Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0018991 (hemiplegia)
 3,997 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This is the case report of a 44-year-old woman presented with an acute stroke immediately after electroconvulsive therapy (ECT). The patient had no significant medical history other than chronic depression. She was taking sertraline, and she had had multiple previous ECT treatments without any complications. While being monitored in the recovery room within 10 minutes after the last ECT session, she was found to have sudden onset of left-sided flaccid hemiplegia and numbness along with slurred speech. On arrival to our hospital, she was found to have flaccid hemiplegia on the left side involving the face, arm, and leg (face and arm more than the leg involvement), severe dysarthria, and mild neglect syndrome (National Health Institute Stroke Scale of 14). Noncontrast computed tomography (CT) of the head showed no signs of early ischemia, and iodine contrast CT angiography revealed right middle cerebral artery (MCA) (distal M1 segment) clot. Patient received intravenous recombinant tissue plasminogen (rt-PA) at 2.5 hours after the onset of symptoms, and then a total of 3.0 mg of intra-arterial (IA) rt-PA. Angiography at the end of the procedure showed successful recanalization of the M1 segment and normal vessel caliber with adequate distal flow. After the procedure, the patient made rapid improvements in all of her initial symptoms during the first 24 hours. An extensive stroke workup failed to reveal any cause of the stroke, including usual stroke and hypercoagulable risk factors. This was an acute embolic stroke immediately following an ECT, and without the aggressive thrombolytic therapy, the patient's outcome would have been poor because there was an M1 segment clot with a major MCA syndrome with relatively high National Institute of Health Stroke Scale. The neurological side effect profile of ECT is reported to be minimal with most common symptoms being headache, disorientation, and memory complaints. There is no clear cause-and-effect relationship in this case, and the stroke after ECT is extremely rare. In such rare event of stroke while receiving ECT, there is an effective treatment available using both intravenous and IA thrombolysis as reported in this case.
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PMID:Acute embolic stroke after electroconvulsive therapy. 1663 11

Hamburger, former colleague of Thomassen at the Veterinary School in Utrecht, and then professor of Physiology in Groningen, reviewed the career and merits of Thomassen. After graduation as veterinary surgeon (Utrecht 1869) Thomassen developped a succesful veterinary practice in Maastricht, in the neighbourhood of which city he was born. He attracted attention by his publications in foreign veterinary journals. In 1881 he was appointed as clinical teacher at his old school. Next to internal medicine, his teachings encompassed diagnostics, general therapy, pharmacology and history of veterinary medicine. His inquiring spirit led him to manifold investigations. His therapy of bovine actinomycosis by potassium-iodine (1885) was that succesful that the American government set up a committee of inquiry, that only could confirm the effectiveness. The field of nervous diseases in domestic animals was hardly developed at his time. His broad and systematic research on the pathology and etiology of laryngeal hemiplegia was masterly executed. It was followed by a great number of investigations on the disorders of the peripheral and central nervous system. He made himself familiar with the necessary technics of microscopical pathological investigation. He devoted his attention also to the emerging field of bacteriology and its clinical implications. He studied endocarditis acuta in the horse, bacterial nephritis in calves, chronic nephritis in horses, but especially tuberculosis. His transmission experiments showed reciprocal infectivity of tuberculosis between animals and man. Therefore, he could rightfully oppose Robert Koch, who proclaimed the non-infectivity of bovine tuberculosis for humans at the International Tuberculosis Congress in London of 1901. The author draws a contrasting picture of Thomassen's results with the poor surroundings at the Veterinary School in his days and the shortage of tools that he had at his disposal. His true genius and original mind could overcome those difficulties. His wide range of talents manifested itself in his cultivation of the art of singing, his language abilities and his historical writings on Dutch national history of the 16th century and on veterinary medicine in classical Antiquity. He was an excellent teacher and very much appreciated as speaker at international congresses.
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PMID:[Oration held at the occasion of the bestowal of the honorary doctor's degree to M. H. J. P Thomassen by the Senate of the University of Groningen on 21 June 1905]. 2064 35

Isospora belli is a coccidian protozoon that can cause serious diarrhea especially in immunocompromised patients. The laboratory diagnosis depends primarily on the identification of oocysts in stool specimens by direct microscopic examination with iodine or special stains. This case is presented in order to draw attention to isosporiasis among the diarrheas that can be seen in elderly patients with several chronic diseases. A 81 year-old debilitated male, who had a history of hypertension, Alzheimer's disease, previous cerebrovascular accident and right hemiplegia, was admitted to our hospital complaining of malaise, anorexia, chills, abdominal pain, dysuria, cough, sputum and diarrhea of ten days duration. I. belli oocysts were detected by microscopic examination of the sample with iodine after concentration by formalin-ethyl acetate sedimentation. Then, modified acid-fast and trichrome stains were performed and I. belli oocysts were detected with both methods. Similar to this case, infections caused by I. belli can occur in elderly immunocompromised patients with several chronic diseases and inadequate nutrition and care. Consequently, in individuals with persistent diarrhea, examinations and tests should be carried out by taking their immune status into consideration and stool examinations should be done at frequent intervals using the concentrations methods and special stains.
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PMID:[Isosporiasis in an elderly patient with chronic diseases: case report]. 2419 29