factors. We describe 4 cases of Salmonella osteomyelitis in otherwise healthy children. Since treatment duration is expected to be prolonged, the practice of direct inoculation of aspirates into blood culture bottles appears to be essential for diagnosis and targeted therapy.
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PMID:Salmonella Osteomyelitis in Previously Healthy Children: Report of 4 Cases and Review of the Literature. 2641 43

Salmonella osteomyelitis is well-described in children with hemoglobinopathies, particularly infection with Salmonella typhi. To characterize nontyphoidal osteomyelitis in otherwise healthy children without hemoglobinopathies, we performed a retrospective review of children discharged from our institution with this condition, supplemented with a systematic literature review. Among the 46 subjects identified, common risk factors for Salmonella infection were frequently absent and complications were common.
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PMID:Nontyphoidal Salmonella Osteomyelitis in Immunocompetent Children Without Hemoglobinopathies: A Case Series and Systematic Review of the Literature. 2813 44


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