Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0018991 (hemiplegia)
 3,997 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A single case study of a 33-year-old right-handed man who suddenly developed left hemiplegia and nonfluent aphasia is reported. Extensive testing of the patient's reading ability revealed the symptom complex of deep dyslexia. The relevance of crossed deep dyslexia in a reader of Italian is discussed.
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PMID:Deep dyslexia in a patient with crossed aphasia. 672 18

Fabry's disease is a rare familial disorder of glycolipid metabolism which is caused by a deficiency of a lysosomal enzyme alpha-galactosidase. A Finnish family is described in which cornea verticillata was found in the father and 2 daughters. In all cases, there were symptoms suggesting Fabry's disease: febrile episodes the origin of which was not clear, limb pains and, in the case of the father, 20 years of proteinuria with elevated ESR, and hemiplegia and aphasia following a cerebral thrombosis at the age of 43. The diagnosis was confirmed by demonstration of an alpha-galactosidase deficit in the serum and urine of all patients. Deficiency of this enzyme leads to abnormally high urinary tri- and dihexosyl ceramide levels, and this was observed in the father and the elder daughter. At the age of 12, the daughter had loss of vision in her right eye as a result of occlusion of the central retinal artery. Electron microscopic (EM) examination of the father's dermal angioma suggested Fabry's disease. Computerized cranial tomography of the father revealed not only the cerebrovascular condition but also a disease affecting the white matter of the brain.
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PMID:Fabry's disease and cornea verticillata. A report of 3 cases. 679 29

The performance of five aphasics with agraphia and right hemiplegia showing side differences in writing to dictation is reported on. It was found that writing with the paralyzed arm, supported by a writing aid, was better than writing with the left hand. In a control group of aphasics with agraphia, but without hemiplegia, such side differences were not found. The conclusion is drawn that in aphasia with hemiplegia the lesions intersect the path between the graphic region of the dominant hemisphere and the corpus callosum. Therefore the observed syndrome is termed "Graphic Disconnection Syndrome."
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PMID:Side differences in writing to dictation of aphasics with agraphia: a Graphic Disconnection Syndrome. 683 27

A 64-year-old man was admitted with complaints of lethargy, malaise, weight loss and transient left-hemiplegia and aphasia. Initial physical and laboratory findings showed splenomegaly and pericardial effusion. During his hospital stay, his mental status deteriorated progressively. The characteristic pathology of malignant reticulosis was noted at autopsy. Microscopic examination of the brain demonstrated accumulations of malignant histiocytic cells confined within small vessels and subsequent multiple hemorrhages and necroses in the gray matter. Malignant reticulosis with antemortem manifestations of pericardial effusion and central nervous system involvement is rare.
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PMID:[A case of malignant reticulosis with pericardial effusion and central nervous system involvement]. 685 69

Ventriculitis developed suddenly in a patient with an undiagnosed abscess and was accompanied by obtundation, fever, meningismus, and hemiplegia. Aspiration of a streptococcal thalamic abscess and high doses of intravenous penicillin produced marked improvement. Increasing dysphasia 5 weeks later was accompanied by ventricular dilatation, most marked on the left, with no evidence of recurrent abscess. The left foramen of Monro was demonstrably patent. Shunting relieved the symptoms of aphasia; they recurred with one episode of malfunction of the shunt. This case lends support to the belief that parenchymal characteristics are important in hydrocephalus and demonstrates how asymmetrical ventricular dilatation can produce focal symptoms.
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PMID:Asymmetrical hydrocephalus following ventriculitis from rupture of a thalamic abscess. 685 81

Two patients with agrammatic speech and unimpaired comprehension are presented and contrasted. Case 1 had an infarction involving precentral gyrus, subjacent white matter, and posterior and superior aspects of the insula, largely sparing Broca's area. His speech was slow and dysarthric, consisting of short disconnected phrases with some omission of lexical verbs. Case 2 had an unusual transient aphasia of acute onset without hemiplegia; speech rate, articulation, and sentence length and complexity appeared normal. Both patients tended to omit function words and finite verb inflections, but Case 2 did so much more than did Case 1. Neither patient showed impairment in any other area of language performance. Tentatively, Case 2 is described as being more morphologically impaired but less syntactically impaired than Case 1, while neither has damage to a central language processor.
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PMID:Contrasting cases of Italian agrammatic aphasia without comprehension disorder. 686 Sep 36

