Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0018801 (heart failure)
 72,216 document(s) hit in 31,850,051 MEDLINE articles (0.05 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Sep 4523
renin 2521
natriuretic peptide 2465
Mol 2334
angiotensin II 1501
insulin 1206
ACE 1164
collagen 1045
She 826
angiotensin receptor 792
Mal 767
ATP 729
cytokine 725
atrial natriuretic peptide 650
Ang II 641
BNP 624
ATPase 623
cardiac muscle 599
hemoglobin 547
phosphodiesterase 508
mineralocorticoid receptor 498
calcium channel 481
vasopressin 474
neutral endopeptidase 431
tumor necrosis factor 412
C-reactive protein 402
Pol 378
MRI 372
myosin 368
angiotensin II receptor 357
atrial natriuretic factor 331
phospholamban 326
albumin 312
TNF 309
endothelin-1 295
nitric oxide synthase 283
creatine kinase 276
chronic renal failure 267
IL-6 263
Angiotensin-converting enzyme 251
ryanodine receptor 251
endoplasmic reticulum 250
bradykinin 244
calcineurin 243
caspase-3 235
beta 1 234
ICD 233
AT1 229
sarcomeric 228
ANP 223
p38 210
myosin heavy chain 208
troponin I 199
interleukin-6 194
superoxide dismutase 193
erythropoietin 191
Bcl-2 190
RyR2 188
calmodulin 187
gut 186
matrix metalloproteinase 183
galectin-3 183
vascular endothelial growth factor 182
thyroid hormone 175
reserved 173
ERK1 169
glucagon 164
transthyretin 163
adenylyl cyclase 161
arginine vasopressin 157
Renin 157
TNF-alpha 157
COPD 157
peptidase 153
AMP 151
growth hormone 151
p53 150
histone 149
mTOR 146
MAPK 146
ROS 145
proteasome 142
ferritin 142
nodal 134
ubiquitin 134
dystrophin 130
adiponectin 130
ADP 130
cardiac troponin I 128
ERK 128
AKT 128
troponin T 128
lactate dehydrogenase 125
vascular endothelium 125
CRT 125
adenylate cyclase 123
endothelial nitric oxide synthase 123
CO2 121
G protein-coupled receptor 120
endothelin receptor 119
PI3K 119
PKA 118
titin 116
peroxisome proliferator-activated receptor 115
ET-1 115
inducible nitric oxide synthase 114
MHC 114
CaMKII 113
sodium-glucose cotransporter 108
CRP 107
GLP-1 receptor 107
fibrinogen 107
adrenomedullin 105
apelin 105
serum albumin 104
catalase 104
X-linked 104
cardiac troponin T 103
Gen 102
ANG 101
VEGF 100
guanylate cyclase 98
xanthine oxidase 98
relaxin 97
phosphatase 96
NMR 96
angiotensinogen 96
HDL 94
glutathione peroxidase 94
JNK 93
tyrosine kinase 93
leptin 93
fibronectin 92
desmin 92
MMP-2 91
IL-10 91
ST2 91
eNOS 90
SERCA2 90
CD4 90
REG 89
AMP-activated protein kinase 89
MMP-9 88
Rho 88
glycoprotein 88
SARS 86
ARB 85
PKC 85
insulin-like growth factor 84
NAD 82
threonine 82
interferon 82
polypeptide 82
IL-1 81
calcium pump 81
GRK2 80
ghrelin 79
alpha-MHC 79
metalloproteinase 78
cytochrome c 78
more...
