Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0018801 (heart failure)
 72,216 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Data derived from clinical, electro- and polycardiographic observations of 68 patients subjected to electric stimulation therapy are presented. The evaluation of late results of the treatment showed that clinical factors such as the patients' age, the nature of the affection, the degree of cardiac insufficiency, the standing of auricular fibrillation are not decisive in determining indications and contraindication for electric stimulation therapy. A considerable worsening of the cardiac dynamics with developing fibrillation arrhythmia, especially in patients suffering from cardiosclerosis, and a distinct improvement of the polycardiographic indices after defibrillation point to the need of attempting, whenever this is possible, to bar the auricular fibrillation. A pretreatment with potassium preparations and lengthy maintenance therapy with quinidine or quinidine-like agents is recommended. An analysis of the ECG findings after the electric stimulation therapy (heart rate, and its regularity, the state of the intraatrial and atrioventricular conduction) enable it to foresee the retention time of the re-established rhythm.
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PMID:[Electroimpulse therapy of auricular fibrillation]. 23 37

The clinical suggestion on the dysfunction of the mitral valve in 20 patients with post-infarction cardiosclerosis was confirmed by ventriculography (8 persons) and in autopsy (12 persons). The paper presents a clinical characteristics of the both groups of patients, the indices of the central hemodynamics, the end diastolic pressure in the left ventricle of the heart, coronaroangiography, as well as morphometric data of the examination of the hearts and of the extent of the scar lesions of the myocardium in patients who died of congestive cardiac insufficiency against the background of postinfarction cardiosclerosis combined with the papillary muscle affection.
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PMID:[Role of mitral valve dysfunction in the development of cardiac insufficiency in postinfarct cardiosclerosis]. 85 42

An instrumental and roentgenological examination was conducted in 164 patients who had survived myocardial infarction 1 to 10 years before the examination and having been free of any clinically manifest signs of congestive heart failure. The investigation included a study of the inotropic and pump function of the myocardium of the left ventricle, the electric and mechanical activity of the left atrium, the pulmonary haemodynamics under bicycle tests of growing power, and under identical conditions after premedication with cardiac glycosides (0.00036 mg/kg of body weight of Strophanthin K). Proceeding from the study of the readaptation of the circulation system and its transit to the initial stage of cardiac insufficiency the authors developed criteria of the onset of therapy for latent cardiac failure in patients with postinfarction cardiosclerosis.
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PMID:[Initial stage of cardiac insufficiency as a complication of a past myocardial infarct]. 87 Jul 38

Digoxin concentrations were studied in the blood serum of 128 patients with cardiac insufficiency of different etiology (acute myocardial infarction, postinfarction cardiosclerosis, mitral valve disease). Radioimmunoassay with standard kits was employed, the kits containing 125 I-labelled Digoxin. Mean concentrations of Digoxin were determined in the blood serum corresponding to different maintenance doses of the drug. It was found that signs of overdosage usually appear with concentrations exceeding 2.5 ng/ml. Disorders in the renal excretory function in patients with severe edematous syndrome help a prompt cumulation of Digoxin and the development of glucoside intoxication. Some patients demonstrated a reduced Digoxin tolerance in the acute period of their myocardial infarction. The advantages of the radioimmunoassay, especially in severely ill patients with cardiac pathology are emphasized.
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PMID:[Radioimmune method of determining the concentration of digoxin in the blood during treatment of patients with cardiac insufficiency]. 101 88

The paper presents the results of an examination of 62 patients with postinfarction cardiosclerosis by means of echocardiography and ultrasonic scanning. The impact of the asynergy zone on the development of cardiac insufficiency was studied with reference to the area of myocardial lesion. Myocardial hyperkinesia is characterized, its compensatory effect in postinfarction cardiosclerosis and arterial hypertension is discussed. The effect of Inderal and Ildomen on both the zones of hyperkinesia, and on the indices of cardiac haemodynamics as a whole is described.
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PMID:[Importance of myocardial asynergy zones in the development of cardiac insufficiency]. 101 9

Over 400 operations of an indirect revascularization of the myocardium have been performed at the A.I. Bakulev institute of Cardiovascular Surgery of the USSR Academy of Medical Sciences. Since 1970, the direct method have been developed, predominantly those of aorto-coronary bypass. Careful examination of 709 patients was carried out, 445 of them were subjected to selective coronary angiography, 108 were operated on. In 1974, 56 operations were undertaken, among them 36 aorto-coronary bypasses, in 6 of them with a preliminary endarterectomy from the coronary artery, 8 double bypasses, 6 procedures for acute myocardial infarction, 5 combined operations of aorto-coronary bypass and resections of cardiac aneurysms, and 15 resections of postinfarction aneurysms of the heart. Twelve patients died in the postoperative period, mainly due to acute cardiac insufficiency. The high figures of mortality are caused not only by the faults of the surgical procedures but also by the grave initial state of the patients (multiple coronary lesions large focal cardiosclerosis due to preceeding infarctions, high degree of initial cardiac insufficiency). The improvement of the results of surgery for the ischaemic heart disease will depend on the perfection of the surgical technique, on proper selection of the patients, and on the precise determination of the indications for such treatment.
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PMID:[Surgical treatment of severe forms of ischemic heart disease]. 108 45

