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Target Concepts:
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Query: UMLS:C0018801 (
heart failure
)
72,216
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Mitochondrial mechanism of oxidative stress and matrix metalloproteinase (MMP) activation was unclear. Our recent data suggested that MMPs are localized to mitochondria and activated by peroxynitrite, which causes cardiovascular remodeling and failure. Recently, we have demonstrated that elevated levels of homocysteine (Hcy), known as hyperhomocysteinemia (HHcy) increase oxidative stress in the mitochondria. Although HHcy causes
heart failure
, interestingly, it is becoming very clear that Hcy can generate hydrogen sulfide (H2S), if the enzymes cystathionine beta-synthase (CBS) and
cystathionine gamma-lyase
(
CGL
) are present. H2S is a strong anti-oxidant and vasorelaxing agent. Paradoxically, it is interesting that Hcy, a precursor of H2S can be cardioprotective. The
CGL
is ubiquitous, while the CBS is not present in the vascular tissues. Therefore, under normal condition, only half of Hcy can be converted to H2S. However, there is strong potential for gene therapy of CBS to vascular tissue that can mitigate the detrimental effects of Hcy by converting it to H2S. This scenario is possible, if the activities of both the enzymes (CBS and
CGL
) are increased in tissues by gene therapy.
...
PMID:Homocysteine, hydrogen sulfide (H2S) and NMDA-receptor in heart failure. 2036 7
Hydrogen sulfide (H
2
S), the third gasotransmitter after nitric oxide (NO) and carbon monoxide (CO), is a critical neuromodulator in the pathogenesis of various diseases from neurodegenerative diseases to diabetes or
heart failure
. The crosstalk between NO and H
2
S has been well established in mammalian physiology. In planta, NO is demonstrated to regulate lateral root formation by acting downstream of auxin. The recent reports revealed that H
2
S is a novel inducer of lateral root (LR) formation by stimulating the expression of cell cycle regulatory genes (CCRGs), acting similarly with NO, CO, and IAA. Interestingly, during the initiation of lateral root primordia, IAA is a potent inducer of endogenous H
2
S and CO, which is produced by
L
-
cysteine desulfhydrase
(LCD) and heme oxygenase-1 (HO-1), respectively. The increasing evidences suggest that H
2
S-promoted LR growth is dependent on the endogenous production of CO. In addition, our results indicate that the H
2
S signaling in the regulation of LR formation can be associated to NO and Ca
2+
. In this addendum, we advanced a proposed schematic model for H
2
S-mediated signaling pathway of plant LR development.
...
PMID:Hydrogen sulfide is a novel gasotransmitter with pivotal role in regulating lateral root formation in plants. 2483 31
