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Query: UMLS:C0018801 (heart failure)
 72,216 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Allapinin after i.v. bolus infusion in a dose of 30 mg is relatively quickly eliminated from blood (in patients without congestive heart failure half-elimination period is 2.4 +/- 0.5 h and clearance is 79.0 +/- 8.9 l/h) which makes a good reason for its intravenous infusion according to the scheme "load dose + drop infusion". Marked heart failure in patients with acute myocardial infarction compared to patients without heart failure results in reduced elimination rate, decreased clearance, significantly increased plasma allapinin concentration which should be taken in account when choosing the regime of drug infusion. The elimination of allapinin is mainly metabolic and not renal (only about 17% of the drug is excreted with urine).
Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR 1989
PMID:[Allapinin pharmacokinetics after its single intravenous administration]. 266 28

27 patients with dilated cardiomyopathy (DCM) complicated by heart failure (HF) of stages I-IIB were studied. The density of lymphocyte beta 2-adrenoceptors decreased significantly as HF progressed. The level of circulating catecholamines (epinephrine, norepinephrine) was significantly higher in patients were severe HF, which probably caused more evident decrease in lymphocyte beta 2-adrenoceptors density in these patients. This point of view was confirmed by the data of correlation-regression analysis between the general beta 2-adrenoceptors density and hemodynamics data. The identified changes in the number of adrenoceptors reflect the process of cellular receptors desensitization. They should be considered as a possible mechanism of HF development on a molecular level that cause development of refractoriness to routine therapy.
Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR 1988
PMID:[The density of lymphocyte beta 2-adrenoreceptors and blood plasma catecholamines in patients with dilated cardiomyopathy]. 285 42

Rheologic blood parameters--fluidity limit tau 0, viscosity n alpha 1, erythrocyte cohesion coefficient (A), hematocrit--were studied in 42 patients with dilated cardiomyopathy (DCM) and 30 patients with ischemic heart disease (IHD) and heart failure of stages I-III. Rheologic parameters tended to increase along with progression of heart failure while in IHD an opposite tendency was observed. Individual analysis in patients with DCM as well as those with IHD demonstrated, irrespectively of the stage of heart failure, both hyper- and hyporheological syndromes. Occurrence of thromboembolic complications was in both cases nearly the same (42.9% and 40%, correspondingly). The data obtained indicate at evident abnormality of rheologic blood parameters in patients with dilated cardiomyopathy progressing along with development of heart failure and suggest its possible role in intravascular thrombi formation.
Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR 1988
PMID:[Blood rheologic properties in patients with dilated cardiomyopathy]. 323 59

In 20 patients with IHD without clinical symptoms of heart failure, diastolic pulmonary artery blood pressure (DPAP) and cardiac index (CI) were studied at rest and during physical load (bicycle exercise in sitting position). The control group consisted of 15 patients without any symptoms of coronary artery or myocardium damage. The patients with IHD exhibited several types of heart reaction to exercise. In 6 of 20 patients reaction of DPAP and CI corresponded to that in normal subjects: at maximal load DPAP did not exceed 16 mm Hg, and CI increased by more than 250%. The contractile function of the left ventricular myocardium in these patients was not disturbed when there was no angina attack. 7 patients with IHD exhibited disturbance of diastolic myocardium relaxation, and 7 more patients had myocardial disfunction of various degrees. Treatment was carried out according to the determined changes in DPAP and CI during exercise.
Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR 1987
PMID:[Diastolic pressure in the pulmonary artery and cardiac output in patients with ischemic heart disease during physical load]. 342 14

The authors worked out the method and formula of indirect determination of the left ventricular and diastolic pressure (LVEDP) on the basis of the determined direct relationship between the diastolic-systolic coefficient (DSC) of the differential chest rheogram (difTPCR) and the LVEDP value measured by direct method in patients with IHD. LVEDP = 18.4x + 5.5, where x = DSC TPCR. It was determined that difTPCR can help to determine the degree of the heart failure and to find out patients with unfavourable prognosis.
Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR 1987
PMID:[Clinical significance of diastolic-systolic coefficients of the tetrapolar chest rheogram in patients with ischemic heart disease]. 342 18

