Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0019045 (hemoglobinopathies)
 2,704 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Twenty-seven children with major sickle hemoglobinopathies underwent elective cholecystectomy for cholelithiasis. All were managed with a preoperative transfusion regimen to achieve a hemoglobin concentration of 11-14 g/dl with greater than 65% hemoglobin A. Intraoperative cholangiography revealed common bile duct stones in five patients, although only one case was diagnosed by preoperative ultrasonographic examination. Twenty-four children underwent incidental appendectomy by total intussusception. There were no vaso-occlusive events nor any other perioperative morbidity or mortality. Four months after cholecystectomy, one boy had a small bowel obstruction requiring surgical re-exploration. No patients had transfusion-acquired infection, although one boy had erythrocyte allosensitization to Lewis A antigen. This preoperative transfusion regimen and careful perioperative management permits safe elective cholecystectomy in children with sickle cell disease.
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PMID:Elective cholecystectomy in children with sickle hemoglobinopathies. Successful outcome using a preoperative transfusion regimen. 338 43

The criteria for assessing female sterilization techniques are safety, effectiveness, and economy. Comparison is made between interval minilaparotomy and laparoscopy. The equipment necessary and surgical techniques followed for both these procedures is described. The operative equipment necessary for laparoscopy is extensive. The mini-laparotomy requires only some type of instrument for elevating the uterus. There are no distinct contraindications for use of the mini-laparotomy while there are 3 clear and 2 relative contraindications against laparoscopy. These are: cardio-respiratory decompensation, sickle hemoglobinopathy, hernias, peritonitis, and intestinal obstruction. The complications which are unique to laparoscopy derive from the necessity to create the pneumoperitoneum in that procedure. Comparison of complications experienced and subsequent pregnancies with both procedures is made though a literature search; the comparison involves several laparoscopic studies and 1 large mini-laparotomy study. Results of the comparison are tabulated.
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PMID:Interval mini-laparotomy: an alternative to laparoscopic sterilization? 644 8