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Query: UMLS:C0018801 (heart failure)
 72,216 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Atrial bioelectrical activity (according to large-scale ECG findings) and central hemodynamics were studied in 43 coronary patients. A correlation analysis showed an increased correlation between the studied values in patients with diffuse and postinfarctional cardiosclerosis and those in healthy subjects. The authors stressed the most significant large-scale ECG values. A conclusion was made of the appropriateness of a study of atrial bioelectrical activity by the method of large-scale electrocardiography and hemodynamics for diagnostics in coronary patients with the initial stage of cardiac insufficiency.
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PMID:[Correlation between quantitative indicators of the bioelectrical activity of the heart atria and central hemodynamics in patients with ischemic heart disease based on correlation analysis data]. 373 85

The greater and lesser circulation: hemodynamics and external respiratory function were repeatedly examined in the course of treatment in 90 patients with atherosclerotic cardiosclerosis and circulatory insufficiency, stages I-IIB. In heart failure, hemodynamic shifts were earlier and more pronounced in the lesser circulation, as compared to the greater circulation. Respiratory insufficiency also preceded hemodynamic shifts in the greater circulation and was more pronounced in patients with pulmonary hypertension. In the course of treatment, these patients showed a more significant blood pressure fall in the pulmonary artery and progressively diminishing manifestations of respiratory insufficiency.
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PMID:[Hemodynamic aspects of heart and respiratory failures in ischemic heart disease patients with severe pulmonary hypertension and their dynamics during treatment]. 376 53

The myocardium of both heart ventricles in acute (AAP) and chronic (CAP) alcoholic poisoning was studied in 90 randombred rats. Functional-morphological changes typical of alcoholic cardiomyodystrophy were shown to develop in the heart in AAP and CAP. In AAP, alcoholic cardiomyodystrophy may lead to acute cardiac insufficiency and in CAP to progressive reduction of the contractile function of the heart and disturbances of conductivity in it. In AAP, however, the leading factor is the disturbance of bioenergetics as a result of toxic effect of ethanol and its metabolites on mitochondrial membranes under conditions of markedly disordered microcirculation. In CAP, along disordered microcirculation. In CAP, along with compensatory-adaptative processes in cardiomyocytes there increase the defects of the contractile apparatus, and diffuse fine-focal cardiosclerosis. This is the result of a long-term effect of ethanol and progressive hypoxia due to the affected vessels and disorders in lipid metabolism. Disorders in the function of sarcoplasmic reticulum may contribute to reduced contractile capacity of the heart.
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PMID:[Myocardium in acute and chronic experimental alcoholic intoxication]. 689 Jul 96

Forty patients with idiopathic hypertrophic subaortic stenosis have been studied. It was established that these patients had early signs of cardiac insufficiency (cardiac palpitations, fainting fits, dyspnoea) as a result of morphological changes in the myocardium (micro- and macrofocal cardiosclerosis). With the aid of contrast methods of investigation and phonography it was shown that in microfocal cardiosclerosis the index of the systolic murmur varies from 0.5 to 3, the planimetric index from 0.8 to 1.0. In macrofocal cardiosclerosis from 1.5 to 0 and less than 0.8, respectively.
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PMID:[Clinicodiagnostic aspects of idiopathic hypertrophic subaortic stenosis]. 719 66

An analysis has been made of the data of direct and indirect methods for evaluation of myocardial reserve and occult cardiac insufficiency in varying groups of patients with postinfarction cardiosclerosis and hypertensive disease. Absolute and relative values of the systolic AD, cardiac contraction rate and ECG data have been studied. A combined characteristics of the hyposystolic type reaction and the scheme for the examination of patients are presented.
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PMID:[Determination of the myocardial reserve by ergometry]. 731 1

While studying the functional activity of poly- and mononuclear leucocytes in 75 patients with various clinical types of ischemic heart disease (angina of effort, angina decubitus, arrhythmias, cardiac insufficiency at the background of atherosclerotic cardiosclerosis and atherosclerotic hypertension), decline in the functional activity of the phagocytizing cells has been revealed, this being considered to be a pathogenetic prerequisite for atherosclerosis progression.
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PMID:[The functional activity of the poly- and mononuclear leukocytes in patients with different clinical forms of ischemic heart disease]. 783 69

