Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0018801 (
heart failure
)
72,216
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
An instrumental and roentgenological examination was conducted in 164 patients who had survived myocardial infarction 1 to 10 years before the examination and having been free of any clinically manifest signs of congestive heart failure. The investigation included a study of the inotropic and pump function of the myocardium of the left ventricle, the electric and mechanical activity of the left atrium, the pulmonary haemodynamics under bicycle tests of growing power, and under identical conditions after premedication with cardiac glycosides (0.00036 mg/kg of body weight of
Strophanthin K
). Proceeding from the study of the readaptation of the circulation system and its transit to the initial stage of
cardiac insufficiency
the authors developed criteria of the onset of therapy for latent
cardiac failure
in patients with postinfarction cardiosclerosis.
...
PMID:[Initial stage of cardiac insufficiency as a complication of a past myocardial infarct]. 87 Jul 38
In order to examine the question, whether improved digitalis tolerance by Spirolactone may be partially a result of antagonism on myocardial potassium balance, 6 patients without clinical signs of
heart failure
were given 400 mg, 3 were given 200 or 300 mg Spirolactone orally daily and 6 patients received placebo during a 5 to 7 days period. During cardiac catheterization hemodynamics and serum potassium concentrations were determined repeatedly prior to and following intravenous administration of 0,375 to 0,625 mg
Strophanthin
. Injection of
Strophanthin
resulted in a significant drop in left ventricular enddiastolic pressure and a rise in dp/dt max. In the control group a significant increase in arterial and coronary sinus potassium concentration was observed. Myocardial potassium balance was definitely negative from the third to the eighth minute. Values in the group receiving Spirolactone did not differ significantly from the placebo group. It is suggested that therapeutic doses of
Strophanthin
resllt in a loss of potassium from the myocardium by inhibition of the Na+, K+ membrane ATPase not influenced by pretreatment with Spirolactone.
...
PMID:[Influence of spirolactone on the myocardial potassium balance following strophanthin in man (author's transl)]. 97 68
