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Query: UMLS:C0018801 (heart failure)
 72,216 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Myotonic dystrophy (MD) is a neuromuscular disorder of autosomal dominant inheritance, which is categorized by 2 main sub-types: type 1 (MD1) and type 2 (MD2). This disease is characterized by myotonia and various multisytemic complications, most commonly of the cardiac, endocrine, and central nervous systems. In addition, cardiac abnormalities contribute to a significant morbidity and mortality in these patients. The cardiac abnormalities common to MD1 are conduction defects, such as first-degree atrioventricular block, arrhythmias, and other less common manifestations such as heart failure, ischemic heart disease, and mitral valve prolapse. Although these cardiac manifestations are also common in MD2, another complication that has been linked to MD2 is cardiomyopathy. Further study needs to be performed to better understand the pathology and management of these cardiac disorders associated with MD.
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PMID:Myotonic dystrophies and the heart. 2214 78

Cardiac involvement in classical Steinert muscular dystrophy (dystrophia myotonica, MD1) is characterised by atrial arrhythmias, AV conduction disturbance, ventricular arrhythmias and heart failure. In MD1 patients complaints of fatigue and reduced exercise tolerance are well explained by the muscular weakness, but the same symptoms can be attributed to arrhythmia, atrioventricular block and heart failure. As cardiac pathology is often encountered in MD1 patients, an ECG, echocardiogram and Holter registrations should be performed on a routine basis. We report on two patients with MD1 who developed Mobitz II block as initial presentation of cardiac disease.
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PMID:Pacing for conduction disturbances in Steinert's disease: a new indication for biventricular ICD? 2569 50