Nine cases of subcortical aphasia with capsular/putaminal (C/P) lesion sites demonstrated on computed tomographic (CT) scans were studied. Eight cases were occlusive-vascular in etiology and one was hemorrhagic. Three subcortical aphasia syndromes and three C/P lesion site patterns were observed. Patients with C/P lesion sites with anterior-superior white-matter lesion extension had good comprehension, grammatical, but slow, dysarthric speech, and lasting right hemiplegia. Patients with C/P lesion sites with posterior white-matter lesion extension across the auditory radiations in the temporal isthmus had poor comprehension, fluent Wernicke-type speech, and lasting right hemiplegia. Patients with C/P lesion sites with both anterior-superior and posterior extension were globally aphasic and had lasting right hemiplegia. Although these cases of C/P subcortical aphasia shared certain well-known features of Broca's and Wernicke's cortical aphasia syndromes, they did not completely resemble cases of either Broca's, Wernicke's, global, or thalamic aphasia in neurologic findings, CT scan lesion sites, or language behavior. Further study of the subcortical aphasias associated with these C/P lesion sites seems to be warranted.
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PMID:Aphasia with predominantly subcortical lesion sites: description of three capsular/putaminal aphasia syndromes. 697 80

The possibility of aphasic disorder caused by thalamic lesions has been supported by anatomo-clinical findings, stereotaxic surgery and more recently by radiological investigations with new techniques, i.e. ct and brain scan. A case of thalamic aphasia investigated with these techniques and the Luria's neuropsychological test is reported in this paper. The case concerns a 50 years old woman who developed a sudden right hemiplegia with marked motor aphasia. C.T. and radioisotope brain scan revealed a left capsular haemorrhage with involvement of thalamic structures. Later, when this patient's aphasia decreased, Luria's test showed reduction of spontaneous speech, anomia, paraphasic and disarthric disorder, distractibility without impairment of comprehension and repitition. These findings are similar to those reported by some AA. in left thalamic lesions and similar to aphasic syndromes caused by cortical lesions. Another important observation was the presence of widespread cortical functional disorder involving the left fronto-temporo-parietal region without evidence of cortical anatomical alteration. The above data and those reported in the literature suggest a very close relationship between thalamic structures, other central nuclei and cortical areas particularly in the control of speech.
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PMID:[On a case of aphasia with thalamic lesion (author's transl)]. 703 35

A 19-year-old white man developed aphasia and right hemiplegia after several falls while waterskiing. Cerebral angiography displayed a ripple appearance and a "string of beads" sign along the left middle cerebral artery, with occlusion or stenosis of most of its branches. The patient died after 6 days, of transtentorial herniation due to massive left cerebral infarction. At necropsy, the infarct was found to be due to a subintimal dissecting aneurysm of the left middle cerebral artery. Multifocal areas of intimal fibroelastic thickening (IFT) were found not only at the site of dissection, but also in the other cerebral arteries, most prominent at the bifurcations of the vessels. A systematic study of cerebral arteries performed in six control cases revealed that IFT was present in a similar distribution to that seen in the patient described. However, the degree of IFT in this patient was greater than in the controls. Some individuals with excessive IFT may be more susceptible to cerebral dissecting aneurysm under a variety of stresses, especially trauma.
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PMID:Cerebral dissecting aneurysm and intimal fibroelastic thickening of cerebral arteries. Case report. 706 29

A 61-year-old and right handed man was admitted to our department on August 11, 1980. The patient had three month history of focal fits, progressive hemiplegia, and motor dominant aphasia. The neuroradiological examination revealed a space taking lesion at the left frontoparietal area, which showed a small tumor stain with early filled draining vein on the left carotid angiogram, and iso-high dense mass with marked contrast enhancement on the CT scan. The EEG findings showed polymorphous delta rhythm in the left frontal and parietal areas. On August 28, total removal of the tumor was performed. The tumor was a intracerebral, fibrous cystic mass without involvement of the pia and dura mater. The removed tumor was measured approximately 6 X 5 X 4 cm in size, and consistence of the tumor was mostly elastic hard and partially soft and hemorrhagic. Histologically, the tumor composed of an admixture of bizarre histiocytes and fibroblasts, multinucleated giant cells, xanthoma cells and siderophages, with fibrous stroma. After surgery, no distinct lesion was demonstrated on the whole body CT scan and garium and technetium scintigram in the abdomen and the lung. The right hemiplegia and aphasia were improved gradually, and the patient discharged on December 20, 1980. We discussed the origin of this tumor, and angiographic and CT scan findings on the literature.
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PMID:[Intracerebral fibrous xanthosarcoma--report of a case]. 717 24


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