Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0018801 (heart failure)
 72,216 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The only effective treatment of an aortocaval fistula is the surgical closure of the fistula opening with insertion of an aortic prosthesis to restore the arterial continuity. The diagnosis of this distinct but infrequent clinical entity is often missed because of lack of suspicion. Proper preoperative evaluation facilitates the choice of surgical approach and reduces the morbidity. Three patients are presented with an aortocaval fistula: two with spontaneous rupture of an atherosclerotic abdominal aneurysm into the inferior vena cava and one with a traumatic fistula following intervertebral disk surgery 33 years before. All three patients suffered from pain in the abdomen and back, a palpable pulsatile abdominal mass and an audible continuous harsh bruit. Cardiac failure was present in two of them. Successful surgical closure could be accomplished in two patients although the perioperative course was complicated by ventricular arrhythmia, profuse blood loss and an inferior vena cava syndrome. One patient with a spontaneous aortocaval fistula passed away due to intraoperative exsanguination.
 ...
PMID:Aortocaval fistulas. 202 5

In 1984-88 the authors examined in 813 subjects with the chest pain syndrome of varying aetiology (acute myocardial infarction, myocarditis, pericarditis, vertebrogenic algic syndrome, embolism of the pulmonary artery, patients lacking detectable organic causes of pain) the trend of myoglobin serum levels. They found significantly elevated values only in patients with myocardial infarction and myocarditis whereby the two diseases differ in particular as regards the shape of the curve of myoglobin values. In chest pain with another aetiology the myoglobin levels rose only rarely or not at all. From the differential diagnostic aspect it is particularly valuable that myoglobin was not elevated in any patient with embolism of the pulmonary artery and only very rarely in angina pectoris. Where in exceptional instances the myoglobin levels were elevated in patients with other investigated causes of chest pain, this increase was always due to another basic disease (right-sided cardiac failure, renal insufficiency, neuromuscular disease), whereby for these conditions prolonged persistence of the elevated serum myoglobin values was typical and the levels were never above 8 nmol/l.
 ...
PMID:[The significance of myoglobin determination in the differential diagnosis of chest pain syndrome]. 205 2

A prospective study was done on 110 patients, 55 Chinese and 55 American elderly who had clinically proved acute myocardial infarction with histologic confirmation. The Chinese patients were much more likely to have typical pain than the American (65.4% vs 49.0%). The incidence of painlessness was only 18.1% vs 36.3%. The difference has statistical significance (P less than 0.05). Cardiac failure, shock, pulmonary infection as a major complication had no statistical significance, but the incidence of cardiac rupture group was 29.0% vs 10.9%. Ventricular fibrillation incidence was 18.1% in the Chinese vs 45.4% in the American. The incidence of recent occlusive coronary thrombi, hemorrhage and rupture of plague in coronary arteries had significant statistical difference. The incidence of triple, double and single vessel diseases were 41.8%, 29.0% and 27.2% in the Chinese group vs 36.3%, 27.2% and 25.4% in the American respectively.
 ...
PMID:A clinicopathologic comparison of acute myocardial infarction in the elderly Chinese and American. 211 26

We describe a girl aged 17 y who died after a cardiac arrest secondary to septic shock. At autopsy, the enlarged, soft, and flabby heart showed microscopic evidence of acute myocardial infarction, myocardial edema, myocardiocyte loss, replacement fibrosis in the interventricular septum, and right and left ventricular hypertrophic nucleomegaly. The pathological diagnosis was that of cardiomyopathy due to prolonged selenium deficiency. The patient had been on total parenteral nutrition for 17 mo, following extensive bowel resection for intractable pain, nausea, and vomiting caused by chronic idiopathic intestinal pseudoobstruction. Seven months before death, when severe biochemical selenium deficiency was diagnosed, supplemental selenium was added to the infusion, and plasma selenium concentrations increased. In long-standing selenium deficiency, sepsis may contribute the final insult to a damaged myocardium, triggering symptomatic cardiac failure and sudden death.
 ...
PMID:Cardiomyopathy associated with nonendemic selenium deficiency in a Caucasian adolescent. 216 25

There is abundant evidence from angiographic studies that reperfusion and/or patency rates are greater when thrombolysis is initiated earlier. Evidence of a reduction in infarct size has been provided by a number of studies, which have also suggested that earlier therapy preserves left ventricular function. The major intravenous thrombolytic mortality trials appear to confirm the importance of delivering therapy soon after the onset of symptoms e.g. GISSI and ISIS-2. However, the benefit reported in the first hour in GISSI may be questioned. Furthermore, it seems probable that those coming in late to trials are patients who did not have a sudden onset of symptoms, but whose symptoms persisted, perhaps with recurrent pain, or with heart failure symptoms. This may account for the fact that the benefit seen relatively late, particularly in ISIS-2, does not seem to accord with reperfusion, infarct size and LVEF findings. The true benefits of earlier therapy will be established only when patients are randomized to active therapy or placebo at one point in time and then switched to alternative therapy at a specified later time. This has been done in a small trial with alteplase in Belfast. The findings were suggestive but not conclusive of an improvement in LVEF in those treated earlier. The European Myocardial Infarction Project (EMIP) should go far towards answering the question. In most European cities the time between onset of symptoms and the initiation of skilled treatment for myocardial infarction is of the order of 5-6 h.(ABSTRACT TRUNCATED AT 250 WORDS)
 ...
PMID:Time as a factor in thrombolytic therapy. 222 42