The radioisotope method with Rb86 was used for determining in vitro the serum concentration of Digoxin. The study was conducted in 57 patients with cardiac insufficiency in the acute period of myocardial infarction and with post infarction cardiosclerosis. The mean values of Digoxin concentration depending on the daily maintenance dose were obtained. The direct correlation between the amount of the drug taken and the content of the drug in the blood serum was proved. Digoxin intoxication was found to develop in cases of its content exceeding the mean level for the given dosage (4 patients), however, in 2 patients signs of intoxication developed with a low concentration of Digoxin. The causes favouring the development of intoxication are discussed.
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PMID:[Treatment of circulatory insufficiency in patients with ischemic heart disease with digoxin and determination of its concentration in the blood serum by radioisotope method]. 120 42

The relationship was examined between the severity of heart failure, the degree of asynergy and exercise tolerance in 40 males under 60 years with postinfarction cardiosclerosis. Fifteen healthy males were matched for as a control. Echocardiography was performed before and after bicycle ergometer exercise test, allowing the patients to be divided into 4 groups: Groups 1 and 2 without an ischemic response in the absence or presence of akinesia or dyskinesia, respectively; Groups 3 and 4 with an ischemic response in the absence or presence of akinesia or dyskinesia, respectively. The lowest exercise tolerance was observed in Group 4. Echographic findings showed that the overall left ventricular contractility was diminished in all the patients; there was no noticeable quantitative difference in the values between the groups. No differences were found in segmental ejection fractions. The combination of ischemic response to exercise tolerance and akinesia-dyskinesia asynergy indicates a more severe disease of the coronary bed and myocardium.
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PMID:[Cardiac contractility in males with post-infarction cardiac sclerosis as evidenced by ultrasonic scanning]. 180 64

The activity of human myocardial enzymes in sudden coronary death (SCD) was quantitatively histochemically examined. The activity of succinate dehydrogenase (SDH), lactate dehydrogenase (LDH), beta-oxybutyrate dehydrogenase (beta-OBDH), alpha-glycerolphosphate dehydrogenase (alpha-GPDH), NAD-diaphorase (NAD-ase), and glucose-6-phosphate dehydrogenase (G-6-PDH) was measured on prompt autopsies (up to 3 hours of death onset). beta-OBDH and LDH showed an increase in activity in the myocardium from the subjects who had suddenly died from coronary heart disease without evident changes in the heart. In SCD in the presence of small cardiosclerosis, the activity of the enzymes characterizing the major processes of energy generation was also enhanced, which was caused by moderately severe myocardial hypertrophy. In the myocardium from the subjects who had died from coronary heart disease in the presence of large postinfarction cardiosclerosis, the activity of the enzymes was directly related to the degree of myocardial hypertrophy and the signs of chronic heart failure. As myocardial hypertrophy progressed, the enzymatic activity rose, but there were signs of chronic heart failure, it fell. The findings suggest that the changes in myocardial enzymatic activity in SCD are heterogeneous and associated with the type of prior abnormalities in the cardiovascular system.
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PMID:[Disorders of myocardial metabolism in sudden coronary death in the presence of coronary atherosclerosis: findings of quantitative histoenzymologic studies]. 221 37

Central hemodynamic parameters under the effect of mildronate were examined in 62 patients suffering from coronary heart disease, 35 of these with acute myocardial infarction complicated by acute left-ventricular insufficiency and 20 with atherosclerotic cardiosclerosis with chronic cardiac insufficiency. The drug effect was assessed in two groups of patients after a single intravenous injection of 0.5-3 g. In group 1 (n = 53) mildronate effect on central hemodynamic parameters was assessed in spontaneous cardiac rhythm. Variously directed statistically unreliable hemodynamic shifts were revealed, related to heart rhythm changes. In group 2 (n = 9) the drug effect on heart rhythm was eliminated with the use of two-chamber electrocardiostimulation, and various hemodynamic regimens with hypo-, eu-, and hyperkinetic circulation types were artificially created by changing the A-V interval. Mildronate had no effect on the hemodynamics during two-chamber electrocardiostimulation.
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PMID:[Effects of mildronate (quaterin) on hemodynamics in spontaneous and artificial heart rhythm in patients with ischemic heart disease]. 226 94


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