Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0018991 (hemiplegia)
 3,997 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Paraneoplastic nephrotic syndrome (NS) in the setting of membranous nephropathy (MN) is a well-known and often prodromal complication of renal and extrarenal malignancy. Primary cerebral lymphoma is a rare neoplasm uncommonly investigated in the setting of NS. We describe for the first time a case of primary cerebral lymphoma in association with MN. An elderly woman presented for renal biopsy because an NS had been diagnosed previously and treated by steroid therapy. Primary membranous glomerulonephritis was diagnosed and immunosuppressive therapy was started. Twenty days later, she was readmitted because of left hemiplegia. Computed tomography and subsequent nuclear magnetic resonance evaluation of the brain documented an extensive cerebral space-occupying lesion. A cerebral malignant lymphoma was diagnosed at intraoperative histologic evaluation, and subsequent light microscopic and immunohistochemical studies allowed the diagnosis of peripheral T-cell lymphoma. Extensive clinical workup, including bone marrow biopsy, documented the lack of any neoplastic involvement outside the brain. Primary cerebral non-Hodgkin's lymphoma of peripheral T-cell derivation consequently was diagnosed. This case suggests that patients with MN, particularly elderly patients, should undergo complete screening for neoplasms. The absence of specific guidelines on this topic may be due partly to the lack of extensive description of all newly identified cases. All cases should be reported to evaluate whether this association is causal or fortuitous.
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PMID:Primary cerebral lymphoma and membranous nephropathy: a still unreported association. 1204 53

Moyamoya syndrome (MMS) is a rare, chronic progressive cerebrovascular occlusive disease that is characterized by a stenosis or occlusion of the bilateral internal carotid arteries and the circle of Willis arteries leading to the development of collateral vessels as visualized by cerebral angiography. We report a case of a 24-year-old woman with nephrotic syndrome whose biopsy showed membranous nephropathy. Ten months after the diagnosis she suffered sudden right hemiplegia and seizure. She was diagnosed with MMS by angiogram seven months ago and received decompressive craniotomy. The patient was admitted to our hospital and a diagnosis of systemic lupus erythematosus (SLE) was made. Glucocorticoids and tacrolimus were used to control the symptoms of SLE. Following one month of immunosuppressant treatment, the patient died of brain hemorrhage. This case alongside another six reviewed cases shows that an underlying cerebrovascular lesion of moyamoya in the vessels of patients with SLE is susceptible to cerebrovascular accidents.
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PMID:Systemic lupus erythematosus associated with Moyamoya syndrome: a case report and literature review. 2357 43

We described herein a patient who presented an overlap syndrome of childhood-onset systemic polyarteritis nodosa (c-PAN) and childhood-onset systemic lupus erythematosus (c-SLE). A 9-year-old girl presented tender subcutaneous nodules on feet, arterial hypertension, right hemiplegia and dysarthric speech. She was hospitalized due to stroke and left foot drop. Brain computer tomography showed ischemic stroke. Magnetic resonance angiography revealed stenosis in the middle cerebral and internal carotid arteries. Electroneuromyography identified a mononeuropathy of left posterior tibial nerve and she fulfilled the c-PAN validated criteria. She was treated with intravenous methylprednisolone pulse therapy followed by prednisone, that was progressively tapered, six months of intravenous cyclophosphamide and after that she received azathioprine for 19 months. At the age of 14 years and 9 months, she presented malar rash, photosensitivity, edema in lower limbs and arterial hypertension. The proteinuria was 1.7g/day. Antinuclear antibodies (ANA) were 1/1280 (homogeneous nuclear pattern) and anti-dsDNA antibodies were positive. Renal biopsy showed focal proliferative and membranous glomerulonephritis. Therefore, she fulfilled the American College of Rheumatology classification criteria for SLE and she was treated with prednisone, hydroxychloroquine and mycophenolate mofetil. In conclusion, we described herein a possible overlap syndrome of two autoimmune diseases, where c-PAN occurred five years before the c-SLE diagnosis.
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PMID:[Childhood-onset systemic polyarteritis nodosa and systemic lupus erythematosus: an overlap syndrome?] 2582 73