Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0018991 (hemiplegia)
 3,997 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We present a 50-year-old female who experienced generalized convulsion 3 months after a successful cadaveric renal transplantation. The first cerebral CT scan indicated cerebral frontal infarction. Repeat CT some days later revealed progressive lesions, and a highly malignant tumor or abscess was suspected. Antifungal and broad-spectrum antibacterial therapy was initiated. Cerebral MRI could not differentiate between these conditions, but a neutrophil granulocyte scan strongly suggested an infectious process. A stereotactic puncture of the frontal lobe was followed by temporary improvement. A severe progressive left-sided hemiparalysis gave indication for a craniotomy with evacuation of the abscess 9 days later. Culture of aspirated pus yielded growth of a gram-positive, rod-shaped bacterium, later identified as Nocardia otitidiscaviarum by sequencing the 16S rRNA. The patient was treated with meropenem plus rifampicin intravenously for 6 weeks followed by oral ciprofloxacin and rifampicin for 2 months. Due to pharmacokinetic interaction with rifampicin, the prednisolone dose was doubled, and the dose of tacrolimus had to be tripled for maintenance of adequate trough concentrations. Five months following cessation of antibiotic treatment, the patient has regained normal strength and function in her left-sided extremities and has a serum creatinine level of about 160 micromol/l (1.8 mg/dl).
Nephron 2000 Sep
PMID:Intracerebral abscess caused by Nocardia otitidiscaviarum in a renal transplant patient--cured by evacuation plus antibiotic therapy. 1097 Nov 57

Around 1850, Isaac L. Pulvermacher (1815-1884) joined the ranks of so-called "galvanists" who had, for nearly a century, been touting the shocks and sparks of electricity as a miracle cure for all ills, including neurological complaints such as palsy and hemiplegia. The famed authors, Gustave Flaubert (1821-1880), in France, and Charles Dickens (1812-1870), in England, although contemporaries, apparently never met or corresponded. But during their lives, they both became aware of Pulvermacher and his patented Hydro-Electric Chains, claimed to impart vigor and cure nearly every complaint. Pulvermacher's chains made a cameo appearance in Madame Bovary (1857), Flaubert's controversial (and most successful) novel. Among Dickens's last letters (1870) was an order for I. L. Pulvermacher and Company's "magic band." Since the Victorian age, electrical and magnetic cures, for better or worse, continue to be products of both the medical profession and quackery.
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PMID:Gustave Flaubert, Charles Dickens, and Isaac Pulvermacher's "magic band". 2429 Feb 67