Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0018801 (heart failure)
 72,216 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Prosthetic valve endocarditis (PVE) represents a rare and serious complication of valve replacement associated with high morbidity and mortality, which significantly differs from native valve endocarditis (NVE). There are two major problems: establishing diagnosis and treatment of PVE. Diagnosis in PVE is challenging and often requires several imaging methods besides standard microbiological analyzes. Transesophageal echocardiographic examination remains the widely used imaging technique in PVE diagnosis, but additional techniques such as computed tomography (CT) and 18F-fluodeoxyglucose positron emission tomography/CT are often necessary. Persistent fever, embolic complications, valve dehiscence, intracardial abscess, heart failure, as well as staphylococcal and fungal PVE require surgical treatment to avoid lethal outcome. The introduction of transcatheter valve implantations and devices significantly complicated the approach - diagnostic and therapeutic to PVE patients. Despite constantly increasing knowledge regarding pathogenesis and treatment of PVE, the optimal therapy remains a matter of debate. Additional studies are necessary to define therapeutic strategies for this potentially fatal complication.
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PMID:Prosthetic valve endocarditis - A trouble or a challenge? 3038 5

Prosthetic valve endocarditis (PVE) is a catastrophic complication of cardiac valve replacement, associated with high mortality rates. Staphylococci (both Staphylococcus aureus and coagulase-negative Staphylococcui) are the most common cause of PVE. Diagnosis may often be difficult because of its complications and extracardiac manifestations. Positive blood and valve cultures are one of the most important diagnostic criteria for IE. Transesophageal echography should be performed without delay in all patients suspected to have PVE. As for treatment, according to the guidelines sensitive antimicrobials should be administered for 6 weeks. Surgery is recommended in case of PVE complicated by heart failure, severe prosthetic dysfunction, abscess or persistent fever. We present a case of PVE after transurethral resection of the prostate in a 63-year-old male patient with a history of mitral valve replacement. The patient was treated by appropriate antimicrobials for 6 weeks and recovered completely.
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PMID:Enterococcal prosthetic valve endocarditis secondary to transurethral prostatic resection. 3205 42


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