Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0018801 (heart failure)
 72,216 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We report a case of acute interstitial nephritis (AIN) after a six weeks' therapy with sulphinpyrazone (Anturane, Ciba-Geigy, Wien). The patient presented with acute renal failure requiring hemodialysis. He died from acute cardiac failure three days after admission. According to our available information, it seems to be the first case of histologically proven acute interstitial nephritis with renal failure requiring hemodialysis after sulphinpyrazone therapy. Our observation underlines the suggestions made by Butler (7) and Mayrhofer et al. (19): During sulphinpyrazone therapy, serum creatinine and urea concentrations should be controlled regularly; the drug must be discontinued immediately when renal function is worsening; and the drug should not be administered in patients with even slightly impaired renal function.
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PMID:[Acute interstitial nephritis and kidney failure requiring dialysis after sulfinpyrazone therapy]. 623 42

Clinical observations suggest that sulfinpyrazone (Anturan) may lead to edema formation in borderline compensated cardiac insufficiency. Since the drug is increasingly used in secondary prophylaxis of sudden death after myocardial infarction, a trial was designed to confirm or to refute the suspicion that sulfinpyrazone may interfere with natriuresis. In two experimental series, 18 volunteers were given a sodium load of 5 g or 6 g and natriuresis was first measured at hourly intervals for 4 hours and thereafter for an additional 4-hour period. The experiment was repeated with a single dose of 400 mg sulfinpyrazone given with the sodium load. In the first, non-randomized trial (n = 8) 71.2 +/- 20.7 (SD) mval Na was excreted within 8 hours without, and 41.2 +/- 20.6 mval with sulfinpyrazone (p less than 0.05). In the second, randomized trial (n = 10), sodium excretion fell from 74.2 +/- 38.0 mval/8 h in the control experiment to 43.5 +/- 20.6 mval/8 h after sulfinpyrazone (-42%; p less than 0.05). Excretion of potassium and creatinine remained unchanged. It is concluded that sulfinpyrazone does indeed interfere with normal renal sodium excretion and that the phenomenon may be relevant in patients with borderline compensated myocardial insufficiency. The design of the trial provides a relatively easy way to obtain valuable information on the clinically relevant antinatriuretic side effects of many drugs, particularly that of non-steroidal antiinflammatory agents.
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PMID:[Antinatriuretic effect of sulfinpyrazone]. 726 56