Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0018801 (heart failure)
 72,216 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 48-year-old man, not diagnosed before, hardly physically working before admission, was admitted to cardiological ward at a regional hospital in bad condition, with severe heart failure symptoms. Massive calcification of the bicuspidal aortic valve was found during the echocardiography examination. Mean systolic aortic gradient was 32 mmHg. Left ventricular ejection fraction was reduced to 20%. The patient was treated with diuretics, digitalis, dobutamine and dopamine infusion but his condition was getting worse. On the 10th day of hospitalisation, he was transferred to cardio-surgical ward and aortic valve was replaced. On the 15th day following operation the patient came back to the regional hospital in good condition. The echocardiography examination revealed an increase in systolic ejection fraction of the left ventricle up to 48% in one month and to 55% in six months after surgery.
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PMID:[Significant aortic stenosis with a low pressure gradient and depressed left ventricular function. A case report]. 1698 Oct 58

A 74-year-old man, who had a history of a mitral valve replacement for rheumatic heart disease (RHD) 30 years previously, was admitted with progressive heart failure. Massive calcification was observed around the left atrium on multidetector CT, in addition to a late gadolinium enhancement (LGE)-positive layer adjacently outside of the calcification on MRI. He underwent a second mitral valve replacement for the prosthetic valve failure. Pathohistological analyses of a tissue section of the left atrial wall from a surgical specimen revealed lymphocyte and macrophage infiltration that coincided with the LGE-positive layer on MRI, suggesting the existence of sustained active inflammation even after the long period of RHD.
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PMID:Pathohistological Evidence of Smoldering Inflammation in Rheumatic Heart Disease with Massive Left Atrial Calcification. 2704 Nov 59