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Query: UMLS:C0018801 (heart failure)
 72,216 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We report a case of rhabdomyosarcoma involving the mitral valve of a 57-year-old female. She was referred to our hospital for progressive orthopnea and edema. Chest X-ray showed marked cardiomegaly and pulmonary congestion. Echocardiogram revealed solid mass in left atrium involving the mitral valve. Emergency operation was required because of acute heart failure. At the operation, the mitral orifice was obstructed by the tumor arising from the left atrium. After partial resection of the left atrium, mitral valve replacement with a Carpentier-Edward prosthesis was performed. Subsequently microscopic examination diagnosed as rhabdomyosarcoma. She died three months after the operation of heart failure probably due to progression of the remnant of the tumor. This, to our knowledge, is the first case of mitral valve replacement for a primary rhabdomyosarcoma of the heart in Japan.
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PMID:[A case report of primary rhabdomyosarcoma of the heart treated with mitral valve replacement]. 147 94

Specific-pathogen-free white leghorn chickens were inoculated at 1 day of age with avian leukosis virus (ALV, RAV-1). All chickens in Expt. 1, killed 33 or 64 days postinoculation, had focal chronic lymphocytic or lymphoplasmacytic myocarditis. Among those held beyond 33 days, eight of 22 developed lesions in the myocardium that resulted in a chronic circulatory syndrome (CCS) typical of right-sided heart failure. Chickens in Expt. 2 were held for 210 days, and 21% of 125 developed CCS. In Expt. 2, ALV particles were found by electron microscopy in myocardium of 100%, 72%, and 89% of inoculated chickens that developed CCS, lymphoid leukosis, or that had no gross lesions, respectively. These findings were in accord with the immunoperoxidase staining of tissue sections for group-specific antigen of ALV. In areas of extensive virus replication, there were often abnormal virus particles and also round bodies, which may have been remnants of host-cell membranes formed in the budding process. In contrast to findings in hearts, the spleens were usually negative for virus and viral antigen.
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PMID:Chronic myocarditis and circulatory syndrome in a White Leghorn strain induced by an avian leukosis virus: light and electron microscopic study. 215 91

This paper reviews a series of 70 consecutive children with rhabdomyosarcoma (RMS) diagnosed during 1971-1978 and treated in five Italian institutions. Thirteen were classified as group I, 12 as group II, 37 as group III, and 8 as group IV according to the Intergroup RMS Study staging system. Survival was influenced by tumor extension at diagnosis, primary site, and response to therapy. The 5-year-survival rate was 92% for group I patients, 67% for group II, 44% for group III, and 0% for group IV. Thirty-four children had all therapy stopped after 12-32 months of complete remission, 7 had late recurrences, and 3 died from disease. Musculoskeletal sequelae were diagnosed in 11 children, short stature in 3, corneal opacity in 2, and cardiac failure in 1.
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PMID:Long-term results in childhood rhabdomyosarcoma: a retrospective study in Italy. 315 51

The patient, a 33 year old male, had suffered from swelling of the chest, neck and face for 4 months; palpitation, chest and epigastrium pain, cough and yellowish sputum for 10 days before admission into our hospital. Blood routine and erythrocyte sedimentation rate were normal. By X-ray examination, the right upper mediastinum was obviously widened with the trachea displaced toward the left and pleural effusion was present on both sides. On day 5 of admission, the patient died of heart failure. The clinical diagnosis was not clear but lymphosarcoma or other malignant tumors in the mediastinum was suspected. Autopsy was performed. A large tumor 8 X 10 X 2.5 cm in size was found in the right atrium. The tumor had a short and broad pedicle (6 X 5 cm in diameter) connected with the upper part of the atrial wall. The histological diagnosis was primary rhabdomyosarcoma of the heart.
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PMID:[Primary rhabdomyosarcoma of the heart--a case report]. 374 56

Nine infants with episodic or continuous chaotic atrial rhythm (CAR) are presented. In addition to 3 or more different P-wave contours, atrial rates greater than 100 per minute, variable PP, RR, and PR intervals, and a discrete isoelectric baseline, findings included atrial rates that varied from a low of 50 to 120 to a high of 140 to 270 per minute, ventricular rates that varied from a low of 40 to 50 to a high of 180 to 270 per minute, and periodic sinus arrest with junctional escape rhythm. Except for the arrhythmia, all had a normal cardiac examination, ECG, chest x-ray film, and echocardiogram. Six infants were otherwise normal; one had an orbital rhabdomyosarcoma; one had neonatal asphyxia; and one had respiratory distress, bronchopulmonary dysplasia, and an intraventricular cerebral hemorrhage. The CAR persisted from 3 days to 20 months; it spontaneously reverted to normal sinus rhythm in 8 infants and persists in 1 infant at age 7 months. Digoxin (4 patients), propranolol hydrochloride (3 patients), quinidine sulfate (2 patients), and lidocaine (1 patient) did not alter the CAR. No patient had heart failure secondary to the CAR, although three also had episodes of sustained atrial tachycardia, which while present caused heart failure. All patients are functioning normally at home and have normal findings on cardiac examination and have normal ECGs at ages 3 to 38 months. Seven are in normal sinus rhythm, one has rare atrial premature contractions, and one has persistent CAR. We conclude that specific treatment was not necessary in these infants with CAR, except in those with associated sustained atrial tachycardia, which itself may cause heart failure.
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PMID:Multifocal or chaotic atrial rhythm: report of nine infants, delineation of clinical course and management, and review of the literature. 711 Oct 53

