Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0018801 (heart failure)
 72,216 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Report on a girl with Seckel-syndrome (bird-headed dwarfism). In addition to the known symptomatology she had a congenital heart failure (ASD II, VSD, PDA). Endocrine evaluation revealed decreased growth hormone stimulation. In the CT-scan of the skull enlarged ventricles were demonstrated.
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PMID:[Seckel dwarfism based on a personal case]. 271 36

The frequency of arrhythmias was determined pre- and postoperatively in adult patients with secundum atrial septal defect. The study group consisted of 224 pts who had undergone surgical repair of ASD II in between 1987-1993. The mean postoperative follow-up was 7.5 y. The group (160 F, 64 M, aged 17-66 y) was divided on 3 subgroups: I--age under 20 y--27 pts, II--20-40 y--131 pts, III--over 40 y--66 pts. We analysed pre- and postoperative parameters: 1) arrhythmias in the 24-h Holter recording, 2) pulmonary hypertension (PASP-Doppler), 3) coexisting diseases, 4) functional class of heart failure (NYHA). Most common abnormalities found were supraventricular tachyarrhythmias (22.8 pre- and 40.6% postoperatively). There was significant increase in frequency of arrhythmias after surgery in the subgroups II and III. Arrhythmias were most frequent in patients with coexisting arrhythmogenic diseases.
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PMID:[Long-term follow-up of supraventricular tachyarrhythmia in adult patients with secundum atrial septal defect before and after surgery]. 1107 44

The aim of the study was to determine pre- and postoperative systolic pulmonary pressure in adult patients with ASD II. The study group consisted of 224 pts who had undergone surgical repair of ASD II in between 1987-1993. The mean postoperative follow-up was 7.5 y. The group (160 F, 66 M aged 17-66 years) was divided on 3 subgroups: age under 20 y--27 pts; 20-40 y--131 pts; and older then 40 y--66 pts. We analysed pre- and postoperative parameters: pulmonary hypertension (PASP-Doppler) and functional class (NYHA). Preoperative pulmonary pressure was 35-50 mm Hg in 69 pts (30.8%) of the group, and over 50 mm Hg in 29 (12.9%). In long-term follow-up of 98 (43.8%) operated patients with coexisting pulmonary hypertension, significant reduction of pulmonary pressure was observed in all patients, even in patients over 40 y. Functional class of heart failure NYXHA improved as well in all patients.
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PMID:[Pulmonary hypertension in adult patients with secundum atrial septal defect before surgery and in long-term follow-up]. 1107 45

We describe clinical presentation in a male newborn baby who presented with thumb aplasia, forearm hypoplasia and secundum atrial septal defect (ASD II). The child has no other bone anomalies or facial dysmorphism. The ultrasound morphology of the brain is normal. He has patent ductus arteriosus, without abnormalities in the ECG record. Complete blood count (CBC) is normal. In the spectrum of hereditary diseases from the group "heart-hand", clinical presentation in our patient corresponds to Holt-Oram syndrome (HOS). The role of the neonatologist in case of anomalies of the thumb or upper limb, is to exclude possible heart failure and instruct parents about timely, interdisciplinary care for the child.
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PMID:[Holt-Oram syndrome--the importance of early diagnosis and interdisciplinary approach. A case report]. 2360 71