Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0018991 (hemiplegia)
 3,997 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 65-year-old female with bilateral renal cell carcinoma which was incidentally found by general check-up developed left hemiplegia following left nephrectomy. Marked metastasis of cervical spine was demonstrated by computerized tomography scanning, which was not evident before the operation by X-ray examinations. The patient died of respiratory paralysis one month after the operation. This case was difficult to treat, because the disease advanced so rapidly.
 ...
PMID:[Synchronous bilateral renal cell carcinoma in mass examination: a case report]. 836 85

We encountered a case of multiple metastatic brain tumors with simultaneous multiple cerebral hemorrhages. A 45-year-old male suffered from sudden left hemiplegia and was admitted to our hospital. CT scans on admission revealed multiple cerebral hemorrhages with surrounding brain edema in the right frontal lobe, left frontal lobe, right occipital lobe and right basal ganglia. On full-body examination, renal cell carcinoma of the left kidney and multiple metastatic tumors in the lung, liver and vertebral body were identified. We continued conservative therapy, but the patient's condition worsened and he died 36 days later. The autopsy findings indicated that all hemorrhages had occurred in the necrotic tissue associated with the metastatic brain tumors. Simultaneous multiple cerebral hemorrhages caused by metastatic brain tumors are very rare, and the differential diagnosis of cerebral hemorrhage due to metastatic brain tumor and hypertensive cerebral hemorrhage is difficult. The present case indicates that metastatic brain tumor should be taken into consideration in cases with simultaneous multiple intracerebral hemorrhages.
 ...
PMID:[Metastatic brain tumors with simultaneous multiple cerebral hemorrhages: a case report]. 2151 97

A 59-year-old man underwent radical nephrectomy for left renal cell carcinoma with multiple lung metastases (cT3bN0M1) in May 2010. Pathological diagnosis was clear cell carcinoma, G2 and pT3b. After sunitinib treatment for 7 months computed tomography (CT) revealed complete response of lung lesions and the treatment was continued. After 10 months, the patient complained of right hemiplegia. Brain magnetic resonance imaging (MRI) revealed a 3 cm tumor in his frontal lobe of cerebrum. He underwent surgical resection of the tumor and pathological diagnosis was metastatic renal cell carcinoma. He has been well without local recurrence or distant metastasis for 18 months.
...
PMID:[Brain metastasis which appeared during complete response of lung metastatic lesion by sunitinib treatment in a patient with renal cell carcinoma]. 2441 11

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL) is one of the most common heritable causes of stroke and dementia in adults. The gene involved in the pathogenesis of CADASIL is Notch3; in which mutations affect the number of cysteine residues in its extracellular domain, causing its accumulation in small arteries and arterioles of the affected individuals. Besides the usual neurological and vascular findings that have been well-documented in CADASIL patients, this paper additionally reports multiple neoplastic lesions that were observed in an autopsy case of CADASIL patient; that could be related to Notch3 mutation. The patient was a 62 years old male, presented with a past history of neurological manifestations, including gait disturbance and frequent convulsive attacks. He was diagnosed as CADASIL syndrome with Notch3 Arg133Cys mutation. He eventually developed hemiplegia and died of systemic convulsions. Autopsy examination revealed-besides the vascular and neurological lesions characteristic of CADASIL- multiple neoplastic lesions in the body; carcinoid tumorlet and diffuse idiopathic pulmonary neuro-endocrine cell hyperplasia (DIPNECH) in the lungs, renal cell carcinoma (RCC), prostatic adenocarcinoma (ADC) and adenomatoid tumor of the epididymis. This report describes a spectrum of neoplastic lesions that were found in a case of CADASIL patient that could be related to Notch3 gene mutations.
...
PMID:Neoplastic lesions in CADASIL syndrome: report of an autopsied Japanese case. 2626 65