Disease
heart failure 72216
hypertension 8321
myocardial infarction 6961
diabetes 4722
congestive heart failure 4712
stroke 4603
cardiomyopathy 4298
cardiovascular disease 3361
heart disease 3221
coronary artery disease 2951
dilated cardiomyopathy 2738
myocardial ischemia 2676
acute myocardial infarction 2469
ischemia 2040
cancer 1999
atherosclerosis 1677
pulmonary hypertension 1515
obesity 1483
ventricular hypertrophy 1461
myocarditis 1315
coronary heart disease 1230
renal failure 1186
mitral regurgitation 1185
depression 1115
anemia 1056
type 2 diabetes 1000
renal disease 960
endocarditis 928
tumor 886
chronic obstructive pulmonary disease 881
hypertrophic cardiomyopathy 817
sepsis 799
sepsis 731
pulmonary edema 719
aortic stenosis 663
pneumonia 654
ischemic cardiomyopathy 577
idiopathic dilated cardiomyopathy 543
aortic regurgitation 538
ventricular fibrillation 537
cirrhosis 501
pulmonary embolism 470
right heart failure 463
left ventricular failure 462
amyloidosis 461
respiratory failure 443
sleep apnea 443
valvular heart disease 438
diabetic cardiomyopathy 429
pericarditis 419
chronic renal failure 399
metabolic syndrome 394
atrioventricular block 392
renal insufficiency 377
left bundle branch block 371
asthma 371
vascular disease 369
ventricular dilatation 366
essential hypertension 347
unstable angina 345
ventricular septal defect 338
tricuspid regurgitation 336
obstructive sleep apnea 329
pericardial effusion 322
dyslipidemia 318
chronic disease 304
Chronic heart failure 295
myopathy 294
hyperlipidemia 294
hyperglycemia 293
dementia 287
Chagas 277
proteinuria 277
malnutrition 274
fluid overload 271
renal impairment 270
breast cancer 248
plaque 244
hypertensive heart disease 238
liver disease 237
ATM 235
ICD 234
hypothyroidism 231
hyperthyroidism 231
mitral stenosis 231
cognitive impairment 228
restrictive cardiomyopathy 227
acute renal failure 225
flutter 224
rheumatoid arthritis 222
hypercholesterolemia 218
heart block 216
diabetic nephropathy 214
lung disease 204
atrial septal defect 195
hypoglycemia 193
Peripartum cardiomyopathy 193
sarcoidosis 191
lymphoma 191
Duchenne muscular dystrophy 190
iron deficiency 187
systemic lupus erythematosus 187
Alzheimer's disease 185
infectious diseases 185
Hypertrophic cardiomyopathy 177
muscular atrophy 177
thrombocytopenia 176
peripheral vascular disease 175
rheumatic heart disease 172
dysplasia 171
HIV 169
virus infection 169
carcinoma 169
cold 168
metastases 168
acute myocarditis 165
iron overload 165
cardiac tamponade 164
tuberculosis 163
SEM 158
COPD 157
bacterial endocarditis 149
supraventricular tachycardia 146
transient ischemic attack 145
cor pulmonale 143
preeclampsia 142
multiple myeloma 141
vasculitis 141
osteoporosis 137
Acute heart failure 137
Fibrillation 136
acute pulmonary edema 135
rare disease 132
systolic hypertension 130
arthritis 129
idiopathic cardiomyopathy 125
muscular dystrophy 123
SARS 123
lung cancer 121
wasting 118
leukemia 117
thalassemia 117
influenza 117
sympathomimetic 116
idiopathic thrombocytopenic purpura 116
epilepsy 114
aldosteronism 111
thyrotoxicosis 110
West 110
lactic acidosis 109
hemangioma 109
hepatitis 108
pheochromocytoma 108
cerebral infarction 107
coagulopathy 107
AIDS 107
eosinophilia 106
Edwards 105
coma 104
arteriosclerosis 104
more...