Microcirculatory bed of the epi- and pericardium, parietal pleura, bulbar conjunctiva is studied in congenital heart defects. The alterations of the microvessels were similar in all above organs. The following conclusions are made: a) the reduction of microvessels manifests as capillary failure of the myocardium resulting in cardiomyocyte destruction and development of cardiosclerosis, b) myocardial alterations result in heart failure and enhancement of systemic microhemocirculation, c) irreversible pathological processes can be prevented by early surgery only.
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PMID:[Microcirculatory disorders of the systemic circulation and the myocardium in congenital heart defects with a left to right shunt]. 809 44

The efficacy of captopril (capoten) and digoxin was comparatively studied in long-term randomized, double blind trials of 22 male patients with postinfarction cardiosclerosis, functional classes I-III and preserved sinus rhythm. The optimal doses of the drugs proved to be small (0.31 and 35 mg/day of digoxin and capoten, respectively). No adverse effects were noted. The mortality rate was 10 and 16.7% with digoxin and captopril, respectively. The drugs equally improved the functional class by 0.51 and 0.45 and VO2 max by 1.5 and 1.7 ml/min. Digoxin had a mild effect on heart rate (-8.4%) and ejection fraction (+5.7%) and deteriorated diastolic relaxation, by slowing down the early peak of transmitral Doppler spectrum by 16.2%. Captopril significantly improved diastolic function by increasing the early peak by 17.2%. No significant changes in left ventricular sizes were recorded. The clinical efficacy of captopril was explained by a significant decrease in angiotension II (70%) and norepinephrine (40%) levels and by associated normalization of baroreflex regulation. Digoxin insignificantly affected the levels of angiotensin II and norepinephrine, but improved the baroreceptor regulation of sympathetic control impaired in chronic heart failure. It is concluded that extracardiac mechanisms play a major role in the action of not only captopril, but digoxin in the treatment of patients with postinfarct cardiosclerosis and chronic heart failure with sinus rhythm.
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PMID:[Comparative study on use of angiotensin-converting enzyme inhibitors and cardiac glycosides in the treatment of cardiac insufficiency]. 819 54

The 24-h profile of blood pressure (BP) was studied in 28 patients (21 males and 7 females) with congenital heart failure (CHF) of NYHA class II-III (ejection fraction < 45%). The patients were 46 to 76 years of age and had postinfarction cardiosclerosis. They had not received ACE inhibitors before. Two groups were formed basing on the presence of hypertension. Perindopril was administered in a single daily dose of 2 mg or higher if demanded to reduce symptoms of CHF and/or to normalize BP. The treatment continued for 3 months. The 24-h BP profile was assessed using portable device SpaceLabs 90207 (USA). In CHF patients with hypertension perindopril significantly lowered mean 24-h, day and night BP and its loads, reestablished two-phase circadian rhythm of AP and corrected BP variability. In CHF patients free of hypertension significant changes of the profile were not registered. It is evident that unwanted changes in the BP 24-h profile due to perindopril were absent in CHF normotensives.
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PMID:[Change of circadian pattern of arterial pressure in patients with congestive heart failure treated with perindopril, an inhibitor of angiotensin-converting enzyme (ACE)]. 950 33

Left ventricular remodelling plays an important pathogenetic role in progressive circulatory insufficiency both in dilated cardiomyopathy (DCMP) and in ischemic heart disease with postinfarction cardiosclerosis. In terminal cardiac failure structural changes (changed geometry of the left ventricle, in particular) become stereotypic. The dobutamin test in DCMP reveals low functional reserve of the total and segmentary contractility compared to ischemic cardiomyopathy. This may help in echocardiographic diagnostic difficulties.
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PMID:[Comparative characteristics of left ventricular remodeling in dilatation cardiomyopathy and ischemic disease]. 950 6


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