Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0018801 (heart failure)
 72,216 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Metabolic status of 650 patients operated on under artificial circulation for various cardiac diseases was studied. Circulatory hypoxia was found to underlie all metabolic disorders in artificial circulation which manifest by loss of buffer bases and lactate accumulation. Development of circulatory hypoxia in artificial circulation is caused by inadequate oxygen supply to tissues due to initially present disorders of the peripheral bloodstream which augment during perfusion by circulation centralization and due to changes of blood rheology, particularly so in increase of hypothermia and prolongation of perfusion. Lactate concentration during artificial circulation is an objective criterion of tissue hypoxia which sufficiently well correlates with development of heart failure in the early postperfusion period. When correcting circulatory hypoxia during artificial circulation the anesthesiologist and perfusiologist should aim at changing the vascular tone towards an increase of the peripheral bloodflow. This is particularly important during prolonged hypothermic perfusions in patients with initially low reserve potential of the myocardium.
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PMID:[Pathophysiological aspects of the development of circulatory hypoxia in artificial circulation]. 764 67

Clinical and hemodynamic efficacy of isolated ultrafiltration (IUF) has been assessed during treatment of congestive coronary failure in 11 patients. Forty IUF sessions have been performed. High therapeutic efficacy of the technique has been established. It has been shown that during IUF a decrease in volumic heart overload is accompanied by an increase in heart performance and O2 consumption. In terminal stages of heart failure IUF may lead to an imbalance between higher oxygen consumption and the capacity of cardiorespiratory system to deliver O2, which might cause the onset of circulatory hypoxia in the course of IUF.
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PMID:[The use of isolated ultrafiltration for the treatment of congestive circulatory failure]. 806

Intravenous colloid and crystalloid solutions are the mainstay of the acute bleeding therapy. Infusion therapy normalizes the blood circulation volume and improves its flow characteristics. The conducted study revealed that the method normovolemic hemodilution lead to an early unknown type of oxygen insufficiency called the dilutional anemic hypoxia. Authors set up and proved the hypothesis, that decompensated dilutional anemic hypoxia lead to cardiac insufficiency, leading finally to the so called dilutional circulatory hypoxia.
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PMID:[The infusion therapy of the acute bleeding]. 1883 53