Symptom
dyspnea 1779
angina 1539
fatigue 735
chest pain 574
anesthesia 558
regurgitation 558
pain 525
syncope 445
weakness 368
respiratory distress 320
cachexia 296
cough 289
shortness of breath 269
cyanosis 228
collapse 228
exertional dyspnea 201
headache 199
overweight 183
seizures 168
diarrhea 164
vomiting 153
dizziness 150
hypothermia 146
CSR 143
hepatomegaly 140
nausea 134
thinning 133
abdominal pain 128
functional recovery 125
anorexia 119
discomfort 110
discomfort 102
orthopnea 101
hypercapnia 100
sleepiness 98
rales 89
exhaustion 85
starvation 69
hemoptysis 67
Ill 65
spasm 64
tachypnea 64
leg edema 59
splenomegaly 53
oliguria 50
insomnia 46
hypotonia 45
constipation 44
lethargy 44
snoring 43
arthralgia 43
back pain 42
flushing 39
myalgia 39
nausea and vomiting 39
hepatosplenomegaly 38
Exercise intolerance 38
analgesia 36
agitation 36
tremor 35
hypocapnia 32
ataxia 32
exertional angina 31
asynergy 30
vertigo 30
erythema 26
polyuria 25
hypoproteinemia 24
acute stress 24
presyncope 23
low back pain 23
pallor 22
atypical chest pain 22
chills 21
paresis 21
hemiplegia 20
hyperoxia 19
wheezing 19
asthenia 18
Depressive symptoms 17
epigastric pain 17
numbness 16
paresthesia 15
intestinal bleeding 15
tinnitus 15
fever of unknown origin 14
decreased appetite 14
polydipsia 13
twitching 13
sinus pressure 13
bone pain 13
productive cough 13
muscle stiffness 12
precordial pain 12
chronic cough 11
dysarthria 11
Acute dyspnea 11
consciousness disturbance 11
Periodic breathing 10
acute abdomen 10
clubbing 10
lightheadedness 10
chest tightness 10
dystonia 10
muscle cramps 10
pedal edema 10
ophthalmoplegia 9
urinary frequency 9
pleuritic chest pain 9
S3 gallop 9
abdominal discomfort 8
sore throat 8
syncopal episodes 8
colic 8
forgetfulness 7
apathy 7
cerebellar ataxia 7
blurred vision 7
tense 7
abnormal breathing 7
memory loss 7
Multimorbidity 7
acute pain 7
acidity 6
persistent cough 6
right upper quadrant pain 6
cardiovascular impairment 6
hoarseness 6
exertional chest pain 6
hunger 6
leg pain 6
stigma 6
bigeminal 6
prostration 6
chorea 6
hypertonia 6
ENT 6
enuresis 6
joint stiffness 5
tonic-clonic seizure 5
flank pain 5
heartburn 5
eds 5
emaciation 5
muscle rigidity 5
myoclonus 5
Decreased activity 4
acute abdominal pain 4
giddiness 4
hypersomnia 4
giddiness 4
anosmia 4
labored breathing 4
Cardiovascular symptoms 4
Neurologic symptoms 4
diastolic murmurs 4
Gastrointestinal symptoms 4
hopelessness 4
rigors 4
night sweats 3
more...
Drug
Cardiovasc 5111
nitroglycerin 290
Angiotensin II 241
Monit 176
Levosimendan 166
Digitalis 149
ROS 145
Captopril 143
Dial 142
Nephron 106
caffeine 104
ROC 101
Valsartan 92
Nesiritide 87
lysine 83
Tolvaptan 81
Fraction 71
NADH 68
Ramipril 66
MAP 64
Dermatol 62
ETA 52
ICI 51
Spectrum 51
Perindopril 51
vitamin E 47
ascorbate 46
Adriamycin 46
Herceptin 43
Nebivolol 42
Enoximone 41
Amrinone 40
CSF 40
AHF 39
Dronedarone 36
Glucagon 33
Ranolazine 32
Ranolazine 32
Ibopamine 32
TAC 31
Nephron 31
Aliskiren 30
IL-2 30
Growth hormone 29
Growth hormone 29
Flosequinan 29
Ouabain 27
Omapatrilat 26
Nitric Oxide 26
