Gene/Protein
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Pivot Concepts:
Gene/Protein
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Enzyme
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Target Concepts:
Gene/Protein
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Query: UMLS:C0018801 (
heart failure
)
72,216
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Two models of
heart failure
were used in rat experiments to study the effect of isoptin on tolerance to the toxic effect of k-strophanthin. Calcium antagonist-induced changes in the cardiotonic and chronotropic effects of the cardiac glycoside and myocardial oxygen consumption were examined in isolated frog atria with a movable-electrode electron tube and polarography.
Isoptin
was shown to substantially enhance tolerance to the toxic effect of k-strophanthin and slightly decrease positive inotropic effects of the cardiotonic, by slowing down its development rate. The agent potentiated the negative chronotropic action and lowered myocardial oxygen consumption.
...
PMID:[Effect of isoptin on toxic and cardiotonic effect of strophanthin K]. 796 27
