Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0018991 (hemiplegia)
3,997 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Between 1960 and 1983, 101 patients with congenital hemiplegia were seen at the Cerebral Palsy Center of Berne, Switzerland. During this period the numbers of right hemiplegias decreased simultaneously with the birth rate, while the left hemiplegias showed a significant increase. The known prevalence of right hemiplegias has thus disappeared in favor oft the left side (63% during the first 12.44% during the second 12 years). A continuously sinking perinatal mortality-rate during the observed time suggests an improved survival of children with lesions of the right hemisphere. This hypothesis implies a higher vulnerability of the maturing right hemisphere and could explain the earlier prevalence of right hemiplegias. Possible causes of a hemispheric asymmetry are discussed.
...
PMID:[Increasing incidence of left-sided congenital hemiplegias: indication of an asymmetrical vulnerability in the maturing hemispheres?]. 348 97

The purpose of this study was to compare and analyze changes in ambulation between two groups of children with cerebral palsy, with and without short leg casting. Sixteen children with spastic cerebral palsy, aged 10 to 108 months, were assigned randomly to either a short leg casted group or an uncasted group. All children were tested by me, before and after 10 weeks of neurodevelopmental treatment, by recording an ink print ambulation pattern on a length of paper fastened to the floor. Measurements of stride length, stride width, foot angle, and footprint clarity were taken to quantify the ambulation patterns. The percentage of improvement in stride length, stride width, and foot angle was analyzed using a t test, and the percentage of improvement in footprint clarity was analyzed using the Mann-Whitney U test. An alpha level of .05 was assumed to determine whether the differences between groups were large enough to be statistically significant. A significant difference was found in the percentages of improvement in stride length between the two groups, although the other results were nonsignificant. Short leg casting appears to be valuable in the management of spastic hemiplegia, diplegia, and quadriplegia. Clinical observations included improvement in muscle tone, trunk control, and symmetry. These results constitute the first objective measure, using a control group, supporting the therapeutic value of short leg casting for children with cerebral palsy.
...
PMID:Effect of short leg casting on ambulation in children with cerebral palsy. 353 41

A register of children with cerebral palsy born to mothers resident in the Mersey region from 1966 to 1977 was compiled from health service records. Frequency distributions and prevalences of birth weight and gestational age differed for those with hemiplegia, diplegia, and quadriplegia. In particular, the children with diplegia showed a bimodal frequency distribution. Children of normal birth weight with diplegia had a higher prevalence of severe mental retardation than those of low birth weight. These differences may be due to survival bias and may not be of aetiological importance. Furthermore, the mothers of diplegic infants had a significantly higher proportion of spontaneous abortions, stillbirths, and low birthweight infants in their obstetric history. This suggests that prenatal factors predominate in the aetiology of diplegia.
...
PMID:Effects of birth weight, gestational age, and maternal obstetric history on birth prevalence of cerebral palsy. 367 22

The purpose of this study was to analyze retrospectively which neuromotor behaviors in a sample of four-month-old low-birthweight infants were most predictive of later cerebral palsy. The infants were evaluated at four months corrected age on the Movement Assessment of Infants (MAI) and were followed to between three and eight years of age. For the CP group as a whole, 17 neuromotor items from the MAI were highly significant (p less than 0.001) predictors of cerebral palsy. A further 15 items also were significant, but less highly so (p less than 0.01 to p less than 0.05). Seven items were predictive of later spastic diplegia, seven of spastic hemiplegia, and 35 items differentiated quadriplegic infants. A shorter version of the MAI should be developed to increase its over-all reliability and validity in the early detection of cerebral palsy. Only then would it be possible to implement early therapeutic intervention and to evaluate its efficacy.
...
PMID:Early neuromotor predictors of cerebral palsy in low-birthweight infants. 367 30

Four homogeneous patterns of gait were defined in forty-six patients who had spastic hemiplegia secondary to cerebral palsy or other neurological disorders by analyzing kinematic data in the sagittal plane and electromyographic data. In Group I (twenty patients) the primary abnormality was a drop foot in the swing phase. The thirteen patients in Group II had a tight heel cord in the stance phase as well as a drop foot in the swing phase. The five patients in Group III also had more proximal involvement (that is, restricted motion of the knee) as well as an equinus deformity of the ankle. In Group IV, the eight patients had, in addition, restricted motion of the hip.
...
PMID:Gait patterns in spastic hemiplegia in children and young adults. 381 6