Vesnarinone 25
Dakar 24
ampicillin 22
CTX 22
ADM 22
Pimobendan 22
Propofol 21
Rosuvastatin 20
Rosiglitazone 20
Clopidogrel 19
Torasemide 19
Sodium nitroprusside 18
EPI 18
Ethanol 18
PTH 17
APD 17
Simvastatin 16
Bosentan 16
Bosentan 16
Conivaptan 15
Atenolol 15
Liraglutide 15
Serum albumin 15
G-CSF 15
Vitamin E 15
Gel 14
Asthma 14
Ginseng 14
citric acid 14
Indomethacin 13
Albumin 13
Heme 13
BH4 12
ENT 12
Epoetin 12
RFP 12
Felodipine 12
Dopexamine 12
CaCl2 12
IFN-gamma 12
Trandolapril 11
Imatinib 11
uPA 11
Leaf 11
CaCl2 11
Dexrazoxane 11
niacin 11
Carperitide 11
Bortezomib 11
Parkin 11
CaCl2 11
Parkin 11
Bevacizumab 11
ADR 10
CPR 10
TAT 10
Clonidine 10
Darbepoetin alfa 10
Adenosine triphosphate 10
MgSO4 10
DM1 10
Prednisolone 10
Molsidomine 10
Theophylline 9
Vitamin K 9
Forskolin 9
Fenoldopam 9
Bayer 9
TAK 9
Viagra 9
Inspra 9
Atropine 8
Timolol 8
Enalaprilat 8
Streptokinase 8
CTA 8
Triclosan 8
Infliximab 8
Spectrum 8
CIA 8
Viagra 8
Salbutamol 8
Fluorescein 8
Anakinra 8
CVA 8
PCP 8
Activin 8
Infliximab 8
Ringer's solution 8
ABC 8
IL-1ra 8
EMB 8
Enalaprilat 8
Dopexamine hydrochloride 8
Coral 7
Olmesartan 7
Lixivaptan 7
Amiloride 7
Itraconazole 7
Portal 7
Denopamine 6
EE2 6
MRC 6
Cordarone 6
Alliance 6
EPA 6
Tacrolimus 6
Methylprednisolone 6
Sorafenib 6
Phentolamine 6
K201 6
more...
Enzyme
renin 2521
ACE 1848
ATPase 676
protein kinase 673
mitogen-activated protein kinase 525
phosphodiesterase 509
CD10 456
creatine kinase 362
ERK 303
calcineurin 261
superoxide dismutase 238
protein kinase C 220
NADPH oxidase 197
caspase-3 177
NO synthase 164
AMP-activated protein kinase 155
NADPH oxidase 152
proteasome 147
lactate dehydrogenase 144
guanylate cyclase 139
adenylate cyclase 132
catalase 123
luciferase 117
CaMKII 109
GRK2 103
xanthine oxidase 103
AMPK 100
GRK5 98
focal adhesion kinase 95
glutathione peroxidase 94
peroxidase 82
ACS 76
thrombin 74
AMPK 71
complex I 68
PDE 68
aspartate aminotransferase 66
MEK 65
PKG 63
tissue plasminogen activator 63
NOS 61
alkaline phosphatase 60
MAP 59
CAD 58
CAD 58
CAD 58
collagenase 57
alanine aminotransferase 56
phosphoinositide 3-kinase 55
thromboplastin 52
citrate synthase 48
pyruvate dehydrogenase 47
reverse transcriptase 47
GSK 47
PARP 45
APC 45
acetylcholinesterase 41
urokinase-type plasminogen activator 41
phosphatidylinositol 3-kinase 41
tyrosine hydroxylase 39
pyruvate dehydrogenase 38
angiotensin-converting enzyme 2 38
pyruvate dehydrogenase 38
succinate dehydrogenase 37
calcium pump 37
glyceraldehyde-3-phosphate dehydrogenase 37
CPT 36
kallikrein 36
chymase 35
caspase-1 34
endothelin-converting enzyme 32
PDK1 31
aldehyde dehydrogenase 30
myosin ATPase 30
phospholipase C 30
cytochrome oxidase 29
MMP 28
caspase-8 28
ATP synthase 25
acyl-CoA dehydrogenase 25
alcohol dehydrogenase 24
RNase 24
RNase 24
phospholipase A2 23
lysyl oxidase 22
alpha-galactosidase 22
trypsin 22
glyceraldehyde-3-phosphate dehydrogenase 22
aequorin 21
PRA 21
CPT 21
beta-galactosidase 21
CPT 21
alpha-glucosidase 21
furin 21
cholinesterase 20
P-glycoprotein 20
RNA polymerase 20
caspase-9 20
aldehyde dehydrogenase 19
