Gene/Protein
Disease
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Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
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Target Concepts:
Gene/Protein
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Query: UMLS:C0018801 (
heart failure
)
72,216
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
GAS2L3
is a recently identified cytoskeleton-associated protein that interacts with actin filaments and tubulin. The in vivo function of
GAS2L3
in mammals remains unknown. Here, we show that mice deficient in
GAS2L3
die shortly after birth because of
heart failure
. Mammalian cardiomyocytes lose the ability to proliferate shortly after birth, and further increase in cardiac mass is achieved by hypertrophy. The proliferation arrest of cardiomyocytes is accompanied by binucleation through incomplete cytokinesis. We observed that
GAS2L3
deficiency leads to inhibition of cardiomyocyte proliferation and to cardiomyocyte hypertrophy during embryonic development. Cardiomyocyte-specific deletion of
GAS2L3
confirmed that the phenotype results from the loss of
GAS2L3
in cardiomyocytes. Cardiomyocytes from
Gas2l3
-deficient mice exhibit increased expression of a p53-transcriptional program including the cell cycle inhibitor p21. Furthermore, loss of
GAS2L3
results in premature binucleation of cardiomyocytes accompanied by unresolved midbody structures. Together these results suggest that
GAS2L3
plays a specific role in cardiomyocyte cytokinesis and proliferation during heart development.
...
PMID:Deletion of Gas2l3 in mice leads to specific defects in cardiomyocyte cytokinesis during development. 2893 71