A randomized study of 60 patients with myocardial infarction (MI) admitted to hospital in the first 6 hours of the disease was performed in order to study the effect of phosphocreatine (PC) on the course of MI. 30 patients were treated with PC; control group consisted also of 30 patients. PC infusion in the early period of MI resulted in the decreased frequency of ventricular arrhythmias (including paroxysms of ventricular tachycardia) and lowered likelihood of cardiac failure development. No reliable influence of PC on the central hemodynamics, heart rate, heart conduction and myocardial necrosis size was determined.
Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR 1987
PMID:[Initial experience with using phosphocreatine in patients in the early (up to 6 hours) period of myocardial infarction]. 342 24

Results of 69 aortocoronary bypass operations with the use of microsurgery equipment were analysed. Perfusion was performed under conditions of constant flow, which made it possible to avoid transmissive pulsation, making difficulties for creating microanastomoses. One venous double opening canule was used with no drainage of the left ventricule, which made cannulation easier and created optimal technical conditions for the surgeon. Duration of extracorporeal blood circulation and frequency of intraoperational complications (cardiac failure, myocardial infarction) depended on the operational methods: initial creation of proximal anastomoses resulted in decreased duration of the perfusion, improved protection of myocardium and lower number of complications.
Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR 1987
PMID:[Artificial circulation in microsurgery of the coronary arteries]. 350 Dec 98

A total of 45 patients with congestive cardiomyopathy (CCMP) (41 males and 4 females aged 16-57 years) were examined. The study of the clinical picture of the disease has enabled two patient groups to be distinguished: group 1 included 16 patients aged 16-56 years with a rapidly progressive course of the disease and group 2 consisted of 29 patients aged 25-57 years with a slowly progressive form. The symptoms of heart failure were found in all the patients (18 with stage A and 27 with stage B). The cardiothoracal index was 0.64 in rapidly progressive CCMP and 0.58 in slowly progressive one. All the patients with CCMP had a characteristic marked dilatation of all the heart cavities, a sharp decrease in the indices of the pumping and contractile function of the myocardium. These changes were more marked in patients with rapidly progressive CCMP.
Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR 1982
PMID:[Clinico-hemodynamic variants of the course of congestive cardiomyopathy]. 621 28

Findings of echocardiography and bicycle exercise testing were considered objective hemodynamic criteria during long-term follow-up studies of patients with mitral stenosis and early stages of cardiac insufficiency. In patients with the first degree cardiac insufficiency the most sensitive parameters were: exercise tolerance, physical adaptation index and left atrial size. In patients with the second A degree cardiac insufficiency additional information has also been obtained upon studying the ejection fraction and the rate of left ventricular circular shortening.
Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR 1983
PMID:[Use of exercise tests and echocardiography during long-term observation of patients with mitral stenosis and cardiac insufficiency]. 663 60

The effect of nitroglycerin intravenously injected in 23 patients with heart failure (stage A and stage B), on the regional blood circulation (the chest, abdominal cavity, crus and finger) was studied by the method of impedansplethysmography. Various reactivity of capacious and resistive vessels of different vascular regions was found in reply to an intravenous injection of the drug. The redistribution of the venoarterial circulation in the regions studied occurred depending on the changes in the central hemodynamics. While administering nitrates to patients with circulatory failure it is necessary to take into account the state of the central and regional hemodynamics in the initially high total peripheral resistance. The control over changes of the pulse blood filling in different vascular vessels under the influence of nitroglycerin may be sufficiently informative for the choice of individual doses of the vasodilator and the assessment of the effectiveness of the therapy.
Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR 1982
PMID:[Regional circulatory changes in heart failure as affected by intravenous nitroglycerin administration]. 681 65


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