aldehyde dehydrogenase 19
aldehyde dehydrogenase 19
aldehyde dehydrogenase 19
ADH 19
glyceraldehyde-3-phosphate dehydrogenase 18
monoamine oxidase 18
heme oxygenase 18
gamma-glutamyl transpeptidase 18
soluble epoxide hydrolase 17
glyceraldehyde-3-phosphate dehydrogenase 17
glutathione reductase 17
diaphorase 17
glyceraldehyde-3-phosphate dehydrogenase 17
AST 17
CYP3A4 17
PAH 17
carbonic anhydrase 16
IKK 16
glutathione S-transferase 16
NADPH-diaphorase 15
ceruloplasmin 15
lipoprotein lipase 15
xanthine dehydrogenase 15
glucose-6-phosphate dehydrogenase 15
CPR 14
3-hydroxy-3-methylglutaryl coenzyme A reductase 14
MMP-3 14
neuraminidase 14
MIP 13
plasmin 13
CCS 13
pyruvate kinase 13
matrix metalloproteinase 2 13
myosin light chain kinase 13
protein phosphatase 2A 12
topoisomerase 12
topoisomerase 12
histone acetyltransferase 12
NQO1 11
tryptase 11
lipoxygenase 11
DNase 11
MEKK1 11
MCS 11
phosphorylase 11
dihydropyrimidine dehydrogenase 10
choline acetyltransferase 10
peroxiredoxin 10
AMP deaminase 10
adenosine deaminase 10
adenosine deaminase 10
TAT 10
phosphofructokinase 9
mu-calpain 9
diaphorase 9
O-GlcNAc transferase 9
cathepsin D 9
arginase 9
branching enzyme 9
acyl-CoA dehydrogenase 9
more...
Compound
Cardiol 9993
Clin 5303
Dec 4878
oxygen 3400
calcium 3020
sodium 2225
aldosterone 2085
glucose 1514
acetate 1287
nitric oxide 1160
water 1129
creatinine 1002
potassium 942
DNA 809
ATP 730
salt 676
BNP 611
Angiotensin II 566
iron 563
His 446
CO2 423
cAMP 393
noradrenaline 389
Ang II 354
phosphate 351
arginine 328
cGMP 326
TNF 309
urea 259
nitrogen 228
Digoxin 222
nitrate 210
Carvedilol 204
serine 176
hydrogen 172
Sodium 163
AMP 162
Optimal 158
ADP 153
GMP 153
Adriamycin 151
tyrosine 150
Dial 145
vitamin D 144
Amiodarone 141
Insulin 141
ADP 134
ADP 130
ethanol 129
phosphocreatine 128
iodine 128
Isoproterenol 124
Spironolactone 120
ADR 119
cysteine 119
threonine 116
ASA 115
Hearts 114
Hearts 111
Dobutamine 110
prostacyclin 110
Thyroid 109
lysine 104
caffeine 104
NAD 98
Enalapril 96
Losartan 93
sulfate 93
coenzyme Q10 92
DCM 92
AHA 90
Metoprolol 89
homocysteine 87
Eplerenone 85
Pac 84
zinc 83
Metoprolol 83
NAD 82
DDD 78
ACS 75
NADPH 75
NADPH 75
Norepinephrine 75
ACS 75
Milrinone 74
nicotinamide 73
Metformin 70
Metformin 70
leucine 70
NADH 68
Vasopressin 67
DPP 67
H2O2 66
TSH 66
Dopamine 66
Mg2+ 65
L-carnitine 65
Warfarin 64
Collagen 63
glutamate 62
Diabetol 61
phosphorus 60
MAP 60
Candesartan 58
Verapamil 58
Diabetol 58
PEP 58
Verapamil 56
ICI 56
Bisoprolol 55
GSH 53
GSH 53
PCI 53
galactose 53
ETA 52
dUTP 52
Propranolol 51
Salix 50
selenium 50
Adenosine 50
Hydralazine 50
Perindopril 50
H2S 49
methionine 49
N-acetylcysteine 49
copper 49
Sildenafil 49
Propranolol 48
alanine 48
CoA 47
Nifedipine 46
Xamoterol 45
prostaglandin E1 42
Abbott 42
A 71 42
proline 41
Telmisartan 40
Nitroglycerin 39
bromide 38
Coenzyme Q10 38
MTT 37
Heparin 37
Vitamin D 37
glycerol 37
ACh 37
FK506 37
Statin 35
ACTH 35
Salt 34
5-HT 34
A 42 33
Glucagon 33
Testosterone 33
cobalt 33
ISDN 33
Testosterone 33
PEG 32
MEK 32
6-12 32
A 3 31
more...