Among 2100 children with a diagnosis of cerebral palsy (CP) twenty carried the diagnosis: Previous CP, now normalized. Seventeen patients could be traced and were reevaluated. Cerebral palsy was diagnosed in these seventeen children (ten boys, seven girls) between the ages of three months and three years (average eleven months). They were found to be normal when reexamined between the ages of one year and five years (average two years two months). Two patients had tetraplegia, three diplegia, nine paraplegia ("paraplegia" were cases of diplegia with minimal affection of the upper limbs - now called "diplegia type I"), and one hemiplegia. One patient had atactic diplegia, and one was athetotic. The records of these seventeen patients were evaluated with respect to aetiology and symptomatology. Upon reexamination seven patients were found to be completely normal. Five patients had no motor symptoms but showed signs of specific neuropsychological difficulties. Two patients were intellectually retarded without motor symptoms. One showed signs of neuropathy, and one had fetal alcohol syndrome. Signs consistent with CP could be demonstrated in one patient only. This study shows that signs of CP may in rare cases disappear altogether.
...
PMID:Spontaneous remission of cerebral palsy. 396 Feb 79

This study was undertaken to evaluate tendon transfers in a group of children with spastic hemiplegia. Muscle grading, video recordings of function, and electromyographs were performed on 12 patients preoperatively. Postoperative electromyograms were obtained on 16 transferred tendons in eight patients as the children performed assigned tasks. Clinical evaluation demonstrated improvement in all patients at follow-up, which averaged 20 months. Four of the 16 muscles showed changes in their electrical activity postoperatively. Three muscles that fired continuously became phasic, and one muscle changed phase to match its recipient. Pre- and postoperative electromyography with video analysis provided a more complete understanding of the characteristics of tendon function with tendon transfers in cerebral palsy.
...
PMID:Upper extremity tendon transfers in cerebral palsy: electromyographic and functional analysis. 398 Jul 10

Twenty-one children born 1970-76, selected from 103 children of 30 alcoholic women, were paired to controls matched for sex, age, birth weight and gestational age. The sample (10 girls, 11 boys) was representative of the whole group with regard to weight, length and head circumference at birth. At follow-up (mean age 70 months) the study group was significantly leaner, shorter and had smaller mean head circumference than the control group. The controls had significant catch-up growth from birth to follow-up of weight, height and head circumference to the mean for Swedish children. The study group had no catch-up growth. Compared to controls the study group had significantly lower fine and gross motor age test scores and inferior coordination. One child had cerebral palsy (spastic hemiplegia) and in 6 other children slight tremor and ataxia were observed. Malformations and/or other signs of the fetal alcohol syndrome (FAS) were found in 10 cases. Study group children with FAS had significantly slower growth of head circumference than others without FAS. Children placed in foster home care (n = 11) were found to have significantly (p less than 0.05) lower birth weight, birth length and head circumference than children raised at home (n = 10). There were no significant differences at follow up between study group children raised in foster homes or in homes of their biological mother.
...
PMID:Children of alcoholic mothers. Growth and motor performance compared to matched controls. 398 23

We have studied the natural history of spontaneous dislocation of the hip in cerebral palsy, with particular reference to the pattern of neurological involvement. In patients with bilateral hemiplegia and severe involvement of the upper limbs the incidence of dislocation was very high (59%), while in those with diplegia and little involvement of the upper limbs, only 6.5% were affected. There was no evidence of dysplasia or instability of the hip in any of the patients with unilateral hemiplegia. A strong correlation was found between the stability of the hip and the patients' ability to walk. These findings have a bearing on clinical surveillance and also on the indications for prophylactic surgery.
...
PMID:Factors affecting the incidence of hip dislocation in cerebral palsy. 403 Aug 44

After the introduction of cranial computed tomography (CT) it is now possible by an atraumatic procedure to evaluate the pathophysiological findings in children suffering from cerebral palsy (CP). The aim of this study is to describe the cranial CT findings in children with CP and relate these to CP-type, grade of handicap, aetiology, and presence of other functional cerebral defects. The CT-examination was performed in 83 children with spastic CP (44 boys and 39 girls). Fifty-seven children (67%) had pathological CT. There was no statistically significant difference between the frequencies of pathological CT findings in the groups with tetraplegia, diplegia, and paraplegia. The frequency of pathological CT findings was increasing with increasing severity of the motor handicap (p less than 0.05). There were significantly more children with pathological CT findings among CP children suffering from epilepsy, than among CP children without epilepsy (p less than 0.05). The CP children with the lowest IQ, had numerical more pathological CT findings but there was no significant difference among pathological CT findings in CP children with oligophrenia compared to the rest of the group. Infarction, its sequelae and hemiatrophy were much more frequent in patients with hemiplegia (p less than 0.001) compared to the other CP-types. The most frequent pathological CT finding was atrophy (44 cases among 56 pathological CT). Central atrophy with enlargement of the ventricular system or parts of this was found in 39 children.(ABSTRACT TRUNCATED AT 250 WORDS)
...
PMID:CT findings in spastic cerebral palsy. Clinical, aetiological and prognostic aspects. 648 9


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>