At the age of three months an infant rapidly developed signs of cardiac failure as well as in- and exspiratory stridor, caused by an intrathoracic tumor. Thoracotomy and biopsy revealed an intrapericardial tumor, histologically myxosarcoma. In spite of chemotherapy and radiation the infant died at the age of seven months due to multiple intracerebral metastases now histologically rhabdomyosarcoma. This is one of the rare cases of primarily malignant intrapericardial tumors in infancy, and also shows the possible pleomorphism of childhood rhabdomyosarcoma. We know only one further case of pericardial rhabdomyosarcoma where similar histologic changes have been observed.
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PMID:[Intrapericardial rhabdomyosarcoma in infancy (author's transl)]. 732 26

The aim of this study was to identify patients treated in Great Britain for childhood cancer and subsequently referred for cardiopulmonary transplantation in order to assess diagnosis, cancer treatment, management and outcome. Computerised record linkage between the National Registry of Childhood Tumours and the national transplant database held and maintained by the United Kingdom Transplant Support Service Authority (UKTSSA) was used to identify patients. Verification and clinical details were then obtained from the oncology and transplant centres. 16 patients were identified from the 31992 cases of childhood malignancy diagnosed in Britain since 1970. These comprised 13 heart transplants, 2 heart/lung transplants and 1 patient who died while on the heart transplantation waiting list. All 14 potential heart transplant patients had cardiomyopathy presumed secondary to anthracycline therapy. The original diagnoses were acute myeloblastic leukaemia (3), Wilms' tumour (4), rhabdomyosarcoma (2) and one each of five different solid tumours. Median age at diagnosis was 44 months (range 4-165 months). Median anthracycline dose was 413 mg/m2 (range 240-680 mg/m2). 13 of the 14 potential cardiac transplantation patients were more than 2 years from end of their cancer treatment before requiring transplantation and the transplantation was performed 2-126 months after onset of cardiac failure at a median age of 163 months. Five year actuarial survival from transplantation was 74%. There was no recurrence of the original malignancy in any of these patients. Both heart/lung patients died, 3 and 11 months after the transplant. These heart transplantation data suggest that, in Britain, survival compares favourably with that of patients whose heart transplant was required for other causes of cardiomyopathy. This indicates that patients successfully treated for childhood cancer should not be excluded from transplant programmes.
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PMID:Cardiac transplantation in childhood cancer survivors in Great Britain. 908 61

A seven-year-old, female German shepherd mixed-breed dog was presented with weakness, inappetence, and a distended abdomen. Right-sided heart failure with pleural, pericardial, and abdominal effusions; dyspnea; and tachycardia were identified. The radiographic and electrocardiographic examinations did not allow a conclusive diagnosis. Echocardiographic findings included a mass in the wall of both the right atrium and right ventricle, partially occupying the right heart cavities. A diagnosis of cardiac tumor was made, and the owner elected euthanasia. The necropsy confirmed a tumor mass located in the right atrium and right ventricle. A definitive diagnosis of primary cardiac rhabdomyosarcoma was based on histopathological and immunohistochemical analyses.
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PMID:Right-sided heart failure in a dog with primary cardiac rhabdomyosarcoma. 959 Apr 48

We report a case of a heart transplantation in a 12-year-old girl 9 years after extensive lung resection and adjuvant chemo- and radiotherapy for intra-thoracic embryonic rhabdomyosarcoma. She had restrictive cardiomyopathy with severe heart failure and chylous ascites. She was treated successfully with orthotopic heart transplantation and her symptoms of chylous ascites subsided gradually after transplantation. Her abdominal girth decreased from 79 cm before the transplant to 53 cm 9 months after the transplant.
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PMID:Orthotopic heart transplantation in a child with severe heart failure and chylous ascites. 1287 53

A rare case of left atrial rhabdomyosarcoma is presented in a patient with symptoms of congestive heart failure mimicking a hemodynamically obstructive mitral stenosis and secondary pulmonary hypertension. Although the diagnosis of a cardiac neoplasm is often difficult, it should be suspected in any patient with idiopathic heart failure refractory to conventional therapy, or with systemic or pulmonary emboli without an obvious source. The possibility of a "tumor plop" should always be considered during auscultation of a diastolic click. If clinically suspected, echocardiography will usually establish the diagnosis and allow follow-up for recurrences. If the tumor is benign, cardiac surgery will be curative and, if malignant, chemotherapy or radiotherapy should be considered.
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PMID:Left atrial rhabdomyosarcoma mimicking mitral valve stenosis. 1522 49


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