Shoulder pain is a frequent and debilitating problem in hemiplegic patients, and its etiology remains poorly understood. The role played by hemineglect in the appearance of shoulder pain was studied. During two years, 94 hemiplegic subjects were involved in a rehabilitation program after cerebrovascular accidents. Their average age was 68 years; 45 (47.9%) subjects had shoulder pain, and 24 subjects (22.5%) had hemineglect. The subjects with shoulder pain were compared to those without pain (the control group) with respect to gender, age, diabetes, heart failure, cardiac ischemia, scapulohumeral arthritis, and calcified tendinitis of the rotator cuff. We were unable to demonstrate a relationship between hemineglect and shoulder pain in the hemiplegic (X2 (1) = 2.03, p = .15), although pain was significantly more frequent in subjects with right hemispheric cerebrovascular accident (X2 (1) = 5.0, p less than .025). The subjects with shoulder pain had significantly more spasticity of the affected limb (X2 (1) = 26.3, p less than .01), less sensitivity to pinprick of the upper paralyzed extremity (X2 (1) = 10.8, p less than .01), and a more severe subluxation of the affected shoulder (t(51) = 14.0, p less than .01).
 ...
PMID:Painful shoulder in the hemiplegic and unilateral neglect. 237 73

The authors evaluated retrospectively the course of the early stage of symptomatic myocardial infarction (IM) with regard to the incidence and character of infarction pain and the clinical course of IM during hospitalization at the coronary unit (CU) in a group of diabetic patients (D, n = 67) and a group of non-diabetic controls (ND, n = 63). In the group D there was a higher incidence of painless IM (D 7.5%, ND 0%, p less than 0.05). The interval between the development of the first symptoms of IM and admission to the CU was significantly longer in diabetics (D 20 +/- 35 hours, ND 9 +/- 16 hours, p less than 0.05). IM in diabetics was more frequently complicated by left-sided cardiac failure (D 48%, ND 27%, p less than 0.05). As to other investigated complications the two groups did not differ significantly. Nor did they differ in the mortality during hospitalization at the CU.
 ...
PMID:[The early phase of development of myocardial infarction in diabetics]. 239 90

Neuroendocrine activation in acute myocardial infarction (AMI) may have important physiological consequences for myocardial perfusion and function. We measured plasma angiotensin II in 60 patients with AMI within 6 hours of pain and on days 1-3 and day 10. On admission, AII was normal at 9.9 + 1.3 pmol/l (normal range 2-12 pmol/l). At day 3, AII rose markedly to 77.5 + 25.0 in those with heart failure (group 1, n = 13); but AII also rose in uncomplicated patients (group 2, n = 47) to 27.8 + 4.0 (p less than 0.001). At day 10, levels of AII remained high, especially in group 1 (50.5 + 22.2 vs 6.1 + 1.5, p less than 0.005). Thus neuroendocrine activation, present early in AMI, is seen in both uncomplicated infarcts and in those developing heart failure. Angiotensin II mediated vasoconstriction perhaps enhanced by catecholamines could have deleterious effects on myocardial function and perfusion, and indicates the potential for angiotensin-converting enzyme inhibitors in early AMI.
 ...
PMID:Neuroendocrine activation in acute myocardial infarction. 244 Nov 95

Our clinical and instrumental investigations showed that invasive laser therapy has a multiple therapeutic effect. Acting favourably on principal pathogenetic mechanisms of acute myocardial infarction, it decreases the pain syndrome, normalize electrical instability of the heart, limits myocardial ischemic damage area and accelerates scarring process. It leads to a decrease in mortality and in the incidence of severe complications of myocardial infarction such as ventricular fibrillation, cardiogenic shock, cardiac insufficiency. Thus, the new method of treating acute myocardial infarction with He-Ne laser irradiation significantly enhances treatment efficacy, improves the course and prognosis of myocardial infarction.
 ...
PMID:[Experiences with laser therapy in acute myocardial infarct]. 246 47

Transdermal nitroglycerin becomes more and more common mode of pharmacotherapy as this form of nitroglycerin ensures permanent therapeutic level of the drug in the blood serum for a long time. The largest clinical experience with transdermal nitroglycerin has been gathered in effort angina although it is used in all forms of ischemic heart disease. It has been documented that transdermal nitroglycerin improves exercise tolerance, increases pain threshold, delays the onset of ST segment depression in the ECG and decreases the incidence of anginal attacks. Beneficial effects of transdermal nitroglycerin on hemodynamic parameters have been shown also in patients with myocardial infarction, especially complicated by heart failure. First results obtained in the treatment of silent myocardial ischemia are very promising. The development of tolerance requires 12-hour intervals in the use of nitroglycerin patches.
 ...
PMID:[Transdermal use of nitroglycerin]. 251 62


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>