Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0018991 (hemiplegia)
 3,997 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Fibromuscular dysplasia (FMD) is an arterial lesion of unknown origin which may sometimes affect intracranial arteries. In recent years a few rare cases, mostly involving younger people, have been described. The present case concerns a child of 8 years in whom the finding of hemiplegia led to a diagnosis of intracranial fibrodysplasia which was proven by arteriography and biopsy. This arterial lesion is described within the context of stroke in children.
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PMID:Intracranial fibromuscular dysplasia and stroke in children. 47 Dec 30

Fibromuscular dysplasia (FMD) of the left carotid artery was diagnosed on the basis of the typical angiographic changes in a seven-year-old girl suffering from acute hemiplegia. A repeat angiography of both carotid and renal arteries 8 months later revealed no pathological changes. The diagnosis of FMD of the carotid arteries is extemely difficult and requires a biopsy or repeat angiography for verification.
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PMID:[Angiographic disappearance of fibromuscular dysplasia of the carotid artery in childhood (author's transl)]. 97 75

Fibromuscular dysplasia (FMD) is well known owing to the characteristic angiographical finding of a "string of beads" appearance, but intracranial involvement with this disease is extremely rare. Moreover, to our knowledge, only seven cases that had repeated angiograms disclosed progression of FMD lesion in the literature. Such cases of intracranial FMD which showed progression in the follow-up angiography are reported. Case 1: A 8-year-old boy was referred to our hospital because of aphasia and right hemiplegia following right hemiconvulsion. Left carotid angiography on the 7th day from the onset revealed a "string of beads" appearance involving the left middle cerebral artery from M1 to M2 portion. He was treated with low molecular dextran, urokinase and steroid. After these drugs were administered, his speech was normalized. A repeat left angiogram performed two months later disclosed definite increase in the degree of stenosis associated with FMD. Perivascular sympathectomy around common and internal carotid artery and superior cervical ganglionectomy on the left side carried out on the 70th day from the onset. Postoperative left carotid angiogram showed improvement of the stenosis markedly, and the motor disturbance was improved gradually. Case 2: A 34-year-old woman presented with head dullness and disorientation suddenly. Left carotid angiogram on the third day from the onset showed a "string of beads" appearance from C1 to M1 portion. Follow-up angiography three days later revealed some progression of the stenosis. Furthermore a repeat left angiogram disclosed occlusion of left internal carotid artery at the C2 portion. Left STA-MCA bypass surgery was performed on the 61st day from the onset.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Two cases of intracranial fibromuscular dysplasia whose repeated angiography disclosed progression of the lesion]. 332 87

Fibromuscular dysplasia of the internal carotid artery is the most frequent extracranial localization of the disease. It can produce TIA or cerebral infarct through formation of fibrinous thrombi or complete occlusion of the artery. Seven cases are presented with disease localized in the distal segment of the carotid artery, usually considered inaccessible through standard exposure. A surgical approach is described to treat these lesions by performing a mandible osteotomy. This allows a resection of the internal carotid and its replacement with autologous saphenous vein graft as performed in six cases. The distal anastomosis was performed 1 or 2 cm. below the base of the skull. One case could not be corrected due to disease extending into the skull. All patients were operated on for TIA and one had a cerebral infarct. Six patients had an uneventful recovery and no further neurological symptoms. One patient had a postoperative hemiplegia. Pathologic specimens were described as fibromuscular dysplasia in all cases. Three of them had also a dissecting aneurysm, two of these also showed a ruptured intima. Intraluminal dilatation is regarded as a potentially risky procedure; resection and replacement through a mandible osteotomy is recommended for very distal internal carotid lesions.
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PMID:Fibromuscular dysplasia of the distal cervical internal carotid artery. 727 76

A retrospective study of acute stroke diagnosed in the last ten years (20 cases: 12 girls and 8 boys) with an incidence rate of 1.26 cases per year per 100,000 inhabitants under 15 years of age) in our health area. Average age; 7.83 years (range: 2 months to 15 years). Confirming diagnosis was performed by computerised tomography (CT) scan, magnetic resonance (MR) imaging, echography and/or cerebral arteriography. Ten cases of ischaemic stroke and ten of haemorrhagic stroke were catalogued. Average follow-up was 5.45 years (range: 9 months to 10.8 years). Fibromuscular dysplasia, arthritis and meningitis are predominant in ischaemic stroke etiology, there also being one case of Moya-Moya. Haemorrhagic strokes are mostly produced by arteriovenous malformation. The predominant presenting form of ischaemic stroke was hemiplegia and of haemorrhagic strokes it was intracranial hypertension. There were no deaths as a result of ischaemic accidents but three in the cerebral haemorrhage group. Treatment was surgical in two cases, embolisation in two others and medical support in the remaining sixteen. There were no cases of relapse, except in the Moya-Moya case. Clinical position and the ability to carry on day to day life were most affected in the cerebral attack cases, which would indicate ischaemic stroke recuperation is worse than that for haemorrhagic strokes.
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PMID:[Cerebrovascular accidents in childhood]. 855 8